DRSC/TRiP Functional Genomics Resources

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Protein Alignment Axs and Ano2

DIOPT Version :10

Sequence 1:NP_476777.1 Gene:Axs / 32645 FlyBaseID:FBgn0000152 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_705817.2 Gene:Ano2 / 243634 MGIID:2387214 Length:1002 Species:Mus musculus


Alignment Length:680 Identity:155/680 - (22%)
Similarity:240/680 - (35%) Gaps:237/680 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 GIKSYVQKGYIEDMFPLHD--------------ILYLERFNWNLKRTKLPIEDIRNYFGSSIGLY 213
            ||.|.:.....|..:||||              :||.|...:.:.....||:.||.|||..||||
Mouse   298 GINSLIANNIYEAAYPLHDGEYDSPGDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLY 362

  Fly   214 FGFIEFYTKALIFPSLFGILQYVF-------DL-------------------------NISLVCS 246
            |.::..||..||..|:.|::.:::       |:                         |:|..|.
Mouse   363 FAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSKEMCDHQNAFTMCPLCDKSCDYWNLSSACG 427

  Fly   247 ------------------FYVVWTTIFLELWKRKCAGYSYRWGTI-----EMSSLDKPRSAYTGQ 288
                              |..:|.|:|||.|||......|.|...     |..|.:..|..|..:
Mouse   428 TARASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERSQEHSRPEYETK 492

  Fly   289 LKPDPI--TGKMTLH-------------------------YPMRY-TYLQMYCISYPVVLGCVVA 325
            ::...:  :||..:.                         |.|.: :.|.|..:::.:|.|.:| 
Mouse   493 VREKLLKESGKSAVQKLEANSPEDDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIV- 556

  Fly   326 AGWFALYQFQIEAEVLADFGPDS----WLLYVPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRS 386
                  |:....|.:..:....|    .:....||:..|:|.|....|..:|.:||.:|..:|..
Mouse   557 ------YRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQ 615

  Fly   387 QYDRHRVNKLMLFEIVNNFFSQFYIAF-------------VLHD------------LRQLKYQLM 426
            .::...:.|..|.:.||.:...||:||             .:.|            |.:|..||.
Mouse   616 TFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLS 680

  Fly   427 MQLLVFQLLCIAQ----EIGIPLLAVLRQKYAEFRHREVAEEKLRSISD---LPRYEQSFYESGL 484
            :.:|..||:   |    |||:|.|..|        .|::.:|.....||   ..|.||...:..|
Mouse   681 IIMLGKQLI---QNNIFEIGVPKLKKL--------FRKLKDETEPGESDPDHSKRPEQWDLDHSL 734

  Fly   485 DEYHSTYEDYLQVCIQFGFVVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIG 549
            :.|.....:|:::.||||||.||.|..|.|.:.||||||..|.:|..|.....:||.|.|.|:||
Mouse   735 EPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIG 799

  Fly   550 AWQLAFELLSVMSLLSNCGLLFLQPNVKDF---------FSH----------------------- 582
            .|   |::||.:...|.....|:.....||         :||                       
Mouse   800 IW---FDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEG 861

  Fly   583 ------------------------WLPSVPDLS-------------FVIFEHLLLGLKFLIHKVI 610
                                    |.|:..:.|             .:||::|::.|..|:..:|
Mouse   862 TQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSVLSARLAFVIIFQNLVMFLSVLVDWMI 926

  Fly   611 HERPRWVRIGLLKADFETSQALKQLKKFKA 640
            .:.|              :....|:||.|:
Mouse   927 PDIP--------------TDISDQIKKEKS 942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AxsNP_476777.1 Anoctamin 202..623 CDD:461349 138/608 (23%)
Ano2NP_705817.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..85
Anoct_dimer 91..348 CDD:465044 11/49 (22%)
Anoctamin 351..940 CDD:461349 140/623 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..523 2/21 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 958..1002
DLG4 binding (PDZ) 1000..1002
Blue background indicates that the domain is not in the aligned region.

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