Protein Alignment Axs and Ano4

DIOPT Version :10

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_006513818.1
• Gene: Ano4 / 320091
• MGIID: 2443344
• Length: 1154
• Species: Mus musculus
• Alignment Length: 868
• Identity: 187/868 - (21%)
• Similarity: 330/868 - (38%)
• Gaps: 277/868 - (31%)

  Fly     6 KSPGPRTRNIIENQLFRRQRSLKLEALQ--RQRTLDSNDGV--------EGLGADTE------PF 54
            :...|:|.   :.::|  :|:::.|.||  ::.:|.::|.:        |.||...|      ||
Mouse   325 RKSNPQTE---KREVF--ERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMNVRMPF 384

  Fly    55 DKTHIVIIFTEKAKLRHCQDVEKIIQEFGIQTTLEIVGKTEKYL---YLSASVDTLLRLADAAEL 116
            .:.    |:....:.:....::|.|..|            .::|   .:....:|   |.|..|.
Mouse   385 RRK----IYYLPRRYKFMSRIDKQISRF------------RRWLPKKPMRLDKET---LPDLEEN 430

  Fly   117 EKMTTTHSMQKFNHGCISDFLLPGMGKEQILRYCEIPVLIKDVIQD----------GIKSYVQKG 171
            :..|...|.|:.:|..|.:       |:..........::..::|.          |:...:..|
Mouse   431 DCYTAPFSQQRIHHFIIHN-------KDTFFNNATRSRIVHHILQRIKYEEGKNKIGLNRLLTNG 488

  Fly   172 YIEDMFPLHD-------------------ILYLERFNWNLKRTKLPIEDIRNYFGSSIGLYFGFI 217
            ..|..||||:                   :||....:|.:.....|::.:|.|||..|||||.::
Mouse   489 SYEAAFPLHEGSYRSKNSIKTHGAVNHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWL 553

  Fly   218 EFYTKALIFPSLF-GILQYVF------------------DLNISLVCS----------------- 246
            .:|| .::||:.| |:..:::                  |:.:..||.
Mouse   554 GWYT-GMLFPAAFIGLFVFLYGVTTLDHCQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKV 617

  Fly   247 --------------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLD---KPR--SAYTGQLKPD 292
                          |..||.|:|||.|||:.|..:|.|..|:....:   :|:  :.|:.:.:.:
Mouse   618 THLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMN 682

  Fly   293 PITGKMTLHYPMRYTYLQMYCISYPV------VLGCVVAAGWFALYQFQIEAEVLADFGPDSWLL 351
            ||:||     |..|......|....|      .:.|||.|..|.:..:::  ..::.|....|.|
Mouse   683 PISGK-----PEPYQAFTDKCSRLIVSASGIFFMICVVIAAVFGIVIYRV--VTVSTFAAFKWAL 740

  Fly   352 Y----------VPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNFF 406
            .          ..|.:...:|.:.:..|||:|..|||||..||.|:::.....|:.||:.||...
Mouse   741 IRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNS 805

  Fly   407 SQFYIAFVL-----HDLRQLK----------------YQLMMQLLVFQLLCIA----QEIGIPLL 446
            |.|||||.|     |....|:                ..|.||:.:..:|...    .|:|.||:
Mouse   806 STFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLI 870

  Fly   447 AVLRQKY---AEFRHREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLFA 508
                |.:   .:.|.....|.|:    :.|::|:.:....::.| ..:::||::.:||||..:|.
Mouse   871 ----QNWWTRRKVRQEHGTERKI----NFPQWEKDYNLQPMNAY-GLFDEYLEMILQFGFTTIFV 926

  Fly   509 AVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLLFLQ 573
            |..|.|.:.|||||:..:.:|.:|....::||.|.|||:||.|....|.:.::|:::|..::.:.
Mouse   927 AAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAIT 991

  Fly   574 PN-------------------------------------VKDF------------FS-------- 581
            .:                                     :.||            ||
Mouse   992 SDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCR 1056

  Fly   582 -------------------HWLPSVPDLSFVI-FEHLLLGLKFLIHKVIHERPRWVRIGLLKADF 626
                               .|......|:|:| ||||:..:|.||..:|.:.|:.:|..:.:..:
Mouse  1057 YRDYRDPPHSLAPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKY 1121

  Fly   627 ETSQ-----ALKQLKKFKAEANK 644
            ...:     .|::|:|.:.|..|
Mouse  1122 LIQEMMYEAELERLQKERKERKK 1144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:461349	140/596 (23%)
Ano4	XP_006513818.1	Anoct_dimer	310..535	CDD:465044	41/240 (17%)
		Anoctamin	538..1119	CDD:461349	140/597 (23%)