Protein Alignment Axs and ANO10

DIOPT Version :10

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001333393.1
• Gene: ANO10 / 55129
• HGNCID: 25519
• Length: 699
• Species: Homo sapiens
• Alignment Length: 707
• Identity: 229/707 - (32%)
• Similarity: 343/707 - (48%)
• Gaps: 132/707 - (18%)

  Fly    50 DTEPFDKTHIVIIFTEKAKLRHCQDVEKIIQEF------------GIQTTLE-IVGKTE------ 95
            ||.....|.:|:|  |.|     |||::..:|:            |.|.... ::.|.|
Human     9 DTSESSFTPLVVI--ELA-----QDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQETLEN 66

  Fly    96 KYLYL-SASVDTLLRLADAAELEKMTTTHSMQKFNHGCISDFLLPGMGKEQILRYCEIPVLIKDV 159
            :.||| .||...:|..|:|..|.|....::|:.|.:....:|.......:..|...|...:||..
Human    67 QNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLTMAECQFIIKHE 131

  Fly   160 IQD-------GIKSYVQ---------------KGYIEDMFPLHDILYLERF--NWNLKRTKL--- 197
            :::       .|..|.|               .|.:..:|||||...|::.  .| ..|..|
Human   132 LENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALKKLEDTW-YTRFALKYQ 195

  Fly   198 PIEDIRNYFGSSIGLYFGFIEFYTKALIFPSLFGILQYVF-----DLNISLVCSFYVVWTTIFLE 257
            ||:.||.|||.:|.|||||:|::|.|||..::.|:..|:|     |..: :..||.::|:|:.||
Human   196 PIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKYV-IFASFNLIWSTVILE 259

  Fly   258 LWKRKCAGYSYRWGTIEMS-SLDKPRSAYTGQLKPDPITGKMTLHYPMRYTYLQMYCISYPVVLG 321
            ||||.||..:|||||:.|. ..::||..:.|.|..:.||||....||.....|::|.:|.|.|..
Human   260 LWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLVSLPFVCL 324

  Fly   322 CVVAAGWFALYQFQI--EAEV----LADFGPDSW---LLYVPVIVQSVLIAIFSWAYEKLATFLT 377
            |:    :|:||...|  :.||    |.:.....|   |||||.|:.:::|.|.:..|...|.|||
Human   325 CL----YFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNRLYRYAAEFLT 385

  Fly   378 NLENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAFVLHDLRQLKYQLMMQLLVFQLLCIAQEIG 442
            :.||||..|.|..|.:.|:::|..:|.|.|.|||||||.|::.|:..|...|:..|:|....|..
Human   386 SWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKDMKLLRQSLATLLITSQILNQIMESF 450

  Fly   443 IPLLAVLRQKYAEFRHREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLF 507
            :|..  |::|:.....|:|  :.|::..|...|||...|..:..|..|::|||::.:|||:|.||
Human   451 LPYW--LQRKHGVRVKRKV--QALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLF 511

  Fly   508 AAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAW--------------------- 551
            :.|.|.||..|:|||...|:.|..|:|.:|||||:..:.|||.|
Human   512 SCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQIIFCLDTGVKRGLNCKVMRN 576

  Fly   552 ------------------QLAFELLSVMSLLSNCGLLFLQPNVKDFFSHWLPSVPDLSFVI--FE 596
                              |||||.:||:|:::||.|:.:.|.|...|..   |..||..::  .|
Human   577 LLGEMEMSCVLFVVVVVSQLAFETMSVISVVTNCALIGMSPQVNAVFPE---SKADLILIVVAVE 638

  Fly   597 HLLLGLKFLIHKVIHERPRWVRIGLLKADFETSQALKQ---------LKKFKAEANK 644
            |.||.|||::...|.::||.:::.|.:.:||:.:||||         ||:...|:.|
Human   639 HALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGK 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:461349	172/476 (36%)
ANO10	NP_001333393.1	Anoctamin	200..665	CDD:461349	172/476 (36%)