Protein Alignment Axs and ANO5

DIOPT Version :10

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_998764.1
• Gene: ANO5 / 203859
• HGNCID: 27337
• Length: 913
• Species: Homo sapiens
• Alignment Length: 922
• Identity: 203/922 - (22%)
• Similarity: 342/922 - (37%)
• Gaps: 321/922 - (34%)

  Fly     1 MSEDAKSPGPRTRNIIENQ---------LFRRQRSLKLEALQRQRTLDSNDGVEGLGADTEPFDK 56
            |||.:.|  .|..:.:.|:         ||.|:|.:..:..|.:.::...||:.          :
Human    27 MSEQSLS--SRETSFLINEETMPAKRFNLFLRRRLMFQKNQQSKDSIFFRDGIR----------Q 79

  Fly    57 THIVIIFTE--------KAKLRHCQDVEKIIQEFGIQTTLEIVGKTEK------YLYLSASVDTL 107
            ...|:.:.:        ||:.|  ::.|..:::.|::  |||..|.:.      ::.:.|..:.|
Human    80 IDFVLSYVDDVKKDAELKAERR--KEFETNLRKTGLE--LEIEDKRDSEDGRTYFVKIHAPWEVL 140

  Fly   108 LRLADAAELEKMTTTHSMQKFNHGCISDFL----LPGMGK--------EQILRYCEIPVLIKDV- 159
            :..|:...::.......:.:..|..||..|    ||...|        .|..|:.:...||:|.
Human   141 VTYAEVLGIKMPIKESDIPRPKHTPISYVLGPVRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQA 205

  Fly   160 ----------------------IQDGIKSY-----VQKGYIEDMFPLHDILYL----------ER 187
                                  |:||.|.:     :........:||||..|.          ||
Human   206 TFFPSSSRNRIVYYILSRCPFGIEDGKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNER 270

  Fly   188 F----NW---NLKRTKLPIEDIRNYFGSSIGLYFGFIEFYTKALIFPSLFGILQYVFDL-----N 240
            :    ||   :....:.|::.|:||:|..||:||.|:.|||:.|.|.::.|:..:::.|     |
Human   271 YTLHQNWARFSYFYKEQPLDLIKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHN 335

  Fly   241 IS--------------------LVCS---------------------------FYVVWTTIFLEL 258
            .|                    .||.                           |..:|.|:|||.
Human   336 TSSTEICDPEIGGQMIMCPLCDQVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEF 400

  Fly   259 WKRKCAGYSYRWGTIEMSSLDKPRSAYTGQLKPD-----------PITGKMTLHYPMRYTYLQMY 312
            ||::.|...|.|..::.....:..     ||:|:           .:|.:|..:.|: ||.:..|
Human   401 WKQRQARLEYEWDLVDFEEEQQQL-----QLRPEFEAMCKHRKLNAVTKEMEPYMPL-YTRIPWY 459

  Fly   313 CISYPVVLGCVVAAGWFAL----------YQFQIEAEVLADFGPDSWLLYV-----PVIVQS--- 359
            .:|     |..|.. |.:|          |:..:.|...:....|:.|..|     |.|..|
Human   460 FLS-----GATVTL-WMSLVVTSMVAVIVYRLSVFATFASFMESDASLKQVKSFLTPQITTSLTG 518

  Fly   360 -----VLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAF------ 413
                 ::|.|.::.|||::.::|.:|..||..:|:.....|:.||:.||.:.|.||:||
Human   519 SCLNFIVILILNFFYEKISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFV 583

  Fly   414 --------VLHDLR-----------QLKYQLMMQLLVFQLLCIAQEIGIPLLAVLRQKYAEFRHR 459
                    :.::.|           :|..||.:.:...|:....:|...||..    .:...|..
Human   584 GYPGKYTYLFNEWRSEECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLAL----NWWRRRKA 644

  Fly   460 EVAEEKLRSISDLPRYEQ-----SFYESGLDEYHSTYEDYLQVCIQFGFVVLFAAVAPFAAIGAL 519
            ....|||.|     |:||     ||...||      :.:||:...|||||.||.|..|.|.:.||
Human   645 RTNSEKLYS-----RWEQDHDLESFGPLGL------FYEYLETVTQFGFVTLFVASFPLAPLLAL 698

  Fly   520 LNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLLFL------------ 572
            :||:..:.:|.|||...::|..|.:|.:||.||.....::|:|:.:|..::..
Human   699 INNIVEIRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYY 763

  Fly   573 -------QPN------------VKDFFSHWLPS---------------VPD-------------- 589
                   ||.            :.||.:|..||               .||
Human   764 AYSTNATQPMTGYVNNSLSVFLIADFPNHTAPSEKRDFITCRYRDYRYPPDDENKYFHNMQFWHV 828

  Fly   590 ----LSFVI-FEHLLLGLKFLIHKVIHERPRWV-------RIGLLKA--DFETSQALKQL----- 635
                ::|:| .||::..:|||:..:|.:.|:.|       ::..:|.  |||.::..:.|
Human   829 LAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKILHDFELNKLKENLGINSN 893

  Fly   636 ---KKFKAEANK 644
               |....|.||
Human   894 EFAKHVMIEENK 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:461349	142/608 (23%)
ANO5	NP_998764.1	Anoct_dimer	72..289	CDD:465044	40/230 (17%)
		Anoctamin	292..868	CDD:461349	142/602 (24%)
		COG5594	<462..>583	CDD:227881	33/126 (26%)