DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axs and ano6

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_005164519.1	Gene:	ano6 / 100535437	ZFINID:	ZDB-GENE-081104-64	Length:	910	Species:	Danio rerio

Alignment Length:	732	Identity:	177/732 - (24%)
Similarity:	287/732 - (39%)	Gaps:	191/732 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EDAKSPGPRTRNIIENQLFRR---QRSLKLEALQRQRTLDSNDGVEGLGADTEPFDKTHIVI-IF 63
            |::|:...:..::|..:..||   :.||..:.|..:.|....|  |.|.     |.|.|:.. :.
Zfish    73 EESKNGSNKKASVIRRKKRRREFFEGSLMNKGLHLEMTQSVVD--EKLF-----FVKLHMPFDVL 130

  Fly    64 TEKAKLRH------CQDVEKIIQEFGIQT-----TLEIVGKTEKYLYLSASVDTLLR--LADAAE 115
            ...|::.|      |.|:.....:....|     ..:::||...|.......|.|.|  |.:...
Zfish   131 CANAEVLHIKLPIKCNDLRTQSSKHNCCTKPFYPNEDVIGKEPDYFTAPFRKDLLNRFQLKEREG 195

  Fly   116 LEKMT-TTHSMQKFNHGCISDFLLPGMGKEQILRYCEIPVLIKDVIQDGIKSYVQKGYIEDMFPL 179
            .|..| |..|...:.....:::.:.|..|                 :.||...:..|..:..:||
Zfish   196 RELFTPTMRSRMVYYILSRAEYDIKGENK-----------------KFGITKLLAGGIYKAAYPL 243

  Fly   180 HD-----------------ILYLERFNW----NLKRTKLPIEDIRNYFGSSIGLYFGFIEFYTKA 223
            ||                 :||.|   |    |..:.: |::.||.|||..||:||.::.|||..
Zfish   244 HDCRFNVKSKEEDCPNERYLLYSE---WAHPKNFYKMQ-PLDLIRKYFGEKIGIYFAWLGFYTFM 304

  Fly   224 LIFPSLFGILQYVF-----------------------------DLN-----ISLVCS-------- 246
            |...:.||:..:::                             |.|     ::..|.
Zfish   305 LSLAAAFGLGCFIYGYRSRESSTWSKEVCDPDIGGQIVMCPQCDNNCPYWRLNTTCESSKRLCVF 369

  Fly   247 ----------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSL-DKPRSAYTGQL---KPDPIT-- 295
                      |..||.|:|||.|||..|...|:|.|:|.... ::||..|..:.   :..|||
Zfish   370 DNFGTLVFAVFMSVWVTLFLEFWKRYQAKLEYKWDTVEFQQQEEQPRPEYEARCTYERFSPITQS 434

  Fly   296 ---------GKMTLHYPMRY-----TYLQMYCISYPVVLGCVV-AAGWFALYQFQIEAEV----L 341
                     ||.     ||.     |.|....:....|:|.:| ....|.::..|:.:::    |
Zfish   435 NEKVPYTACGKC-----MRVSCGIGTVLFWILLIVASVVGVIVYRLAMFMVFSMQLRSDLNRKEL 494

  Fly   342 ADF----GPDSWLLYVPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIV 402
            ..|    .|.........|:..::|.|.:..|||:|.::|:.|..||:::|:.....|:.||:.|
Zfish   495 EPFREYITPQMATSITASIINVIIIMILNIVYEKVAVWITDFELPRTKTEYENSLTLKMFLFQFV 559

  Fly   403 NNFFSQFYIAFVLHD-------------------------LRQLKYQLMMQLLVFQLLCIAQEIG 442
            |.:.|.|||||....                         |.:|..||.:.:....:....||:.
Zfish   560 NFYSSCFYIAFFKGKIVGYPGEPVYWLGKFRNEECDPGGCLTELTTQLSIIMTGKAVWNNIQEVL 624

  Fly   443 IPLLAVLRQKYAEFRH-REVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVL 506
            :|.|     |...||| .:|..||.     :||:||.:....:......|| ||::.||||||.|
Zfish   625 LPWL-----KNLMFRHCTQVGSEKA-----IPRWEQDYQLQPMGTLGLFYE-YLEMVIQFGFVTL 678

  Fly   507 FAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLL- 570
            |.|..|.|.:.||:||:|.:.:|.||....|:|....:|::|||||...:.::::::::|..::
Zfish   679 FVASFPLAPLLALVNNLFEIRVDAWKFTTQFRRIVPEKAQDIGAWQPILQGVTILAVVTNTAIIA 743

  Fly   571 FLQPNVKDFFSHWLPSV 587
            |....:.....:|..||
Zfish   744 FTSDMIPRLVYYWAFSV 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	131/494 (27%)
ano6	XP_005164519.1	Anoct_dimer	56..280	CDD:292796	45/234 (19%)
ano6	XP_005164519.1	Anoctamin	283..873	CDD:282414	131/494 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920