DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment r and URA2

DIOPT Version :9

Sequence 1:	NP_001285343.1	Gene:	r / 32640	FlyBaseID:	FBgn0003189	Length:	2224	Species:	Drosophila melanogaster
Sequence 2:	NP_012405.2	Gene:	URA2 / 853311	SGDID:	S000003666	Length:	2214	Species:	Saccharomyces cerevisiae

Alignment Length:	2268	Identity:	1110/2268 - (48%)
Similarity:	1494/2268 - (65%)	Gaps:	137/2268 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNYG 72
            |.|:|||||.|||||       ::....||:|||||||||.|::||.||.|||||:||||:||||
Yeast    24 LELKDGTVLQGYSFG-------AEKSVAGELVFQTGMVGYPESVTDPSYEGQILVITYPLVGNYG 81

  Fly    73 VP---APDEDEHGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQDIDT 134
            ||   ..||....||.:||  ...:....||:....:|..|:....:|..||:...:|.:..:||
Yeast    82 VPDMHLRDELVEELPRYFE--SNRIHIAGLVISHYTDEYSHYLAKSSLGKWLQNEGIPAVYGVDT 144

  Fly   135 RALTKKLREQGSMLGKIVYEKPPVE-GLPKSS----------FVDPNVRNLAKECSVKERQVY-- 186
            |:|||.||:.|||||::..||...: .:.:||          :|||||:||..:.|:.|.::|
Yeast   145 RSLTKHLRDAGSMLGRLSLEKSGSDRTISRSSSWRSAFDVPEWVDPNVQNLVSKVSINEPKLYVP 209

  Fly   187 ----------GNPNGKGPRIAILDCGLKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGP 241
                      ..|:||..||..:|.|:|.||:||.::||..:.::||:.....|.:|.||:||||
Yeast   210 PADNKHIELQTGPDGKVLRILAIDVGMKYNQIRCFIKRGVELKVVPWNYDFTKEDYDGLFISNGP 274

  Fly   242 GNPESCDQIVQQVRKVIEEGQKPVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCL 306
            |:|...|.:.|::..|:|..:.|||||||||||:|:|.|.||.|:|:||||||:||....:|||.
Yeast   275 GDPSVLDDLSQRLSNVLEAKKTPVFGICLGHQLIARAAGASTLKLKFGNRGHNIPCTSTISGRCY 339

  Fly   307 MTSQNHGYAVDLEQLPDGWSELFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFM 371
            :||||||:|||::.|..||..|||||||.:||||.|:..||||||||||...||:|||||||||:
Yeast   340 ITSQNHGFAVDVDTLTSGWKPLFVNANDDSNEGIYHSELPYFSVQFHPESTPGPRDTEFLFDVFI 404

  Fly   372 ESIQQ-------KDLTIP-QLIEQRLRPTTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQ 428
            :::::       |.:..| .|:|..:: ..|.|::     :|||:||||||||||||||||||||
Yeast   405 QAVKEFKYTQVLKPIAFPGGLLEDNVK-AHPRIEA-----KKVLVLGSGGLSIGQAGEFDYSGSQ 463

  Fly   429 AIKAMRESNIQTVLINPNIATVQTSKGMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALN 493
            ||||::|..|.|:||||||||:|||||:|||.||:|:|..:|.:||..|||:.:.:||||||||:
Yeast   464 AIKALKEEGIYTILINPNIATIQTSKGLADKVYFVPVTAEFVRKVILHERPDAIYVTFGGQTALS 528

  Fly   494 CGVQLERAGVFSKYNVRILGTPIQSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRL 558
            .|:.::  ..|....|::|||||.:||.||||:||:..::||.|:.|.|:|..||.:||.|...:
Yeast   529 VGIAMK--DEFEALGVKVLGTPIDTIITTEDRELFSNAIDEINEKCAKSQAANSVDEALAAVKEI 591

  Fly   559 GYPVMARAAFSLGGLGSGFANNEEELQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCI 623
            |:||:.|||::||||||||||||:||..|...|.:.|.|::|:||:||||||||||||||::|||
Yeast   592 GFPVIVRAAYALGGLGSGFANNEKELVDLCNVAFSSSPQVLVEKSMKGWKEVEYEVVRDAFDNCI 656

  Fly   624 TVCNMENFDPLGIHTGESIVVAPSQTLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQY 688
            ||||||||||||||||:||||||||||||.:|.|||:||:.||||.||||||||||||.|.|:.|
Yeast   657 TVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPVSKDY 721

  Fly   689 YIIEVNARLSRSSALASKATGYPLAYVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPR 753
            .|||||||||||||||||||||||||.||||.|.:||.::|||||.:|.|||||||||||||:||
Yeast   722 CIIEVNARLSRSSALASKATGYPLAYTAAKLGLNIPLNEVKNSVTKSTCACFEPSLDYCVVKMPR 786

