DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment r and CPA1

DIOPT Version :9

Sequence 1:	NP_001285343.1	Gene:	r / 32640	FlyBaseID:	FBgn0003189	Length:	2224	Species:	Drosophila melanogaster
Sequence 2:	NP_014947.3	Gene:	CPA1 / 854479	SGDID:	S000005829	Length:	411	Species:	Saccharomyces cerevisiae

Alignment Length:	387	Identity:	176/387 - (45%)
Similarity:	238/387 - (61%)	Gaps:	24/387 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASTDCYLALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYP 66
            |:|.....:::|....|.|||    .|:|   ..||.||.|.:|||.|::||.||.|||||.|.|
Yeast     4 AATKATFCIQNGPSFEGISFG----ANKS---VAGETVFTTSLVGYPESMTDPSYRGQILVFTQP 61

  Fly    67 LIGNYGVPAPD-EDEHGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQ 130
            ||||||||:.: .||:.|..:||  ...:....:||.|.|.:..||...::|..|.::..|..|.
Yeast    62 LIGNYGVPSGEARDEYNLLKYFE--SPHIHVVGIVVAEYAYQYSHWTAVESLAQWCQREGVAAIT 124

  Fly   131 DIDTRALTKKLREQGSMLGKI-VYEKPPVEGLPKSSFVDPNVRNLAKECSVKER-QVYGNPNGKG 193
            .:|||.|.:.||||||.||:| :.:..||      .:|:|...||..:.:.|:. .|...|....
Yeast   125 GVDTRELVQYLREQGSSLGRITLADHDPV------PYVNPMKTNLVAQVTTKKPFHVSALPGKAK 183

  Fly   194 PRIAILDCGLKLNQLRCLLQRGASVTLLPWSARLED--EQFDALFLSNGPGNPESCDQIVQQVRK 256
            ..:|::|||:|.|.:|||::|||:||:.|:..|::|  .:||.:||||||||||.|...:..||:
Yeast   184 ANVALIDCGVKENIIRCLVKRGANVTVFPYDYRIQDVASEFDGIFLSNGPGNPELCQATISNVRE 248

  Fly   257 VIEEGQK---PVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDL 318
            ::.....   |:|||||||||||.|.|.||:|:|||||.||:|.:...||:|.:||||||||||.
Yeast   249 LLNNPVYDCIPIFGICLGHQLLALASGASTHKLKYGNRAHNIPAMDLTTGQCHITSQNHGYAVDP 313

  Fly   319 EQLP-DGWSELFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQQKDL 379
            |.|| |.|...|||.||.:|||::|..:|.||.|||||...||.||..|||.|.::|::..|
Yeast   314 ETLPKDQWKPYFVNLNDKSNEGMIHLQRPIFSTQFHPEAKGGPLDTAILFDKFFDNIEKYQL 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_001285343.1	CPSaseIIsmall	7..376	CDD:273580	173/377 (46%)
		CPSase_sm_chain	7..151	CDD:279346	62/144 (43%)
		GATase1_CPSase	196..371	CDD:153215	99/180 (55%)
		CPSaseII_lrg	403..1455	CDD:273581
		CPSase_L_D2	524..726	CDD:280881
		CPSase_L_D3	815..935	CDD:280882
		P-loop_NTPase	947..>1149	CDD:304359
		ATP-grasp_4	1084..1265	CDD:302634
		MGS_CPS_I_III	1327..1453	CDD:238711
		CAD_DHOase	1475..1821	CDD:238641
		PLN02527	1918..2220	CDD:178142
		OTCace_N	1919..2060	CDD:280825
		OTCace	2067..2216	CDD:278609
CPA1	NP_014947.3	CPSaseIIsmall	8..372	CDD:273580	173/378 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345393
Domainoid	1	1.000	129	1.000	Domainoid score	I1144
eggNOG	1	0.900	-	-		E1_COG0458
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740