Protein Alignment Axs and ano10l

DIOPT Version :10

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_002931722.2
• Gene: ano10l / 100495245
• XenbaseID: XB-GENE-22066158
• Length: 638
• Species: Xenopus tropicalis
• Alignment Length: 599
• Identity: 175/599 - (29%)
• Similarity: 293/599 - (48%)
• Gaps: 93/599 - (15%)

  Fly    98 LYLSASVDTLLRLADAAELEKMTTTHSMQKFNHGCISDFLLPGMGKEQI---LRYCEIPVLIK-- 157
            |.|||:...||:..:...|.|.....|:..|::...::||    ..|:|   |.:.|...|:|
 Frog    65 LLLSATECLLLQTTECLGLAKADHYKSITTFSYKHRNNFL----NSEKINIFLTFAEQQFLLKYE 125

  Fly   158 ----DVIQD----GIKSY-----------VQK-GYIEDMFPLHD----ILYLERFNWNLKRTKLP 198
                .::|:    |...|           :|| |.|...:|:||    .|..:|:...:.....|
 Frog   126 VENLKILQETCLPGYPEYRLYPGQHVVHFLQKWGIIVKFYPVHDKEKLKLLQKRWYKEISLAPQP 190

  Fly   199 IEDIRNYFGSSIGLYFGFIEFYTKALIFPSLF----GILQYVFDLNISLVCSFYVVWTTIFLELW 259
            |:.:|.|||..|.|||.|:.|:|.:||...|.    ..||...|..| :...|.|:|:|:.||||
 Frog   191 IDTVRAYFGEPIALYFSFLGFFTLSLIAMVLLSYIPAFLQDSSDKYI-IFAVFNVLWSTVTLELW 254

  Fly   260 KRKCAGYSYRWGTIEMSS-LDKPRSAYTGQLKPDPITGKMTLHYPMRYTYLQMYCISYPVVLGCV 323
            ||..|..:|.|||:.:.. |..||:.:.|.|..:||||::..|||.....::::.::.|.|  |:
 Frog   255 KRHSATKAYFWGTLNLKKYLKLPRAEFWGTLIKNPITGRLEPHYPHWKRKMRIFFVTVPSV--CI 317

  Fly   324 ---VAAGWFALYQFQIEAEVLADFGPDSWL---------------LYVPVIVQSVLIAIFSWAYE 370
               :|.....:|.:.           ::|:               ||:|.|..::.:.|.:.||.
 Frog   318 FLAIAIDGMDMYLYW-----------ETWIKHWYKQNTSKVAVIGLYLPSICYTLFMEILNSAYM 371

  Fly   371 KLATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAFVLHDLRQLKYQLMMQLLVFQLL 435
            |.||.||..||||..|.:..|...|:::|..:|.|....||.|.|.||:.|:.:|...|:|.|::
 Frog   372 KAATALTEFENHRLESSFQNHLTIKVLVFRFINCFGLLLYITFCLQDLQLLRKRLSSLLIVSQVI 436

  Fly   436 CIAQEIGIPLLAVLRQKYAEFRHREVAEEKLRS-------ISDLPRYEQSFYESGLDEYHSTYED 493
               .:....||..|:|:.           ||.|       :...|..::...|..:..|...::|
 Frog   437 ---NQFNESLLPYLKQRL-----------KLDSVWVKKSKVDTYPFIDEVVSEGDMYSYPGLFDD 487

  Fly   494 YLQVCIQFGFVVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELL 558
            |:::.:|||:|.||::|.|..|...:|||:..:..|.:|||.||::||:..|.:||.||.|||.|
 Frog   488 YMELLVQFGYVSLFSSVYPLTAALLILNNITEIRTDAFKLCQIFQKPFSYPAASIGVWQTAFETL 552

  Fly   559 SVMSLLSNCGLLFLQPNVKDFFSHWL--PSVPDLSFVIFEHLLLGLKFLIHKVIHERPRWVRIGL 621
            ..:|:::||.|:.:.|.::.....:.  |....|..:..||:|:.||.::...|.::|.|:::.:
 Frog   553 GFLSVITNCFLVAISPEIQAVCKKYEVGPEKILLYMLAAEHILIILKMILAFAIPDKPAWLQLKI 617

  Fly   622 LKADFETSQALKQL 635
            ::.::.:.:|||::
 Frog   618 MQMEYRSQEALKKM 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:461349	140/452 (31%)
ano10l	XP_002931722.2	Anoctamin	194..620	CDD:461349	140/453 (31%)