Protein Alignment Axs and ano7

DIOPT Version :10

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_031761694.1
• Gene: ano7 / 100494676
• XenbaseID: XB-GENE-6465418
• Length: 932
• Species: Xenopus tropicalis
• Alignment Length: 636
• Identity: 149/636 - (23%)
• Similarity: 240/636 - (37%)
• Gaps: 187/636 - (29%)

  Fly   163 GIKSYVQKGYIEDMFPLHD-------------------ILYLERFNWNLKRTKLPIEDIRNYFGS 208
            ||:..:|:|.....||||:                   ||......|:......|::.||:|||.
 Frog   256 GIERLLQEGIYSAAFPLHEGAHEMPEYQVPPESLNPRQILSQYWARWSQWYKYQPLDHIRDYFGE 320

  Fly   209 SIGLYFGFIEFYTKALIFPSLFGILQYVFDL-------------------------------NIS 242
            .:.:||.::.|||..|:..::.|.:.::..|                               .||
 Frog   321 KVAIYFAWLGFYTAWLLPAAIVGTVVFISGLVSMGSNTAAQQICQSGQQYRMCPLCDTCKNWFIS 385

  Fly   243 LVCS------------------FYVVWTTIFLELWKRKCAGYSYRWGTIE-MSSLDKPR---SAY 285
            .:|.                  |...|...|||.||||.|..::.|..:: ....::||   :|.
 Frog   386 DICPMAKVGYLFDHPGTVFFSVFMSFWAVTFLEYWKRKNATLAHHWDCMDFQEEEEQPRPEFAAM 450

  Fly   286 TGQLKPDPITGKMTLHYPMR----------YTYLQMYCISYPVVLGCVVAAGWFALYQF------ 334
            ..|::.:||||....::|.|          ...:.|.|:....::..::..|...:..:
 Frog   451 APQMEQNPITGVKEPYFPKRDRLSRVLTGSMVIIIMLCVVMIFLVSVIMYRGIVTMMMYHTGNSL 515

  Fly   335 -QIEAEVLADFGPDSWLLYVPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLML 398
             ..:|..:|:....        :|..|||.:....|..||..||..|.|||:|:::.....|:.:
 Frog   516 LMTQAGNIANISSS--------MVNLVLILLMGQVYTSLAEKLTRWEMHRTQSRHEDAFTFKVFV 572

  Fly   399 FEIVNNFFSQFYIAFV-------------LHDLR-----------QLKYQLMMQLLVFQLLCIAQ 439
            |:.||.:.|.||:||.             |..:|           :|..||.:.::..|::...|
 Frog   573 FQFVNFYSSPFYVAFFKGRFIGYPGRYGKLLGMRNEDCGPGGCLIELAQQLFVIMVGKQIVSNIQ 637

  Fly   440 EIGIPLLAVLRQK--YAEFRHREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFG 502
            |..:|.|...|||  .|:.|..::.||..|...|        ||  |.|....:|:||::.:|||
 Frog   638 EFLLPKLKSWRQKRQLAKVRGTQLREEPQRWGQD--------YE--LIECEGLFEEYLEMVLQFG 692

  Fly   503 FVVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNC 567
            |:.:|.|..|.|.:.|||||...:.:|..|....::||.|.||:.||.|.|..|.|:.:|::.|.
 Frog   693 FITIFVAAFPLAPLFALLNNWVEIRLDAQKFVCEYRRPVAERAQGIGVWFLILEALAQLSVIVNA 757

  Fly   568 GLLFLQPNVKDFFS--------------------------------------------------H 582
               ||.....||..                                                  :
 Frog   758 ---FLIAFTSDFLPRLLYQYEYNSDLSGYLNFTLAYSPRAYVSANHTVCRYKAFRDEDGNYTLFY 819

  Fly   583 WLPSVPDLSFVI-FEHLLLGLKFLIHKVIHERPRWVRIGLLKADFETSQAL 632
            |......|.|:| |||::......|..::.:.|..|.|.:.:..:...|||
 Frog   820 WKLLAVRLGFIIAFEHVVFFSLRCIDWMVPDIPESVEIKVKRERYLAKQAL 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:461349	134/567 (24%)
ano7	XP_031761694.1	Anoct_dimer	75..311	CDD:465044	11/54 (20%)
		Anoctamin	314..862	CDD:461349	134/568 (24%)