DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axs and ANO6

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001191732.1	Gene:	ANO6 / 196527	HGNCID:	25240	Length:	931	Species:	Homo sapiens

Alignment Length:	734	Identity:	179/734 - (24%)
Similarity:	297/734 - (40%)	Gaps:	195/734 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EDAKSPGPRTRNIIENQLFRRQ--------RSLKLEALQRQRTLDSNDGVEGLGADTEPFDKTHI 59
            ||........:...|.|..:||        ..|:|||  .:..||          |...|.|.|.
Human    97 EDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEA--TRSVLD----------DKLVFVKVHA 149

  Fly    60 V-IIFTEKAKLRHCQ------DVEKIIQEFGIQTTLEIVGKTEKYLYLSASVD-TLLRLADAAEL 116
            . .:....|::.|.:      |::.....||   ||....|.       .||| ::::    .|.
Human   150 PWEVLCTYAEIMHIKLPLKPNDLKNRSSAFG---TLNWFTKV-------LSVDESIIK----PEQ 200

  Fly   117 EKMTTTHSMQKFNHGCISD---FLLPGMGKEQILRYCEIPV---LIKDVIQDGIKSYVQKGYIED 175
            |..|......:.|...|.|   |..|.. :.:|:.:....|   :|.:|.:.||...|..|..:.
Human   201 EFFTAPFEKNRMNDFYIVDRDAFFNPAT-RSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKA 264

  Fly   176 MFPLHD-----------------ILYLERFNWNLKRT---KLPIEDIRNYFGSSIGLYFGFIEFY 220
            .|||||                 :||.|   |...|:   |.|::.||.|:|..||:||.::.:|
Human   265 AFPLHDCKFRRQSEDPSCPNERYLLYRE---WAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYY 326

  Fly   221 TKALIFPSLFGILQYVF------------------------------------DLNISLVCS--- 246
            |:.|:..::.|:..:::                                    .|||:...|
Human   327 TQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKL 391

  Fly   247 -------------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLDKPRSAY------------T 286
                         |..||.|:|||.|||:.|...|.|.|:|:...::.|..|            |
Human   392 CIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEIT 456

  Fly   287 GQLKPDPITG-----KMTLHYPMRYTYLQMYCISYPVVLGCVV-AAGWFALYQFQIEAEVLADFG 345
            .:.:..|.|.     ::||.....:.::.:...|   |:|.:| ....|.::..::...:   .|
Human   457 QEEERIPFTAWGKCIRITLCASAVFFWILLIIAS---VIGIIVYRLSVFIVFSAKLPKNI---NG 515

  Fly   346 PDSWLLYV---------PVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEI 401
            .|....|:         ..|:..::|.|.:..|||:|..:||.|..||::.|:.....|:.||:.
Human   516 TDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQF 580

  Fly   402 VNNFFSQFYIAFV-----------LHDLRQLKYQ------LMMQLLVFQLLCI---------AQE 440
            ||.:.|.|||||.           ::.|.:.:.:      .:::|.. ||..|         .||
Human   581 VNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTT-QLTIIMGGKAIWNNIQE 644

  Fly   441 IGIPLLAVLRQKYAEFRHREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVV 505
            :.:|.:..|..::    ||....||:     .||:||.::...:.:....|| ||::.||||||.
Human   645 VLLPWIMNLIGRF----HRVSGSEKI-----TPRWEQDYHLQPMGKLGLFYE-YLEMIIQFGFVT 699

  Fly   506 LFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLL 570
            ||.|..|.|.:.||:||:..:.:|.|||...|:|....:|::|||||...:.::::::::|..::
Human   700 LFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMII 764

  Fly   571 -FLQPNVKDFFSHWLPSVP 588
             |....:.....:|..|||
Human   765 AFTSDMIPRLVYYWSFSVP 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	124/493 (25%)
ANO6	NP_001191732.1	Anoct_dimer	82..305	CDD:292796	54/237 (23%)
ANO6	NP_001191732.1	Anoctamin	308..892	CDD:282414	124/493 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920