Protein Alignment Axs and Ano6

DIOPT Version :10

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_008763957.1
• Gene: Ano6 / 315272
• RGDID: 1304765
• Length: 932
• Species: Rattus norvegicus
• Alignment Length: 730
• Identity: 177/730 - (24%)
• Similarity: 291/730 - (39%)
• Gaps: 188/730 - (25%)

  Fly     3 EDAKSPGPRTRNIIENQLFRRQ---RSLKLEALQRQRTLDSNDGVEGLGADTEPFDKTH----IV 60
            ||........:...|.|..:||   .:|....||.:.|...:|       |...|.|.|    ::
  Rat    99 EDESKKENNKKGTNEKQKRKRQAYESNLISHGLQLEATRSVSD-------DKLVFVKVHAPWEVL 156

  Fly    61 IIFTE----KAKLRHCQDVEKIIQEFGIQTTLEIVGKTEKYLYLSASVDTLLRLADAAELEKMTT 121
            ..:.|    |..|:.        .:...::|.:......|.|.::.||       ...|.|..|.
  Rat   157 CTYAEIMHIKLPLKP--------NDLKTRSTFDTFNWFTKVLRVNESV-------IKPEQEFFTA 206

  Fly   122 THSMQKFNHGCISD---FLLPGMGKEQILRYCEIPV---LIKDVIQDGIKSYVQKGYIEDMFPLH 180
            .....:.|...|.|   |..|.. :.:|:.:....|   ::.:|.:.||...|..|..:..||||
  Rat   207 PFEKSRMNDFYILDRDSFFNPAT-RSRIVYFILSRVKYQVMNNVNKFGINRLVSSGIYKAAFPLH 270

  Fly   181 D-----------------ILYLERFNWNLKRT---KLPIEDIRNYFGSSIGLYFGFIEFYTKALI 225
            |                 :||.|   |...|:   |.|::.||.|:|..||:||.::.:||:.|:
  Rat   271 DCKFNYKSEDPNCPSERYLLYRE---WAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLL 332

  Fly   226 FPSLFGILQYVFD------------------------------------LNISLVCS-------- 246
            ..::.|:..:::.                                    |||:...|
  Rat   333 LAAVVGVACFLYGYLNQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFWRLNITCESSKKLCIFDS 397

  Fly   247 --------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLDKPRSAYTGQLK------------- 290
                    |..||.|:|||.|||:.|...|.|.|:|:...::||..|..|..
  Rat   398 FGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQPRPEYEAQCNHVVINEITQEEER 462

  Fly   291 -PDPITGK---MTLHYPMRYTYLQMYCISYPVVLGCVVAAGWFALYQFQIEAEVLA--DFGPDSW 349
             |....||   :||.....:.::.:...|   |:|.:|    :.|..|.:.:..|.  ..|.|..
  Rat   463 IPFTTCGKCIRITLCASAVFFWILLIIAS---VIGIIV----YRLSVFIVFSTTLPKNPNGTDPI 520

  Fly   350 LLYV---------PVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNF 405
            ..|:         ..|:..::|.|.:..|||:|..:||.|..||::.|:.....|:.||:.||.:
  Rat   521 QKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYY 585

  Fly   406 FSQFYIAFV-----------LHDLRQLKYQ------LMMQLLVFQLLCI---------AQEIGIP 444
            .|.|||||.           ::.|.:.:.:      .:::|.. ||..|         .||:.:|
  Rat   586 SSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTT-QLTIIMGGKAIWNNIQEVLLP 649

  Fly   445 LLAVLRQKYAEFRHREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLFAA 509
            .:..|..:|    .|....||:     .||:||.::...:......|| ||::.||||||.||.|
  Rat   650 WVMNLIGRY----KRVSGSEKI-----TPRWEQDYHLQPMGRLGLFYE-YLEMIIQFGFVTLFVA 704

  Fly   510 VAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLL-FLQ 573
            ..|.|.:.||:||:..:.:|.|||...|:|....:|::|||||...:.::::::::|..:: |..
  Rat   705 SFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTS 769

  Fly   574 PNVKDFFSHWLPSVP 588
            ..:.....:|..|:|
  Rat   770 DMIPRLVYYWSFSIP 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:461349	127/494 (26%)
Ano6	XP_008763957.1	Anoct_dimer	84..306	CDD:465044	49/232 (21%)
		Anoctamin	309..892	CDD:461349	127/494 (26%)