DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment r and CPA2

DIOPT Version :9

Sequence 1:	NP_001285343.1	Gene:	r / 32640	FlyBaseID:	FBgn0003189	Length:	2224	Species:	Drosophila melanogaster
Sequence 2:	NP_012643.3	Gene:	CPA2 / 853573	SGDID:	S000003870	Length:	1118	Species:	Saccharomyces cerevisiae

Alignment Length:	1092	Identity:	586/1092 - (53%)
Similarity:	753/1092 - (68%)	Gaps:	49/1092 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 PTTPAIDSAPVMPR------KVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIAT 449
            ||..|..:....|:      .||::|||||||||||||||||||||||::|.|..|:|:||||||
Yeast    10 PTNSAFTTEDYKPQLVEGVNSVLVIGSGGLSIGQAGEFDYSGSQAIKALKEDNKFTILVNPNIAT 74

  Fly   450 VQTSKGMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVQLERAGVFSKYNVRILGT 514
            .|||..:|||.|:||:||.|:..:|:.|||:.:||||||||.|||||.|:.:||.:||||::|||
Yeast    75 NQTSHSLADKIYYLPVTPEYITYIIELERPDAILLTFGGQTGLNCGVALDESGVLAKYNVKVLGT 139

  Fly   515 PIQSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYPVMARAAFSLGGLGSGFAN 579
            ||:::|.:|||.|||..:.:|...:|.|.|..:|.:||:||.|:.|||:.|:|::||||||||||
Yeast   140 PIKTLITSEDRDLFASALKDINIPIAESFACETVDEALEAAERVKYPVIVRSAYALGGLGSGFAN 204

  Fly   580 NEEELQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCITVCNMENFDPLGIHTGESIVV 644
            |..|::.||.|:|:.:.|::|:||||||||||||||||...|||||||||||||||:|||:|:|.
Yeast   205 NASEMKELAAQSLSLAPQILVEKSLKGWKEVEYEVVRDRVGNCITVCNMENFDPLGVHTGDSMVF 269

  Fly   645 APSQTLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKATG 709
            ||||||||.|:.||||.|:|:|||.||:||||:||||.|....|.:|||||||||||||||||||
Yeast   270 APSQTLSDEEFHMLRSAAIKIIRHLGVIGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATG 334

  Fly   710 YPLAYVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSVG 774
            |||||.|||:.||..||::.|.:|..|.|.|||||||.|.|||:|||:||..|.:.|||||||||
Yeast   335 YPLAYTAAKIGLGYTLPELPNPITKTTVANFEPSLDYIVAKIPKWDLSKFQYVDRSIGSSMKSVG 399

  Fly   775 EVMAIGRNFEEAFQKALRMVDSDVLGFDPDVVPLNKEQLAEQLSEPTDRRPFVIAAAL-QLGMSL 838
            ||||||||:|||||||||.||..:|||.....  ..:||.|.|..|||||...|..|| ....::
Yeast   400 EVMAIGRNYEEAFQKALRQVDPSLLGFQGSTE--FGDQLDEALRTPTDRRVLAIGQALIHENYTV 462

  Fly   839 RELHQLTNIDYWFLEKLERIILLQSLLTRNGSRTDAA--LLLKAKRFGFSDKQIAKYIKS----- 896
            ..:::|:.||.|||.|...|:.:...|....|.:|.:  ||.:||:.||||||||..|..
Yeast   463 ERVNELSKIDKWFLYKCMNIVNIYKELESVKSLSDLSKDLLQRAKKLGFSDKQIAVTINKHASTN 527

  Fly   897 -TELAVRHQRQEFGIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDFPGGHTIVVGSGVYRIG 960
             .||.:|..|:..||.|.||:|||:|.|:||.|||||.|||.:::||:|.....:|:||||||||
Yeast   528 INELEIRSLRKTLGIIPFVKRIDTLAAEFPAQTNYLYTTYNATKNDVEFNENGMLVLGSGVYRIG 592

  Fly   961 SSVEFDWCAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGI 1025
            ||||||||||...:.||...:.||||||||||||||:|..|||||||:|:|.||||||:|.|||.
Yeast   593 SSVEFDWCAVNTAKTLRDQGKKTIMINYNPETVSTDFDEVDRLYFEELSYERVMDIYELEQSEGC 657

