DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axs and ano11

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_009295190.1	Gene:	ano11 / 100007289	ZFINID:	ZDB-GENE-090313-245	Length:	893	Species:	Danio rerio

Alignment Length:	835	Identity:	183/835 - (21%)
Similarity:	307/835 - (36%)	Gaps:	246/835 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KLEALQRQRTLDSNDGVEGLGADTEPFDKTHIVIIFTEKAKLRHCQDVEKII---QEFGIQTTLE 89
            :::..:::|:....:..||.....:...::.     ..||:|...:|  |.|   |..|:....|
Zfish    88 EVKVRRKRRSRGQAEASEGAAEPAQEESRSE-----RRKAQLARWRD--KFILNLQTAGLLMEKE 145

  Fly    90 ---IVGKTEKYLYLSASVDTLLRLADAAELEKMTTTHSMQKFNHGCISDFLLPGMGKEQILRYCE 151
               .|.||..||.|.|..|.|:..|:...|...........||...            ::|:...
Zfish   146 ESSSVKKTIHYLKLHAPWDVLVYYAEELCLRAPLQAQPHPDFNTSA------------RVLQKLW 198

  Fly   152 IPVLIKDVIQD------------------------------------------------------ 162
            :|.::||.:.:
Zfish   199 VPNIMKDSVPNRPVDYYTCAFRKSKMEKFLGSDDRENYFTSTQRHRIVYEILARTAYGRRKRAEV 263

  Fly   163 GIKSYVQKGYIEDMFPLHD-------------------ILYLERFNWNLKRTKL-PIEDIRNYFG 207
            |:...::.|.....||||:                   :||....:| ||..|. |::.||.|||
Zfish   264 GVARLLRDGAFTGAFPLHEGPFKLPSCDTQPDQLNKRQVLYHYWASW-LKWCKYQPLDHIREYFG 327

  Fly   208 SSIGLYFGFIEFYTKALIFPSLFGILQYVFDL-------------------------------NI 241
            ..|.|||.::.|||..|:..:|.|...:|..:                               |:
Zfish   328 EKIALYFAWLGFYTAWLLPAALVGTCVFVSGILTMGSNTPAKEICESGGLYLMCPLCETCKPWNM 392

  Fly   242 SLVCS------------------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLDKPR----SA 284
            |.:|.                  |..:|...|||.||||.|..::.|..::....::|.    :|
Zfish   393 SDICPMAKVGYLFDHPGTVFFSVFMSLWAVTFLEYWKRKNATLAHHWDCMDFHEDEEPPRPEFAA 457

  Fly   285 YTGQLKPDPITGKMTLHYPMRYTYLQMYCISYPVVLG-CVVAAGWFALYQFQIEAEVLADFGPDS 348
            ....::.:|:||....::|.:....:|...|..:|:. |||......:..::....|:. |...|
Zfish   458 MAPAMEENPVTGVKEPYFPEKARISRMLTGSMVIVIMLCVVMIFLVTVIIYRSIVSVMM-FETGS 521

  Fly   349 WLLYV---------PVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLFEIVNN 404
            .:|..         ..:|...||.:....|..||..||..|.|||::||:.....|:.:|:.||.
Zfish   522 SVLRTQAGNIANISSTLVNLALILLMGQVYTALAEQLTKWEMHRTQTQYEDAFTFKVFIFQFVNF 586

  Fly   405 FFSQFYIAF-------------VLHDLR-----------QLKYQLMMQLLVFQLLCIAQEIGIPL 445
            :.|.||:||             .|..:|           :|..||.:.::..||:...||..||.
Zfish   587 YSSPFYVAFFKGRFVGYPGHYGTLFGMRNEDCGPGGCLIELAEQLCIIMVGKQLINNIQEFVIPK 651

  Fly   446 LAVLRQKYAEFRHREVAE-EKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLFAA 509
            :...|||      |.:|. :|.:...:..|:||. ||  |......:::||::.:||||:.:|.|
Zfish   652 IKAWRQK------RALASVKKAQKTQEPERWEQD-YE--LIPCEGLFDEYLEIVLQFGFITIFVA 707

  Fly   510 VAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLL---- 570
            ..|.|.:.|||||...|.:|..|....::||.|.||::||.|.:..|.||.:|::.|..|:
Zfish   708 AFPLAPLFALLNNWVEVRLDAHKFVCEYRRPVAERAQHIGVWFIILEALSHVSVVVNAFLIAFTS 772

  Fly   571 -------------------------------------------FLQPNVKDFFSHWLPSVPDLSF 592
                                                       |...|.|....:|......|.|
Zfish   773 DFLPRLLYQYKFNNDLHGYVNFTLAYSPPSYNHSSHTVCRYKAFRDENGKYKLVYWELLAVRLGF 837

  Fly   593 VI-FEHLLLGLKFLIHKVIHERPRWVRIGLLKADFETSQALKQLKKFKAEANKMA 646
            :| |||::..:..:|..::.:.|..:::.:.:..:...|||...::...:|.::|
Zfish   838 IIAFEHVVFFVLRVIDWMVPDIPESLQLKIKRERYLAKQALADNQEALLQAKRLA 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	136/556 (24%)
ano11	XP_009295190.1	Anoct_dimer	73..319	CDD:292796	41/250 (16%)
ano11	XP_009295190.1	Anoctamin	322..871	CDD:282414	136/558 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920