DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Axs and ANO1

DIOPT Version :9

Sequence 1:NP_476777.1 Gene:Axs / 32645 FlyBaseID:FBgn0000152 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_001365021.1 Gene:ANO1 / 55107 HGNCID:21625 Length:1049 Species:Homo sapiens


Alignment Length:879 Identity:188/879 - (21%)
Similarity:315/879 - (35%) Gaps:311/879 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SEDAKSPGPRTRNIIENQLFRRQR---SLKLEALQRQRTLDSNDGVEGLGADTEPFDKTH----I 59
            |.||.|..|......:::.|||:.   :|....|:.:|  |.:..:.|:|     |.|.|    :
Human   148 SLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELER--DEDTKIHGVG-----FVKIHAPWNV 205

  Fly    60 VIIFTEKAKLR-------HCQDVEKIIQEFGIQTTLEIV-----------------------GKT 94
            :....|..||:       |..:...::::  |.:.|:.:                       .:.
Human   206 LCREAEFLKLKMPTKKMYHINETRGLLKK--INSVLQKITDPIQPKVAEHRPQTMKRLSYPFSRE 268

  Fly    95 EKYLY-LS---ASVDTLLRLADAAELEKMTT-THSMQKFNHGCISDFLLPGMGKEQIL----RYC 150
            :::|: ||   :..|:..|.....|:.|.|| |.:......|       .|..|:..|    |.|
Human   269 KQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGQG-------EGRKKDSALLSKRRKC 326

  Fly   151 EIPVLIKDVIQDGIKSYVQKGYIEDMFPLHD--------------ILYLERFNWNLKRTKLPIED 201
            .         :.||.|.:..|.....:||||              :||.|...:.:.....||:.
Human   327 G---------KYGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDL 382

  Fly   202 IRNYFGSSIGLYFGFIEFYTKALIFPSLFGILQYVF-----DLNI-------------------- 241
            :|.|||..|||||.::..||:.||..|:.||:.:::     |.||                    
Human   383 VRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDK 447

  Fly   242 -------SLVCS------------------FYVVWTTIFLELWKRKCAGYSYRWGTI-----EMS 276
                   |..|:                  |..:|...|:|.||||....:|||...     |.:
Human   448 TCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEA 512

  Fly   277 SLDKPRSAYTGQ-----LKPD-----------------------------PITGKMTLHYPMRY- 306
            ..|.||:.|..:     ||.:                             .:|.|:.|.:..|: 
Human   513 VKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFP 577

  Fly   307 TYLQ-------MYCISYPVVLGCVVAAGWFALYQFQIEAEVLADFGPD------SWLLYVPVIVQ 358
            .||.       |..:::.:|||.::       |:..:.|.:..:..|.      ..:....||:.
Human   578 AYLTNLVSIIFMIAVTFAIVLGVII-------YRISMAAALAMNSSPSVRSNIRVTVTATAVIIN 635

  Fly   359 SVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAF---------- 413
            .|:|.:....|..:|.:||.:|..:|...::...:.|..|.:.||::...||:||          
Human   636 LVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPG 700

  Fly   414 ----VLHDLR-----------QLKYQLMMQLLVFQLLCIAQ----EIGIPLLAVLRQKYAEFR-- 457
                :....|           :|..||.:.:|..||:   |    |||||.:..| .:|.:.:  
Human   701 DYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLI---QNNLFEIGIPKMKKL-IRYLKLKQQ 761

  Fly   458 ----HREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLFAAVAPFAAIGA 518
                |.|..:.|       .|||..:   .|:.:.....:|:::.||||||.||.|..|.|.:.|
Human   762 SPPDHEECVKRK-------QRYEVDY---NLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFA 816

  Fly   519 LLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNC-----------GLLFL 572
            ||||:..:.:|..|.....:||.|.|||:||.|......:..::::.|.           .|::|
Human   817 LLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYL 881

  Fly   573 QP------------------NVKDFFSHWLPSVP-DLSF-------------------------- 592
            ..                  ||.||.:...|:.| ||.:                          
Human   882 YMYSKNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDF 946

  Fly   593 -----------VIFEHLLLGLKFLIHKVIHERPR 615
                       ::|::|::.:...:..||.:.|:
Human   947 WAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPK 980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AxsNP_476777.1 Anoctamin 202..623 CDD:282414 136/619 (22%)
ANO1NP_001365021.1 Anoct_dimer 95..380 CDD:406563 50/256 (20%)
Anoctamin 383..989 CDD:398306 136/619 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1263362at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

Return to query results.
Submit another query.