  Fly  1026 ILSMGGQLPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIE 1090
            |:|:|||||.|||:.|:.....::||:|..||.||||.|||.:||...:.||.|.|||:::.|..
Yeast   658 IISVGGQLPQNIALKLYDNGCNIMGTNPNDIDRAENRHKFSSILDSIDVDQPEWSELTSVEEAKL 722

  Fly  1091 FCEEVGYPCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVA 1155
            |..:|.||.|:|||||||||||:|..:.::|:..|..||:||.:||||:|||:..|:||||||||
Yeast   723 FASKVNYPVLIRPSYVLSGAAMSVVNNEEELKAKLTLASDVSPDHPVVMSKFIEGAQEIDVDAVA 787

  Fly  1156 SDGRILCMAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAK 1220
            .:|.:|..|:||||||||||||||:||.|||.|:.:...|:|.|...:|....:|||||||:| |
Yeast   788 YNGNVLVHAISEHVENAGVHSGDASLVLPPQHLSDDVKIALKDIADKVAKAWKITGPFNMQII-K 851

  Fly  1221 NNE--LKVIECNVRVSRSFPFVSKTLDHDFVATATRAIVGLDV--EPLDVLHGVGK----VGVKV 1277
            :.|  |||||||:|.|||||||||.|..:|:..|.:|.:|.|:  :|:|::  :.|    |..||
Yeast   852 DGEHTLKVIECNIRASRSFPFVSKVLGVNFIEIAVKAFLGGDIVPKPVDLM--LNKKYDYVATKV 914

  Fly  1278 PQFSFSRLAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMST-GFQI--PKNAVLLSIGSFKHK 1339
            |||||:||||||..||||||||||||.||.:..|:|..|:.|| .|.:  |.:.:|....:.:..
Yeast   915 PQFSFTRLAGADPFLGVEMASTGEVASFGRDLIESYWTAIQSTMNFHVPLPPSGILFGGDTSREY 979

  Fly  1340 MELLPSIRDLAKMGYKLYASMGTGDFYAEHGVNVESVQWTFDKTTPDDINGELRHLAEFLANKQF 1404
            :..:.||  :|.:||::|.:..|...|.:..:..::.:.:..|...:|    .|.|.|.......
Yeast   980 LGQVASI--VATIGYRIYTTNETTKTYLQEHIKEKNAKVSLIKFPKND----KRKLRELFQEYDI 1038

  Fly  1405 DLVINLPMSGGGARRVSSFMTHGYRTRRLAVDYSIPLVTD-------VKCTK 1449
            ..|.||     .::|..|.....|..||.|:|::|||..:       .||.|
Yeast  1039 KAVFNL-----ASKRAESTDDVDYIMRRNAIDFAIPLFNEPQTALLFAKCLK 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_001285343.1	CPSaseIIsmall	7..376	CDD:273580
		CPSase_sm_chain	7..151	CDD:279346
		GATase1_CPSase	196..371	CDD:153215
		CPSaseII_lrg	403..1455	CDD:273581	583/1080 (54%)
		CPSase_L_D2	524..726	CDD:280881	133/201 (66%)
		CPSase_L_D3	815..935	CDD:280882	55/128 (43%)
		P-loop_NTPase	947..>1149	CDD:304359	118/201 (59%)
		ATP-grasp_4	1084..1265	CDD:302634	101/184 (55%)
		MGS_CPS_I_III	1327..1453	CDD:238711	30/130 (23%)
		CAD_DHOase	1475..1821	CDD:238641
		PLN02527	1918..2220	CDD:178142
		OTCace_N	1919..2060	CDD:280825
		OTCace	2067..2216	CDD:278609
CPA2	NP_012643.3	CPSaseII_lrg	23..1084	CDD:273581	580/1076 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	224	1.000	Domainoid score	I436
eggNOG	1	0.900	-	-		E1_COG0458
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55291
OrthoFinder	1	1.000	-	-		FOG0001016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100435
Panther	1	1.100	-	-	O	PTHR11405
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1046
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.850