DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axs and Ano5

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_006229328.1	Gene:	Ano5 / 308637	RGDID:	1564265	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	895	Identity:	195/895 - (21%)
Similarity:	333/895 - (37%)	Gaps:	304/895 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EDAKSPGPRTRNIIENQLFRRQRSLKLEALQRQRTLDSNDGV---EGLGADTEPFDKTHIVIIFT 64
            ||:: |.|..|    ..||.|:|      |..||:..|.|.|   :|:       .:...|:.:.
  Rat   380 EDSQ-PLPEKR----FNLFLRRR------LMFQRSEQSKDSVFFRDGI-------RQIDFVLSYV 426

  Fly    65 E--------KAKLRHCQDVEKIIQEFGIQTTLEIV-----GKTEKYLYLSASVDTLLRLADAAEL 116
            |        ||:.|  |..|:.:::.|::..:|..     ||| .::.:.|..:.|:..|:...:
  Rat   427 EDVKKDGELKAERR--QTFEQNLRKTGLELEIEDKMNSEDGKT-YFVKIHAPWEVLVTYAEVLGI 488

  Fly   117 EKMTTTHSMQKFNHGCISDFLLP---GMGKE---------QILRYCEIPVLIKDVI--------- 160
            :.......:.:..:..:|..|.|   .:|.:         |..|:.:...||:|..
  Rat   489 KMPIKLSDIPRPKYSPLSYMLGPVKLPLGVKYPKPEYFTAQFSRHRQELFLIEDEATFFPSSTRN 553

  Fly   161 -------------------QDGIKSYVQKGYIEDMFPLHDILYL---------ERF----NW--- 190
                               :.||:..:........:||||..|.         ||:    ||
  Rat   554 RIVYYILSRCPFGEEEGKKKIGIERLLNTNTYLSAYPLHDGQYWRPSKTSRINERYVLCKNWARF 618

  Fly   191 NLKRTKLPIEDIRNYFGSSIGLYFGFIEFYTKALIFPSLFGILQYVF---------------DLN 240
            :....:.|.:.||||:|..||:||.|:.:||:.|:|.:|.|:..:::               |.|
  Rat   619 SYFYKEQPFDLIRNYYGEKIGIYFVFLGYYTEMLLFAALVGLACFIYGLLSMESNQTSIEICDPN 683

  Fly   241 IS---LVCS----------------------------------FYVVWTTIFLELWKRKCAGYSY 268
            |.   ::|.                                  |..:|.|:|||.||::.|...|
  Rat   684 IGGQMIMCPLCDEVCDYWRLNTTCLHSKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEY 748

  Fly   269 RWGTIEMSSLDKPRSAYTGQLKPD-----------PITGKMTLHYPMRYTYLQMYCISYPVVLGC 322
            .|..::.....:..     ||:|:           |:|.:|..|.|:      .:.|.:..|.|.
  Rat   749 EWDLVDFEEEQQQL-----QLRPEFEAMCKHKKMNPVTQEMEPHMPL------CHRIPWYFVSGT 802

  Fly   323 VVAAGW-----------------FALYQFQIEAE-----VLADFGPDSWLLYVPVIVQSVLIAIF 365
            .|..|.                 ||::...:|:|     |...|.|..........:..::|.|.
  Rat   803 TVTFGMALLLSSMVSIIVYRLSVFAIFASFMESEATLQSVKRFFTPQLATALSASCLNCLVILIL 867

  Fly   366 SWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAFVLHD------------- 417
            ::.|||::.::|.:|..||..:|:.....|:.||:.||.:.|.||:||....
  Rat   868 NFFYEKISAWITKMEIPRTHQEYESSLTLKMFLFQFVNYYSSCFYVAFFKGKFVGYPGRYTYMFN 932

  Fly   418 ------------LRQLKYQLMMQLLVFQLLCIAQEIGIPLLAVLRQKYAEFRHREVA--EEKLRS 468
                        |.:|..||.:.::..|:.....|...||:      :..:|.|...  .|||.|
  Rat   933 LWRSEECGPPGCLIELTTQLTIIMIGKQIFGNIHEACQPLI------FNWWRRRRTRTHSEKLYS 991

  Fly   469 ISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLFAAVAPFAAIGALLNNVFAVHIDMWKL 533
                 |:||. ::..:..:...:.:||:..:|||||.||.|..|.|.:.||:||:..:.:|.|||
  Rat   992 -----RWEQD-HDLQVYGHRGLFYEYLETVMQFGFVTLFVASFPLAPLFALMNNIMGIRVDAWKL 1050

  Fly   534 CNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGL----------------------------- 569
            ...::||.|.:|.:||.||.....::::|:.:|..:
  Rat  1051 TTQYRRPVAAKAHSIGVWQDILYGMAILSVATNAFIVSFTSDIIPRLVYFYAYSKNSTEPLSGYI 1115

  Fly   570 -----LFLQPNVKDFFSHWLPS---------------VPD------------------LSFVI-F 595
                 :||   :.||.:|.:|.               .||                  ::|:| .
  Rat  1116 NNSLSVFL---IADFPNHTVPMEKKDFVTCRYRDYRYPPDHKGKYGHNMQFWHVLAAKMTFIIVM 1177

  Fly   596 EHLLLGLKFLIHKVIHERPRWVRIGLLKADFETSQALKQLKKFKAEANKM 645
            ||::...|||:..:|.:.|:.|   ..|...|....:|.:..|  |.||:
  Rat  1178 EHIVFLFKFLLAWMIPDVPKDV---AEKIKREKLMTVKIIHDF--ELNKL 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	136/600 (23%)
Ano5	XP_006229328.1	MIP-T3	30..>371	CDD:287245
		Anoct_dimer	411..626	CDD:292796	36/224 (16%)
		Anoctamin	630..1207	CDD:282414	137/605 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920