DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axs and ANO4

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_011536213.1	Gene:	ANO4 / 121601	HGNCID:	23837	Length:	1121	Species:	Homo sapiens

Alignment Length:	867	Identity:	191/867 - (22%)
Similarity:	333/867 - (38%)	Gaps:	275/867 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KSPGPRTRNIIENQLFRRQRSLKLEALQ--RQRTLDSNDGV--------EGLGADTE------PF 54
            :...|:|.   :.::|  :|:::.|.||  ::.:|.::|.:        |.||...|      ||
Human   292 RKSNPQTE---KREVF--ERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMNVRMPF 351

  Fly    55 DKTHIVIIFTEKAKLRHCQDVEKIIQEFGIQTTLEIVGKTEKYL---YLSASVDTLLRLADAAEL 116
            .:.    |:....:.:....::|.|..|            .::|   .:....:|   |.|..|.
Human   352 RRK----IYYLPRRYKFMSRIDKQISRF------------RRWLPKKPMRLDKET---LPDLEEN 397

  Fly   117 EKMTTTHSMQKFNHGCISDFLLPGMGKEQILRYCEIPVLIKDVIQD----------GIKSYVQKG 171
            :..|...|.|:.:|..|.:       ||..........::..::|.          |:...:..|
Human   398 DCYTAPFSQQRIHHFIIHN-------KETFFNNATRSRIVHHILQRIKYEEGKNKIGLNRLLTNG 455

  Fly   172 YIEDMFPLHD-------------------ILYLERFNWNLKRTKLPIEDIRNYFGSSIGLYFGFI 217
            ..|..||||:                   :||....:|.:.....|::.:|.|||..|||||.::
Human   456 SYEAAFPLHEGSYRSKNSIRTHGAENHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWL 520

  Fly   218 EFYTKALIFPSLF-GILQYVF------------------DLNISLVCS----------------- 246
            .:|| .::||:.| |:..:::                  |:.:..||.
Human   521 GWYT-GMLFPAAFIGLFVFLYGVTTLDHSQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKV 584

  Fly   247 --------------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLD---KPR--SAYTGQLKPD 292
                          |..||.|:|||.|||:.|..:|.|..|:....:   :|:  :.|:.:.:.:
Human   585 THLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMN 649

  Fly   293 PITGKMTLHYPMRYTYLQMYCISYPV------VLGCVVAAGWFALYQFQIEAEVLADFGPDSWLL 351
            ||:||     |..|......|....|      .:.|||.|..|.:..:::  ..::.|....|.|
Human   650 PISGK-----PEPYQAFTDKCSRLIVSASGIFFMICVVIAAVFGIVIYRV--VTVSTFAAFKWAL 707

  Fly   352 Y----------VPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNFF 406
            .          ..|.:...:|.:.:..|||:|..|||||..||.|:::.....|:.||:.||...
Human   708 IRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNS 772

  Fly   407 SQFYIAFVL-----HDLRQLK----------------YQLMMQLLVFQLLCIA----QEIGIPLL 446
            |.|||||.|     |....|:                ..|.||:.:..:|...    .|:|.||:
Human   773 STFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLI 837

  Fly   447 AVLRQKYAEFRHREVAEE--KLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLFAA 509
                |.:  :..|:|.:|  ..|.|| .|::|:.:....::.| ..:::||::.:||||..:|.|
Human   838 ----QNW--WTRRKVRQEHGPERKIS-FPQWEKDYNLQPMNAY-GLFDEYLEMILQFGFTTIFVA 894

  Fly   510 VAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLLFLQP 574
            ..|.|.:.|||||:..:.:|.:|....::||.|.|||:||.|....|.:.::|:::|..::.:..
Human   895 AFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITS 959

  Fly   575 N-------------------------------------VKDF------------FS--------- 581
            :                                     :.||            ||
Human   960 DFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRY 1024

  Fly   582 ------------------HWLPSVPDLSFVI-FEHLLLGLKFLIHKVIHERPRWVRIGLLKADFE 627
                              .|......|:|:| ||||:..:|.||..:|.:.|:.:|..:.:..:.
Human  1025 RDYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYL 1089

  Fly   628 TSQ-----ALKQLKKFKAEANK 644
            ..:     .|::|:|.:.|..|
Human  1090 IQEMMYEAELERLQKERKERKK 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	143/595 (24%)
ANO4	XP_011536213.1	Anoct_dimer	277..502	CDD:292796	42/240 (18%)
ANO4	XP_011536213.1	Anoctamin	505..1087	CDD:282414	143/597 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920