DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axs and Ano3

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_038962388.1	Gene:	Ano3 / 311287	RGDID:	1308873	Length:	981	Species:	Rattus norvegicus

Alignment Length:	836	Identity:	185/836 - (22%)
Similarity:	317/836 - (37%)	Gaps:	248/836 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IENQLFRRQRSLKLEALQRQRTLDSNDGVEGLGADTEP--------FDKTHI----VIIFTEKAK 68
            |:..|..|:.:::.:   ::.|.:.|...|||..:.||        |.|.||    :..:.|:..
  Rat   164 IDYILVYRKTNIQYD---KRNTFEKNLRAEGLMLEKEPAVANPDIMFIKVHIPWDTLCKYAERLN 225

  Fly    69 LR-----HCQDVEKIIQEFGIQTTLEIVGKTEKYL-----YLSASVDTLLRLA--DAAELEKMTT 121
            :|     .|...::         ..:.:.:.:||.     ::|.:...|.:.|  :..|.:..|.
  Rat   226 IRVPFRKKCYYTDQ---------KNKSMSRVQKYFKRIKKWMSQNPMVLDKSAFPELEESDCYTG 281

  Fly   122 THSMQKFNHGCIS--DFLLPGMGKEQILRY-CEIPVLIKDVIQDGIKSYVQKGYIEDMFPLHD-- 181
            ..|..:.:|..|:  |.......:.:|:.: .|.......:.:.||:..:..|.....||.|:
  Rat   282 PFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGA 346

  Fly   182 -----------------ILYLERFNWNLKRTKLPIEDIRNYFGSSIGLYFGFIEFYTKALIFPSL 229
                             :||.....|.:.....|::.||.|||..|||||.::.:||..||..::
  Rat   347 YKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAV 411

  Fly   230 FGILQYVFDL---NISLV-------------------CS-------------------------- 246
            .|:..:.:.|   |.|.|                   ||
  Rat   412 VGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFA 476

  Fly   247 -FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLDKPRSAYTGQLKP------------DPITGKM 298
             |..:|.|:|||.|||:.:..:|.|..||....::       .|:|            :|||||.
  Rat   477 IFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEE-------TLRPQFEAKYYRMEIINPITGKP 534

  Fly   299 TLHYPM--RYTYLQMYCISYPVVLGCVVAAGWFALYQFQIEAEVLADFGPDSWLLY--------- 352
            ..|.|.  :.|.|.:.......::..|:.| .||:..:::  .|:..|....|...
  Rat   535 EPHQPSSDKVTRLLVSVSGIFFMISLVITA-VFAVVVYRL--VVMEQFASFKWNFIKQHWQFATS 596

  Fly   353 -VPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAFVLH 416
             ..|.:..::|.:.:.||||:|..|||||..||.|:::.....|:.||:.||...|.|||||.|.
  Rat   597 GAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLG 661

  Fly   417 DL--RQLKYQ---------------------LMMQLLVF--QLLCIAQEIGIPLLAVLRQKYAEF 456
            ..  ...||.                     |.|.:::|  |:.....|:|.||:    |.:..
  Rat   662 RFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLI----QNWWS- 721

  Fly   457 RHREVAEEKLRSISD--LPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLFAAVAPFAAIGAL 519
            ||:     ..|.|.|  :|::|..:....:: .|...::||::.:||||..:|.|..|.|.:.||
  Rat   722 RHK-----IKRGIQDASIPQWENDWNLQPMN-IHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLAL 780

  Fly   520 LNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLLFLQP---------- 574
            |||:..:.:|.:|....::||...||.:||.|....|.:.::::::|..::.:..
  Rat   781 LNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEY 845

  Fly   575 ---------------------NVKDFF--------------------------------SHWLPS 586
                                 |...||                                .:|...
  Rat   846 KYGPCANHVKQNENCLKGYVNNSLSFFDLSELGIGKSGYCRYRDYRGPPWSSKPYEFTLQYWHIL 910

  Fly   587 VPDLSFVI-FEHLLLGLKFLIHKVIHERPRWVRIGLLKADFETSQALKQLKKFKAE 641
            ...|:|:| ||||:.|:|..|..:|.:.|:.:|..:.:..:     |.|...::||
  Rat   911 AARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKY-----LVQEMMYEAE 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	141/584 (24%)
Ano3	XP_038962388.1	Anoct_dimer	157..381	CDD:406563	39/228 (17%)
Ano3	XP_038962388.1	Anoctamin	384..949	CDD:398306	141/585 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920