Protein Alignment Axs and Ano6

DIOPT Version :9

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001240742.1
• Gene: Ano6 / 105722
• MGIID: 2145890
• Length: 932
• Species: Mus musculus
• Alignment Length: 678
• Identity: 157/678 - (23%)
• Similarity: 261/678 - (38%)
• Gaps: 218/678 - (32%)

  Fly   155 LIKDVIQDGIKSYVQKGYIEDMFPLHD-----------------ILYLERFNWNLKRT---KLPI 199
            ::.:|.:.||...|..|..:..|||||                 :||.|   |...|:   |.|:
Mouse   245 VMNNVNKFGINRLVSSGIYKAAFPLHDCRFNYESEDISCPSERYLLYRE---WAHPRSIYKKQPL 306

  Fly   200 EDIRNYFGSSIGLYFGFIEFYTKALIFPSLFGILQYVFD-------------------------- 238
            :.||.|:|..||:||.::.:||:.|:..::.|:..:::.
Mouse   307 DLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLDQDNCTWSKEVCDPDIGGQILMCP 371

  Fly   239 ----------LNISLVCS----------------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSS 277
                      |||:...|                |..||.|:|||.|||:.|...|.|.|:|:..
Mouse   372 QCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ 436

  Fly   278 LDKPRSAYTGQLK--------------PDPITGK---MTLHYPMRYTYLQMYCISYPVVLGCVVA 325
            .::.|..|..|..              |....||   :||.....:.::.:...|   |:|.:|
Mouse   437 EEQARPEYEAQCNHVVINEITQEEERIPFTTCGKCIRVTLCASAVFFWILLIIAS---VIGIIV- 497

  Fly   326 AGWFALYQFQIEAEVLA--DFGPDSWLLYV---------PVIVQSVLIAIFSWAYEKLATFLTNL 379
               :.|..|.:.:..|.  ..|.|....|:         ..|:..::|.|.:..|||:|..:||.
Mouse   498 ---YRLSVFIVFSTTLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNF 559

  Fly   380 ENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAF--------------VLHDLRQLK-------Y 423
            |..||::.|:.....|:.||:.||.:.|.|||||              :|...|..:       .
Mouse   560 ELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYLLGKYRSEECDPGGCLL 624

  Fly   424 QLMMQLLVFQ----LLCIAQEIGIPLLAVLRQKYAEFRHREVAEEKLRSISDLPRYEQSFYESGL 484
            :|..||.:..    :....||:.:|.:..|..:|    .|....||:     .||:||.::...:
Mouse   625 ELTTQLTIIMGGKAIWNNIQEVLLPWVMNLIGRY----KRVSGSEKI-----TPRWEQDYHLQPM 680

  Fly   485 DEYHSTYEDYLQVCIQFGFVVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIG 549
            .:....|| ||::.||||||.||.|..|.|.:.||:||:..:.:|.|||...|:|....:|::||
Mouse   681 GKLGLFYE-YLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIG 744

  Fly   550 AWQLAFELLSVMSLLSNCGLL---------------FLQP---------------------NVKD 578
            |||...:.::::::::|..::               |..|                     |:.|
Mouse   745 AWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNITD 809

  Fly   579 F--------------------------------FSH----WLPSVPDLSFVI-FEHLLLGLKFLI 606
            |                                :.|    |......|:|:| .||::..:||.|
Mouse   810 FKNTDKENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHIIYSVKFFI 874

  Fly   607 HKVIHERPRWVRIGLLKADFETSQALKQ 634
            ...|.:..:..:..:.:..:.|.:.|.:
Mouse   875 SYAIPDVSKITKSKIKREKYLTQKLLHE 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	138/598 (23%)
Ano6	NP_001240742.1	Anoct_dimer	84..306	CDD:292796	16/63 (25%)
		Anoctamin	309..893	CDD:282414	138/600 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920