DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment r and TMEM116

DIOPT Version :9

Sequence 1:NP_001285343.1 Gene:r / 32640 FlyBaseID:FBgn0003189 Length:2224 Species:Drosophila melanogaster
Sequence 2:XP_024305025.1 Gene:TMEM116 / 89894 HGNCID:25084 Length:394 Species:Homo sapiens


Alignment Length:296 Identity:55/296 - (18%)
Similarity:106/296 - (35%) Gaps:72/296 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   371 MESIQQKDLTIPQLIEQRLRPTTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRE 435
            |:..|....|.|.:|:...|....|...:.::|   |:|.:....:|...|...:.||:.|.:  
Human   150 MKHTQSGQSTSPLVIDYTCRVCQMAFVFSSLIP---LLLMTPVFCLGNTSECFQNFSQSHKCI-- 209

  Fly   436 SNIQTVLINPNIATVQ----TSKGMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGV 496
                 ::.:|..|..:    .:..:....||.                 |:.:..|         
Human   210 -----LMHSPPSAMAELPPSANTSVCSTLYFY-----------------GIAIFLG--------- 243

  Fly   497 QLERAGVFSKYNVRILGTPIQSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYP 561
                :.|.|...:.:|....|::.     |.|.:....:|.:      .::|...:|...|. ||
Human   244 ----SFVLSLLTIMVLLIRAQTLY-----KKFVKSTGFLGSE------QWAVIHIVDQRVRF-YP 292

  Fly   562 VMARAAFSLGGLG--------SGFANNEEELQSLAQQALAHSSQLIVDKSLKGW-----KEVEYE 613
            |   |.|...|..        :...:.:..:.....|||..:||.:::..:.||     .:::.|
Human   293 V---AFFCCWGPAVILMIIKLTKPQDTKLHMALYVLQALTATSQGLLNCGVYGWTQHKFHQLKQE 354

  Fly   614 VVRDAYNNCITVCNMENFDPLGIHTGESIVVAPSQT 649
            ..|||......:|:.:.|...|:::.||.:..|:.|
Human   355 ARRDADTQTPLLCSQKRFYSRGLNSLESTLTFPAST 390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rNP_001285343.1 CPSaseIIsmall 7..376 CDD:273580 1/4 (25%)
CPSase_sm_chain 7..151 CDD:279346
GATase1_CPSase 196..371 CDD:153215 55/296 (19%)
CPSaseII_lrg 403..1455 CDD:273581 48/264 (18%)
CPSase_L_D2 524..726 CDD:280881 30/139 (22%)
CPSase_L_D3 815..935 CDD:280882
P-loop_NTPase 947..>1149 CDD:304359
ATP-grasp_4 1084..1265 CDD:302634
MGS_CPS_I_III 1327..1453 CDD:238711
CAD_DHOase 1475..1821 CDD:238641
PLN02527 1918..2220 CDD:178142
OTCace_N 1919..2060 CDD:280825
OTCace 2067..2216 CDD:278609
TMEM116XP_024305025.1 7tm_GPCRs <235..342 CDD:333717 24/151 (16%)
TM helix 6 283..307 CDD:320094 8/27 (30%)
TM helix 7 316..342 CDD:320094 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0458
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.