Protein Alignment Axs and Ano10

DIOPT Version :9

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_011241230.1
• Gene: Ano10 / 102566
• MGIID: 2143103
• Length: 670
• Species: Mus musculus
• Alignment Length: 636
• Identity: 226/636 - (35%)
• Similarity: 331/636 - (52%)
• Gaps: 77/636 - (12%)

  Fly    63 FTEKAKLRHCQDVEKIIQEF------------GIQTTLE-IVGKTEK------YLYL-SASVDTL 107
            ||....:...|||:...:|:            |.|.... ::.|.||      .||| .||...|
Mouse    15 FTPLVVIELAQDVKDETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEKETLENQNLYLVGASNVRL 79

  Fly   108 LRLADAAELEKMTTTHSMQKFNHGCISDFLLPGMGKEQILRYCEIPVLIKDVIQD-------GIK 165
            |..|:|..|.|..|..:|:.|.:|...:|..........|...|...:||..:::       .|.
Mouse    80 LLGAEAVGLVKECTDAAMRAFTYGTRHNFKGFHDNNNDFLTMAECQFIIKHELENLRARDEKMIP 144

  Fly   166 SYVQ---------------KGYIEDMFPLHDILYLERF--NWNLKRTKL---PIEDIRNYFGSSI 210
            .|.|               .|.:..:|||||...|::.  .| ..|..|   ||:.||:|||.:|
Mouse   145 GYPQAKLYPGKSLMRRLLTSGIVTQVFPLHDTEALKKLEDTW-YTRFALKYQPIDSIRSYFGETI 208

  Fly   211 GLYFGFIEFYTKALIFPSLFGILQYVF-----DLNISLVCSFYVVWTTIFLELWKRKCAGYSYRW 270
            .|||||:|::|.|||..::.|:..|:|     |..: :..||.::|:|:.||:|||.||..:|||
Mouse   209 ALYFGFLEYFTFALIPMAIIGLPYYLFVWEDYDKYV-IFASFNLIWSTVILEVWKRGCANMTYRW 272

  Fly   271 GTIEMS-SLDKPRSAYTGQLKPDPITGKMTLHYPMRYTYLQMYCISYPVVLGCVVAAGWFALY-- 332
            ||:.|. ..::||..:.|.|..:.:||:....|......|::|.:|.|.|..|:    :|:||
Mouse   273 GTLVMKRQFEEPRPGFHGVLGINSVTGREEPLYSSYKRQLRIYLVSLPFVCLCL----YFSLYVM 333

  Fly   333 --QFQIEAEVLA---DFGPD--SWLLYVPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDR 390
              .|.:|...|:   |.|.:  |.|||||.||.:|:|.|.:..|...|.|||:.||||..|.|..
Mouse   334 MIYFDMEDWALSLHEDSGSEWTSLLLYVPSIVYAVVIEIMNRLYRYAAEFLTSWENHRLESAYQN 398

  Fly   391 HRVNKLMLFEIVNNFFSQFYIAFVLHDLRQLKYQLMMQLLVFQLLCIAQEIGIPLLAVLRQKYAE 455
            |.|.|:::|..:|.|.|.|||||||.|::.|:..|...|:..|:|....|..:|..  |::||..
Mouse   399 HLVLKVLVFNFLNCFASLFYIAFVLKDMKLLRQSLATLLITSQILNQVVESLLPYW--LQRKYCA 461

  Fly   456 FRHREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLFAAVAPFAAIGALL 520
            ...|:|  :.|:|..|...|||...|..:..|..|::|||::.:|||:|.||:.|.|.||..|:|
Mouse   462 RVKRKV--QALKSEVDTTLYEQVLLEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVL 524

  Fly   521 NNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLLFLQPNVKDFFSHWLP 585
            ||...|:.|..|:|.:||||||..:.:||.||||||.:||:|:::||.|:.:.|.|...|..
Mouse   525 NNFTEVNSDALKMCRVFKRPFAEPSASIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFPE--- 586

  Fly   586 SVPDLSFVI--FEHLLLGLKFLIHKVIHERPRWVRIGLLKADFETSQALKQ 634
            |..||..::  .||.||.|||::...|.::||.::..|.:.:||:.:||||
Mouse   587 SKTDLVLIVVAVEHALLALKFILAFAIPDKPRHIQQKLARLEFESLEALKQ 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	174/437 (40%)
Ano10	XP_011241230.1	Anoctamin	200..626	CDD:367984	174/437 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2513
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14314
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2559
Isobase	1	0.950	-	0	Normalized mean entropy	S5974
OMA	1	1.010	-	-		QHG57839
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0001419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100943
Panther	1	1.100	-	-	LDO	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4482
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790