Protein Alignment Axs and ano6

DIOPT Version :9

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_002932853.1
• Gene: ano6 / 100486935
• XenbaseID: XB-GENE-982324
• Length: 909
• Species: Xenopus tropicalis
• Alignment Length: 737
• Identity: 158/737 - (21%)
• Similarity: 279/737 - (37%)
• Gaps: 224/737 - (30%)

  Fly   115 ELEKMTTTHSMQKFNHGCISD---FLLPGMGKEQILRY--CEIPVLIKDVIQD-GIKSYVQKGYI 173
            |.|..|......:.:...|.|   |..|.. :.:|:.:  ..:...||:.::. ||...:..|..
 Frog   176 EQEFFTAPFEKDRIDDFYIQDKETFFTPAT-RSRIVHFILSRVEYAIKENVKKFGINKLLDSGIY 239

  Fly   174 EDMFPLHD-----------------ILYLERFNWNLKRTKL---PIEDIRNYFGSSIGLYFGFIE 218
            :..|||||                 |||.:   |....:.|   |::.:|.|:|..:|:||.::.
 Frog   240 KAAFPLHDCNFNAVSVDSRCPSERYILYKQ---WAHPFSILKFQPLDLVRKYYGEKVGIYFAWLG 301

  Fly   219 FYTKALIFPSLFGILQYVFDLNISLVCS------------------------------------- 246
            |||:.||..::.|:..:::.:.....|:
 Frog   302 FYTRMLIVAAVVGVACFLYGVKSQETCTWSKEVCDPSIGGSIIMCPQCDKACNYWYLNITCESSK 366

  Fly   247 ---------------FYVVWTTIFLELWKRKCAGYSYRWGTIE-MSSLDKPRSAYTGQ---LKPD 292
                           |..:|.|:|||.|||:.|...|.|.|:| :...::|...|..:   :..:
 Frog   367 KLCIFDSFGTLVFAVFMGIWVTLFLEFWKRRQAELEYEWDTVEFLEQEEQPLPEYEAKCTHVVKN 431

  Fly   293 PITGKMTLHYPMRYT----YLQMYCISYPV---VLGCVVAAGWFALYQFQI-------------- 336
            .|| :...|.|  ||    .|::.|.:..|   :|..|.:.....:|:..:
 Frog   432 RIT-QQEEHVP--YTAFGKCLRVTCCTSAVFFWILLIVASVVGIIVYRLSVFLVFSATLPRAVNG 493

  Fly   337 -EAEVLADF-GPDSWLLYVPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLF 399
             ..|.:..: .|.:.......|:..::|.:.:..|||:|..:|:.|..|||::|:.....|:.||
 Frog   494 TNVEAIQKYLTPQTATTITASIISFIIIMLLNMLYEKVAIIITDFELPRTRTEYENSLTTKMFLF 558

  Fly   400 EIVNNFFSQFYIAFVLHDLRQL---------KYQ--------LMMQLLVFQLLCI---------A 438
            :.||.:.|.|||||....:...         ||:        .:::|.. ||..|         .
 Frog   559 QFVNYYSSCFYIAFFKGKIVGYPGDPVYWFGKYRNEECDPGGCLLELTT-QLTIIMGGKAIWNNI 622

  Fly   439 QEIGIPLLAVLRQKYAEFRHREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGF 503
            |||.:|.:..|..:......:.|          |||:|..:......:....|| ||::.|||||
 Frog   623 QEILVPWVKNLISRCRSSGSKAV----------LPRWEADYLLQPAGKLGLFYE-YLEMVIQFGF 676

  Fly   504 VVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCG 568
            |.||.|..|.|.:.||:||:..:.:|.||:...::|....:|::|||||...|.::::::::|..
 Frog   677 VTLFVASFPLAPVLALVNNLLEIRVDAWKITTQWRRMVPEKAQDIGAWQPIMEGVAILAVVTNAM 741

  Fly   569 LL---------------FLQP---------------------NVKDFFS---------------- 581
            ::               |..|                     :|.||.|
 Frog   742 IIAFTSDMIPRLVYYWSFSVPPYGNYTTNTMQGYINNTLSVFSVSDFQSESKPVAVNWFNPTVCR 806

  Fly   582 -------------------HWLPSVPDLSF-VIFEHLLLGLKFLIHKVIHERPRWVRIGLLKADF 626
                               :|......||| ::.||::..:||:|..:|.:.....:..:.:..:
 Frog   807 YRDFRYPPGHEHQYEHSVYYWHVVAAKLSFLIVMEHIVYFVKFIIAYIIPDVSNETKDKIKREKY 871

  Fly   627 ETSQAL--KQLKKFKAEANKMA 646
            .|.:.|  :.|:..|.:...:|
 Frog   872 LTQKLLHERHLRVMKKQMGGLA 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	129/597 (22%)
ano6	XP_002932853.1	Anoct_dimer	62..282	CDD:374413	23/109 (21%)
		Anoctamin	285..869	CDD:367984	129/598 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920