DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axs and ANO9

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001012302.2	Gene:	ANO9 / 338440	HGNCID:	20679	Length:	782	Species:	Homo sapiens

Alignment Length:	663	Identity:	129/663 - (19%)
Similarity:	243/663 - (36%)	Gaps:	252/663 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 KDVIQDGIKSYVQKGYIEDMFPLHDILYLERFNWNLKRT---------KLPIEDIRNYFGSSIGL 212
            :|:::||:        .|..||||      :....||:|         :.|:::||||||..:.|
Human   139 EDLMKDGV--------FEARFPLH------KGEGRLKKTWARWRHMFREQPVDEIRNYFGEKVAL 189

  Fly   213 YFGFIEFYTKALIFPSLFGILQYV--FDL-----------------------------NISLVCS 246
            ||.::.:||..|:..:|.|:|.::  |.|                             .:|..|:
Human   190 YFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDILMCPLGDHSRRYQRLSETCT 254

  Fly   247 ------------------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLDKPRSAYTGQL--KP 291
                              |..:|.|:|||:|||:.|.....|   ::...|:.:.....||  .|
Human   255 FAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHW---DLYVWDEEQEEMALQLINCP 316

  Fly   292 DPITGKMTLHY---PMRYTYLQ----------MYCI----SYPVVLGCVVAAGWFA-----LYQF 334
            |         |   |.:::||:          |.|:    ::.:|:..|:|:..|:     ..:.
Human   317 D---------YKLRPYQHSYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASALFSSSAVPFLEE 372

  Fly   335 QIEAEVLADFGPDSWLLYVPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLF 399
            |:...|:.          ...:|..|.|.|.:.....:|..|.:.|..||.|:.:.....:....
Human   373 QVTTAVVV----------TGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTL 427

  Fly   400 EIVNNFFSQFYIAFVL-----HDLRQLK----------------YQLMMQLLVF----QLLCIAQ 439
            :...:|.|..||||:|     |..:..:                ..|.:|:.:.    |.|....
Human   428 QFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCV 492

  Fly   440 EIGIPLLAVLRQKYAEFRHREVAEEKLRSI-----SDLPR------YEQSFYESGLDEYHSTYED 493
            |..:|.:.                .|.||:     ..|||      :.:::..:.::.: |.:::
Human   493 EYLVPWVT----------------HKCRSLRASESGHLPRDPELRDWRRNYLLNPVNTF-SLFDE 540

  Fly   494 YLQVCIQFGFVVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELL 558
            ::::.||:||..:|.|..|.|.:.||.:|:..:.:|..|:..:.:|...|:||:||.|....|.:
Human   541 FMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETI 605

  Fly   559 SVMSLLSNCGLLFLQPNVKDFFSHWLPSV------------------------------------ 587
            .|:::::| |::..      |.|.::|.|
Human   606 GVLAVIAN-GMVIA------FTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDF 663

  Fly   588 -----------------------PDLSF---------------VIFEHLLLGLKFLIHKVIHERP 614
                                   ||.:|               ::|||:.|.:|.:....:.:.|
Human   664 QDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIP 728

  Fly   615 RWVRIGLLKADFE 627
            :.|:..:|:..::
Human   729 QSVKNKVLEVKYQ 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	116/603 (19%)
ANO9	NP_001012302.2	Anoct_dimer	<115..176	CDD:292796	11/50 (22%)
		Anoctamin	179..735	CDD:282414	116/601 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	756..782
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920