Protein Alignment Axs and Ano2

DIOPT Version :10

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_017448527.2
• Gene: Ano2 / 100361584
• RGDID: 1591606
• Length: 975
• Species: Rattus norvegicus
• Alignment Length: 679
• Identity: 153/679 - (22%)
• Similarity: 242/679 - (35%)
• Gaps: 239/679 - (35%)

  Fly   163 GIKSYVQKGYIEDMFPLHD--------------ILYLERFNWNLKRTKLPIEDIRNYFGSSIGLY 213
            ||.|.:.....|..:||||              :||.|...:.:.....||:.||.|||..||||
  Rat   275 GINSLIANNIYEAAYPLHDGEYDSPGDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLY 339

  Fly   214 FGFIEFYTKALIFPSLFGILQYVF-------DL-------------------------NISLVCS 246
            |.::..||..||..|:.|::.:::       |:                         |:|..|.
  Rat   340 FAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSKEMCDHQNAFTMCPLCDKSCDYWNLSSACG 404

  Fly   247 ------------------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLDK----PRSAYTGQL 289
                              |..:|.|:|||.|||......|.|   :::.:::    .|..|..::
  Rat   405 TARASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFW---DLTGIEEEEEHSRPEYETKV 466

  Fly   290 KPDPI--TGKMTLH-------------------------YPMR-YTYLQMYCISYPVVLGCVVAA 326
            :...:  :||..:.                         |.|. .:.|.|..:::.:|.|.:|
  Rat   467 REKLLKESGKSAVQKLEANSPEDDEDDEDKLTWKDRFPGYLMNSVSILFMIALTFSIVFGVIV-- 529

  Fly   327 GWFALYQFQIEAEVLADFGPDS----WLLYVPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQ 387
                 |:....|.:..:....|    .:....||:..|:|.|....|..:|.:||.:|..:|...
  Rat   530 -----YRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQT 589

  Fly   388 YDRHRVNKLMLFEIVNNFFSQFYIAF-------------VLHD------------LRQLKYQLMM 427
            ::...:.|..|.:.||.:...||:||             .:.|            |.:|..||.:
  Rat   590 FEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSI 654

  Fly   428 QLLVFQLLCIAQ----EIGIPLLAVLRQKYAEFRHREVAEEKLRSISD---LPRYEQSFYESGLD 485
            .:|..||:   |    |||:|.|..|        .|::.:|.....||   ..|.||...:..|:
  Rat   655 IMLGKQLI---QNNIFEIGVPKLKKL--------FRKLKDETEPGESDPDHSKRPEQWDLDYSLE 708

  Fly   486 EYHSTYEDYLQVCIQFGFVVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGA 550
            .|.....:|:::.||||||.||.|..|.|.:.||||||..|.:|..|.....:||.|.|.|:||.
  Rat   709 PYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGI 773

  Fly   551 WQLAFELLSVMSLLSNCGLLFLQPNVKDF---------FSH------------------------ 582
            |   |::||.:...|.....|:.....||         :||
  Rat   774 W---FDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGT 835

  Fly   583 -----------------------WLPSVPDLS-------------FVIFEHLLLGLKFLIHKVIH 611
                                   |.|:..:.|             .:||::|::.|..|:..:|.
  Rat   836 QPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSVLSARLAFVIIFQNLVMFLSVLVDWMIP 900

  Fly   612 ERPRWVRIGLLKADFETSQALKQLKKFKA 640
            :.|              :....|:||.|:
  Rat   901 DIP--------------TDISDQIKKEKS 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:461349	136/607 (22%)
Ano2	XP_017448527.2	Anoct_dimer	68..325	CDD:465044	11/49 (22%)
		Anoctamin	328..913	CDD:461349	138/622 (22%)