Protein Alignment Axs and ano4

DIOPT Version :10

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_004912950.2
• Gene: ano4 / 100488512
• XenbaseID: XB-GENE-6039527
• Length: 1157
• Species: Xenopus tropicalis
• Alignment Length: 872
• Identity: 189/872 - (21%)
• Similarity: 327/872 - (37%)
• Gaps: 288/872 - (33%)

  Fly    16 IENQLFRRQRSLKLEALQRQRTLDSNDGVEGLGADTEPFDKTHIV---IIFTEKAKLRHCQDVEK 77
            |:..|..|:.||:.|   ::...:.|...|||..:.|    :.||   |||.:
 Frog   321 IDYILVYRKTSLQSE---KREIFERNIRAEGLHLEKE----SSIVNSDIIFVK------------ 366

  Fly    78 IIQEFGIQTTLEIVGK------------------TEKYLYLSASVDTLLR--------------- 109
                  :....|::|:                  ..:|.::|.....|.|
 Frog   367 ------LHAPWEVLGRYAELMNVRMPFRRKIYYLHRRYKFMSRMEKQLSRFRGLLPKKPMRLDKE 425

  Fly   110 -LADAAELEKMTTTHSMQKFNHGCISDFLLPGMGKEQILRYCEIPVLIKDVIQD----------G 163
             :.|..|.:..|...|.|:.:|..|::       |:..........::..::|.          |
 Frog   426 KIPDLEENDCYTAPFSQQRIHHFIINN-------KDTFFNNATRTRIVHHILQRVKYEEGKNKIG 483

  Fly   164 IKSYVQKGYIEDMFPLHDILYLER-------------------FNWNLKRTKLPIEDIRNYFGSS 209
            :...:.....|..||||:..|..:                   .:|.:.....|::.:|.|||..
 Frog   484 LNRLLTNCTYEAAFPLHEGSYRSKNSIKTHGAENHRHLLFECWASWGVWYKYQPLDLVRRYFGEK 548

  Fly   210 IGLYFGFIEFYTKALIFPS----LFGILQYVFDL-------------NISL--VCS--------- 246
            |||||.::.:|| .::||:    ||..|..:|.|             ||::  :|.
 Frog   549 IGLYFAWLGWYT-GMLFPAAIVGLFVFLYGMFTLDSCQVSREICQATNITMCPLCDKYCPYMRLS 612

  Fly   247 ----------------------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLD---KPR--SA 284
                                  |..||.|:|||.|||:.|..:|.|..|:....:   :|:  :.
 Frog   613 DSCIYAKVTHLFDNSATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAK 677

  Fly   285 YTGQLKPDPITGKMTLHYPMRYTYLQMYCISYPV------VLGCVVAAGWFALYQFQIEAEVLAD 343
            |:.:.:.:||:||     |..|......|....|      .:.|||.|..|.:..:::  ..::.
 Frog   678 YSKKERVNPISGK-----PEPYQAFADKCSRLVVSASGIFFMICVVIAAVFGIVIYRV--VTVST 735

  Fly   344 FGPDSWLLY----------VPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLML 398
            |....|.|.          ..|.:...:|.:.:..||::|.||||||..||.|:::.....|:.|
 Frog   736 FAAFKWALIRNNSQVATTGTAVCINFCIIMLLNVLYERVALFLTNLEQPRTESEWENSFTLKMFL 800

  Fly   399 FEIVNNFFSQFYIAFVLHDLRQLKYQLMMQLLVFQL-----------LCIAQEIGIPLLAVLRQK 452
            |:.||...|.|||||.|..........:..:..::|           ||:  ::||  :.||:|.
 Frog   801 FQFVNLNSSTFYIAFFLGRFTGRPGAYLRLINKWRLEECHPSGCLIDLCL--QMGI--IMVLKQT 861

  Fly   453 YAEF-------------RHREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFV 504
            :..|             |.:...|..:...:.||::|:.:....::.| ..:|:||::.:||||.
 Frog   862 WNNFMELGYPLIQNWWTRRKLRQEHGIHGKTALPQWEKDYNLQPINPY-GLFEEYLEMILQFGFT 925

  Fly   505 VLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGL 569
            .:|.|..|.|.:.|||||:..:.:|.:|....::||.|.|||:||.|....|.:.::|:::|..:
 Frog   926 TIFVAAFPLAPLLALLNNIIEIRLDAYKFITQWRRPLASRAKDIGIWYGILEGIGILSVITNAFV 990

  Fly   570 LFLQPN-------------------------------------VKDFFSHW-------------- 583
            :.:..:                                     |.||.:|.
 Frog   991 IAVTSDFIPRLVYAYKYGPCAGQGRAGEKCMVGYVNASLSVFLVTDFENHSNSSRNGREFAEQYV 1055

  Fly   584 ----------LPSVPD---------------LSFVI-FEHLLLGLKFLIHKVIHERPRWVRIGLL 622
                      .||.|:               |:|:| ||||:..:|.||..:|.:.|:.:|..:.
 Frog  1056 KYCRYRDYRDPPSAPEPYAYTLQFWHVLAARLAFIIVFEHLVFFIKHLISYLIPDLPKDLRDRMR 1120

  Fly   623 KADFETSQ-----ALKQLKKFKAEANK 644
            :..:...:     .|::::|.|.|..|
 Frog  1121 REKYLIQEMMYEAELERVQKEKKERKK 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:461349	144/592 (24%)
ano4	XP_004912950.2	Anoct_dimer	313..538	CDD:465044	39/248 (16%)
		Anoctamin	541..1122	CDD:461349	144/593 (24%)