DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axs and Ano4

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_017450215.2	Gene:	Ano4 / 299714	RGDID:	1310252	Length:	1154	Species:	Rattus norvegicus

Alignment Length:	868	Identity:	187/868 - (21%)
Similarity:	331/868 - (38%)	Gaps:	277/868 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KSPGPRTRNIIENQLFRRQRSLKLEALQ--RQRTLDSNDGV--------EGLGADTE------PF 54
            :...|:|.   :.::|  :|:::.|.||  ::.:|.::|.:        |.||...|      ||
  Rat   325 RKSNPQTE---KREVF--ERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMNVRMPF 384

  Fly    55 DKTHIVIIFTEKAKLRHCQDVEKIIQEFGIQTTLEIVGKTEKYL---YLSASVDTLLRLADAAEL 116
            .:.    |:....:.:....::|.|..|            .::|   .:....:|   |.|..|.
  Rat   385 RRK----IYYLPRRYKFMSRIDKQISRF------------RRWLPKKPMRLDKET---LPDLEEN 430

  Fly   117 EKMTTTHSMQKFNHGCISDFLLPGMGKEQILRYCEIPVLIKDVIQD----------GIKSYVQKG 171
            :..|...|.|:.:|..|.:       |:..........::..::|.          |:...:..|
  Rat   431 DCYTAPFSQQRIHHFIIHN-------KDTFFNNATRSRIVHHILQRIKYEEGKNKIGLNRLLTNG 488

  Fly   172 YIEDMFPLHD-------------------ILYLERFNWNLKRTKLPIEDIRNYFGSSIGLYFGFI 217
            ..|..||||:                   :||....:|::.....|::.:|.|||..|||||.::
  Rat   489 SYEAAFPLHEGSYRSKNSIKTHGAVNHRHLLYECWASWSVWYKYQPLDLVRRYFGEKIGLYFAWL 553

  Fly   218 EFYTKALIFPSLF-GILQYVF------------------DLNISLVCS----------------- 246
            .:|| .::||:.| |:..:::                  |:.:..||.
  Rat   554 GWYT-GMLFPAAFIGLFVFLYGVTTLDHCQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKV 617

  Fly   247 --------------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLD---KPR--SAYTGQLKPD 292
                          |..||.|:|||.|||:.|..:|.|..|:....:   :|:  :.|:.:.:.:
  Rat   618 THLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMN 682

  Fly   293 PITGKMTLHYPMRYTYLQMYCISYPV------VLGCVVAAGWFALYQFQIEAEVLADFGPDSWLL 351
            ||:||     |..|......|....|      .:.|||.|..|.:..:::  ..::.|....|.|
  Rat   683 PISGK-----PEPYQAFTDKCSRLIVSASGIFFMICVVIAAVFGIVIYRV--VTVSTFAAFKWAL 740

  Fly   352 Y----------VPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNFF 406
            .          ..|.:...:|.:.:..|||:|..|||||..||.|:::.....|:.||:.||...
  Rat   741 IRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNS 805

  Fly   407 SQFYIAFVL-----HDLRQLK----------------YQLMMQLLVFQLLCIA----QEIGIPLL 446
            |.|||||.|     |....|:                ..|.||:.:..:|...    .|:|.||:
  Rat   806 STFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLI 870

  Fly   447 AVLRQKY---AEFRHREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLFA 508
                |.:   .:.|.....|.|:    :.|::|:.:....::.| ..:::||::.:||||..:|.
  Rat   871 ----QNWWTRRKVRQEHGTERKI----NFPQWEKDYNLQPMNAY-GLFDEYLEMILQFGFTTIFV 926

  Fly   509 AVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLLFLQ 573
            |..|.|.:.|||||:..:.:|.:|....::||.|.|||:||.|....|.:.::|:::|..::.:.
  Rat   927 AAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAIT 991

  Fly   574 PN-------------------------------------VKDF------------FS-------- 581
            .:                                     :.||            ||
  Rat   992 SDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCR 1056

  Fly   582 -------------------HWLPSVPDLSFVI-FEHLLLGLKFLIHKVIHERPRWVRIGLLKADF 626
                               .|......|:|:| ||||:..:|.||..:|.:.|:.:|..:.:..:
  Rat  1057 YRDYRDPPHSLAPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKY 1121

  Fly   627 ETSQ-----ALKQLKKFKAEANK 644
            ...:     .|::|:|.:.|..|
  Rat  1122 LIQEMMYEAELERLQKERKERKK 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	140/596 (23%)
Ano4	XP_017450215.2	Anoct_dimer	310..535	CDD:406563	41/240 (17%)
Ano4	XP_017450215.2	Anoctamin	538..1119	CDD:398306	140/597 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920