Protein Alignment Axs and Ano1

DIOPT Version :9

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_006508521.1
• Gene: Ano1 / 101772
• MGIID: 2142149
• Length: 1066
• Species: Mus musculus
• Alignment Length: 874
• Identity: 185/874 - (21%)
• Similarity: 310/874 - (35%)
• Gaps: 305/874 - (34%)

  Fly     4 DAKSPGPRTRNIIENQLFRRQR--------SLKLEALQRQRTLDSNDGVEGLGADTEPFDKT--- 57
            ||.||........:::.|||:.        .|:||.       |.:..:.|:|     |.|.
Mouse   167 DAGSPEVPMDYHEDDKRFRREEYEGNLLEAGLELEN-------DEDTKIHGVG-----FVKIHAP 219

  Fly    58 -HIVIIFTEKAKLR-------HCQD-----------VEKI-------IQEFGIQTTLEI---VGK 93
             |::....|..||:       |..:           ::||       :.|...|||..:   ..:
Mouse   220 WHVLCREAEFLKLKMPTKKVYHISETRGLLKTINSVLQKITDPIQPKVAEHRPQTTKRLSYPFSR 284

  Fly    94 TEKYLY----LSASVDTLLRLADAAELEKMTT-THSMQKFNHGCISDFLLPGMGKEQIL----RY 149
            .:::|:    ..:..|:..|.....|:.|.|| |.:......|       .|..|:..|    |.
Mouse   285 EKQHLFDLTDRDSFFDSKTRSTIVYEILKRTTCTKAKYSMGQG-------EGRRKDSALLSKRRK 342

  Fly   150 CEIPVLIKDVIQDGIKSYVQKGYIEDMFPLHD--------------ILYLERFNWNLKRTKLPIE 200
            |.         :.||.|.:..|.....:||||              :||.|..::.:.....||:
Mouse   343 CG---------KYGITSLLANGVYSAAYPLHDGDYEGDNVEFNDRKLLYEEWASYGVFYKYQPID 398

  Fly   201 DIRNYFGSSIGLYFGFIEFYTKALIFPSLFGILQYVF-----DLNI------------------- 241
            .:|.|||..:||||.::..||:.||..|:.|::.:::     |.||
Mouse   399 LVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGCATVDENIPSMEMCDQRYNITMCPLCD 463

  Fly   242 --------SLVCS------------------FYVVWTTIFLELWKRKCAGYSYRWGTI-----EM 275
                    |..|:                  |..:|...|:|.||||....:|||...     |.
Mouse   464 KTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEE 528

  Fly   276 SSLDKPRSAYTGQ------------------LKPDP----------------ITGKMTL----HY 302
            :..|.||:.|..:                  :..:|                :|.|:.|    .:
Mouse   529 AVKDHPRAEYEARVLEKSLRKESRNKEKCRNVPEEPTNKWKQRVRTAMAGVKLTDKVKLTWRDRF 593

  Fly   303 PMRYTYLQ----MYCISYPVVLGCVVAAGWFALYQFQIEAEVLADFGPD------SWLLYVPVIV 357
            |..:|.|.    |..:::.:|||.::       |:....|.:..:..|.      ..:....||:
Mouse   594 PAYFTNLVSIIFMIAVTFAIVLGVII-------YRISTAAALAMNSSPSVRSNIRVTVTATAVII 651

  Fly   358 QSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAF--------- 413
            ..|:|.:....|..:|.:||.:|..:|...::.....|..|.:.||::...||:||
Mouse   652 NLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLTFKAFLLKFVNSYTPIFYVAFFKGRFVGRP 716

  Fly   414 -----VLHDLR-----------QLKYQLMMQLLVFQLLCIAQ----EIGIPLLAVLRQKYAEFRH 458
                 :....|           :|..||.:.:|..||:   |    |||||.:... .:|.:.|
Mouse   717 GDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLI---QNNLFEIGIPKMKKF-IRYLKLR- 776

  Fly   459 REVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLFAAVAPFAAIGALLNNV 523
            |:...::...:....|||..|   .|:.:.....:|:::.||||||.||.|..|.|.:.|||||:
Mouse   777 RQSPSDREEYVKRKQRYEVDF---NLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNI 838

  Fly   524 FAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNC-----------GLLFLQP--- 574
            ..:.:|..|.....:||.|.|||:||.|......:..::::.|.           .|::|..
Mouse   839 IEIRLDAKKFVTELRRPVAIRAKDIGIWYNILRGVGKLAVIINAFVISFTSDFIPRLVYLYMYSQ 903

  Fly   575 ---------------NVKDFFSHWLPSVP-DLSF------------------------------- 592
                           ||.||.:...|:.| ||.:
Mouse   904 NGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSEHKYDISKDFWAVLA 968

  Fly   593 ------VIFEHLLLGLKFLIHKVIHERPR 615
                  ::|::|::.:...:..||.:.|:
Mouse   969 ARLAFVIVFQNLVMFMSDFVDWVIPDIPK 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	132/613 (22%)
Ano1	XP_006508521.1	Anoct_dimer	112..397	CDD:374413	51/257 (20%)
		Anoctamin	400..1006	CDD:367984	132/613 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920