DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axs and Ano5

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_006540885.4	Gene:	Ano5 / 233246	MGIID:	3576659	Length:	988	Species:	Mus musculus

Alignment Length:	874	Identity:	193/874 - (22%)
Similarity:	325/874 - (37%)	Gaps:	276/874 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EDAKSPGPRTRNIIENQLFR---RQ--------RSLKLEA---LQRQRTLDSNDGVEGLGADTEP 53
            ||.:||..|:.:..::..||   ||        ..||.:.   .:|:|..:.|....||..:||.
Mouse   131 EDLQSPFQRSEHSKDSVFFRDGIRQIDFVLSYVEDLKKDGELKAERRREFEQNLRKTGLDLETED 195

  Fly    54 ----------FDKTH----IVIIFTEKAKLRHCQDVEKIIQEFGIQTTLEIVG-KTEKYLYLSAS 103
                      |.|.|    :::.:.|               ..||:..:::.. ...||..||..
Mouse   196 KLNSEDGKTYFVKIHAPWEVLVTYAE---------------VLGIKMPIKLSDIPRPKYPPLSYM 245

  Fly   104 VDTLLRLADAAEL---EKMTTTHSMQKFNHGCISD--FLLPGMGKEQILRY--CEIPVLIKDVIQ 161
            :.. ::|..:.:.   |..|...|..:.....|.|  ...|...:.:|:.|  ...|..:::..:
Mouse   246 LGA-VKLPSSVKYPTPEYFTAQFSRHRQELFLIEDEATFFPSSTRNRIVYYILSRCPFGVEEGKK 309

  Fly   162 D-GIKSYVQKGYIEDMFPLHDILYL---------ERF----NW---NLKRTKLPIEDIRNYFGSS 209
            . ||:..:........:||||..|.         ||:    ||   :....:.|...||||||..
Mouse   310 KIGIERLLNSNTYLSAYPLHDGQYWKPSKTTRPNERYNLCKNWARFSYFYKEQPFHLIRNYFGEK 374

  Fly   210 IGLYFGFIEFYTKALIFPSLFGILQYVFDLNISL--------------------------VCS-- 246
            ||:||.|:.:||:.|:|.:|.|:..:::.| :|:                          ||.
Mouse   375 IGIYFVFLGYYTEMLLFAALVGLACFIYGL-LSMENNRTSTEICDPDIGGQMIMCPLCDEVCDYW 438

  Fly   247 -------------------------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLDKPRSAYT 286
                                     |..:|.|:|||.||::.|...|.|..::.....:..
Mouse   439 RLNTTCLHSKFSHLFDNESTVFFALFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQL---- 499

  Fly   287 GQLKPD-----------PITGKMTLHYPMRYTYLQMYCISYPVVLGCVVAAGW------------ 328
             ||:|:           |:|.:|..|.|:      .:.|.:..|.|..|..|.
Mouse   500 -QLRPEFEAMCKHKKMNPVTKEMEPHMPL------CHRIPWYFVSGTTVTFGMALLLSSMVSILI 557

  Fly   329 -----FALYQFQIEAE-----VLADFGPDSWLLYVPVIVQSVLIAIFSWAYEKLATFLTNLENHR 383
                 ||.:...:|:|     |.:.|.|..........:..::|.|.::.|||::.::|.:|..|
Mouse   558 YRLSVFATFASFMESEATLQSVKSFFTPQLATALSGSCLNCIVILILNFFYEKISAWITKMEIPR 622

  Fly   384 TRSQYDRHRVNKLMLFEIVNNFFSQFYIAFVLHD-------------------------LRQLKY 423
            |..:|:.....|:.||:.||.:.|.||:||....                         |.:|..
Mouse   623 THQEYESSLTLKMFLFQFVNYYSSCFYVAFFKGKFVGYPGSYTYMFNIWRSEECGPAGCLIELTT 687

  Fly   424 QLMMQLLVFQLLCIAQEIGIPLLAVLRQKYAEFRHREVA--EEKLRSISDLPRYEQSFYESGLDE 486
            ||.:.::..|:.....|...||:      :..:|.|...  .|||.|     |:||. ::..:..
Mouse   688 QLTIIMIGKQIFGNIHEAFQPLI------FNWWRRRRARTHSEKLYS-----RWEQD-HDLQVYG 740

  Fly   487 YHSTYEDYLQVCIQFGFVVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAW 551
            :...:.:||:..|||||..||.|..|.|.:.||:||:..:.:|.|||...::||.|.:|.:||.|
Mouse   741 HRGLFYEYLETVIQFGFATLFVASFPLAPLFALMNNIMGIRVDAWKLTTQYRRPVAAKAHSIGVW 805

  Fly   552 QLAFELLSVMSLLSNCGL----------------------------------LFL---------- 572
            |.....::::|:.:|..:                                  :||
Mouse   806 QDILFGMAIVSVATNAFIVSFTSDIIPRLVYFYAYSTNSTEPLSGYVNNSLSVFLIADFPNHTVP 870

  Fly   573 ----------------QPNVKDFFSH----WLPSVPDLSFVI-FEHLLLGLKFLIHKVIHERPRW 616
                            .|:.:|.:||    |......::|:| .||::...|||:..:|.:.|:.
Mouse   871 MEKKDFVTCRYRDYRYPPDHEDKYSHNMQFWHVLAAKMTFIIVMEHVVFLFKFLLAWLIPDVPKD 935

  Fly   617 VRIGLLKADFETSQALKQLKKFKAEANKM 645
            |   :.|...|....:|.:..|  |.||:
Mouse   936 V---VEKIKREKLMTIKIIHDF--ELNKL 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	136/598 (23%)
Ano5	XP_006540885.4	Anoct_dimer	148..363	CDD:406563	44/230 (19%)
Ano5	XP_006540885.4	Anoctamin	367..943	CDD:398306	137/602 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920