Protein Alignment Axs and ANO7

DIOPT Version :9

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_011509565.1
• Gene: ANO7 / 50636
• HGNCID: 31677
• Length: 940
• Species: Homo sapiens
• Alignment Length: 634
• Identity: 157/634 - (24%)
• Similarity: 253/634 - (39%)
• Gaps: 176/634 - (27%)

  Fly   163 GIKSYVQKGYIEDMFPLHD-------------------ILYLERFNWNLKRTKLPIEDIRNYFGS 208
            ||...:.:|.:...|||||                   :|:.....|.......|::.:|.|||.
Human   276 GIHQLLAEGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGE 340

  Fly   209 SIGLYFGFIEFYTKALIFPSLFGILQYV---------------------FDL-NISLVCSFYV-- 249
            .:.|||.::.|||..|:..::.|.|.::                     |:: .:.|.|.|::
Human   341 KVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGSKDSFEMCPLCLDCPFWLLS 405

  Fly   250 -------------------------VWTTIFLELWKRKCAGYSYRWGTIEMSSL-DKPR---SAY 285
                                     :|..:.||.||||.|..:|||...:.... ::||   :|.
Human   406 SACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEERPRPQFAAS 470

  Fly   286 TGQLKPDPITGKMTLHYPMRYTYLQMYC------ISYPVVLGCVVAAGWFALYQFQIEAEVLADF 344
            .....|:||||:...::|.|....:|..      :...||:.|:|:   ..||: .|.|.|::..
Human   471 APMTAPNPITGEDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVS---IILYR-AIMAIVVSRS 531

  Fly   345 GPD---SWLLYVP----VIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIV 402
            |..   :|...:.    .:|..|.|.|.|..|..||..||..|.|||:::::.....|:.:|:.|
Human   532 GNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFIFQFV 596

  Fly   403 NNFFSQFYIAFV----------LHDLRQLK----------YQLMMQLLVF----QLLCIAQEIGI 443
            |.:.|..||||.          .|.|..::          .:|..:|||.    |::...||:.|
Human   597 NFYSSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLI 661

  Fly   444 PLLAVLRQKYAEFRHREVAEEKLRSISDLPRYEQSFYESGLDEY-----HSTYEDYLQVCIQFGF 503
            |.|....||   ||.|    .|.|.........|..:|   |:|     ...:::||::.:||||
Human   662 PKLKGWWQK---FRLR----SKKRKAGASAGASQGPWE---DDYELVPCEGLFDEYLEMVLQFGF 716

  Fly   504 VVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCG 568
            |.:|.|..|.|.:.|||||...:.:|..|....::||.|.||::||.|......|:.::::||..
Human   717 VTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAF 781

  Fly   569 LL-----FL---------QPNVKDFFSHWLPSVPD------------------------------ 589
            ||     ||         ..:::.|.:..|...|.
Human   782 LLAFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYSQTYWNLL 846

  Fly   590 ---LSFVI-FEHLLLGLKFLIHKVIHERPRWVRIGLLKADFETSQALKQ 634
               |:||| |||::..:..|:..::.:.|..|.|.:.:..:...|||.:
Human   847 AIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAE 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	143/563 (25%)
ANO7	XP_011509565.1	Anoct_dimer	106..331	CDD:292796	10/54 (19%)
		Anoctamin	334..885	CDD:282414	143/564 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920