  Fly   754 WDLAKFVRVSKHIGSSMKSVGEVMAIGRNFEEAFQKALRMVDSDVLGF---DPDVVPLNKEQLAE 815
            |||.||.|||..:.||||||||||:|||.||||.|||:|..:...|||   |.|:      .:..
Yeast   787 WDLKKFTRVSTELSSSMKSVGEVMSIGRTFEEAIQKAIRSTEYANLGFNETDLDI------DIDY 845

  Fly   816 QLSEPTDRRPFVIAAAL-QLGMSLRELHQLTNIDYWFLEKLERIILLQSLLTRNGSRTD--AALL 877
            :|:.|||.|.|.||.|. :.|.|:.::.::|.||.|||.||..::.....::..|::.:  :.:|
Yeast   846 ELNNPTDMRVFAIANAFAKKGYSVDKVWEMTRIDKWFLNKLHDLVQFAEKISSFGTKEELPSLVL 910

  Fly   878 LKAKRFGFSDKQIAKYIKSTELAVRHQRQEFGIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDV 942
            .:||:.||.|:|||:::.|.|:|:|..|:|:||.|.||||||||.|:||.|||||.|||...||:
Yeast   911 RQAKQLGFDDRQIARFLDSNEVAIRRLRKEYGITPFVKQIDTVAAEFPAYTNYLYMTYNADSHDL 975

  Fly   943 DFPGGHTIVVGSGVYRIGSSVEFDWCAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEE 1007
            .|.....:|:||||||||||||||||||..:|.||.....|||:||||||||||||..||||||.
Yeast   976 SFDDHGVMVLGSGVYRIGSSVEFDWCAVTAVRTLRANNIKTIMVNYNPETVSTDYDEADRLYFET 1040

  Fly  1008 ISFEVVMDIYEMENSEGIILSMGGQLPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRK 1072
            |:.|.|:||||:|||.|:::|||||..|||||.|||:..|:|||||:.||.||||:|||||||:.
Yeast  1041 INLERVLDIYEIENSSGVVVSMGGQTSNNIAMTLHRENVKILGTSPDMIDSAENRYKFSRMLDQI 1105

  Fly  1073 GILQPRWKELTNLQSAIEFCEEVGYPCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPV 1137
            |:.||.|||||::..|..|.|:||||.||||||||||||||..||..|||:|||.|.||||::||
Yeast  1106 GVDQPAWKELTSMDEAESFAEKVGYPVLVRPSYVLSGAAMNTVYSKNDLESYLNQAVEVSRDYPV 1170

  Fly  1138 VISKFLTEAKEIDVDAVASDGRILCMAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCD 1202
            ||:|::..||||::||||.:|.::...|||||||||||||||||:.|||||..||::.|...|..
Yeast  1171 VITKYIENAKEIEMDAVARNGELVMHVVSEHVENAGVHSGDATLIVPPQDLAPETVDRIVVATAK 1235

  Fly  1203 LASVLDVTGPFNMQLIAKNNELKVIECNVRVSRSFPFVSKTLDHDFVATATRAIVGLDVEPLDVL 1267
            :...|.:|||:|:|.|||:||:||||||||.||||||:||.:..:.:..||:||:||.:.|
Yeast  1236 IGKALKITGPYNIQFIAKDNEIKVIECNVRASRSFPFISKVVGVNLIELATKAIMGLPLTP---- 1296

  Fly  1268 HGVGK-----VGVKVPQFSFSRLAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKN 1327
            :.|.|     |.||||||||.||||||..||||||||||||.||.::||||||::::|||::||.
Yeast  1297 YPVEKLPDDYVAVKVPQFSFPRLAGADPVLGVEMASTGEVATFGHSKYEAYLKSLLATGFKLPKK 1361

  Fly  1328 AVLLSIGSFKHKMELLPSIRDLAKMGYKLYASMGTGDFYAEHGVNVESVQWTFDKTTPDDINGEL 1392
            .:||||||:|.|.|||.|::.|..|||||:|:.||.||.:|||:   :||:.......||.....
Yeast  1362 NILLSIGSYKEKQELLSSVQKLYNMGYKLFATSGTADFLSEHGI---AVQYLEVLNKDDDDQKSE 1423

  Fly  1393 RHLAEFLANKQFDLVINLPMSGGGARRVSSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMRM 1457
            ..|.:.|||.:.||.|||| |....||.:|:::.||:|||||||||:||||:|||.|||:|::..
Yeast  1424 YSLTQHLANNEIDLYINLP-SANRFRRPASYVSKGYKTRRLAVDYSVPLVTNVKCAKLLIEAISR 1487

  Fly  1458 NGGKPPMKTHTDCMTSRRIVKLPGFIDVHVHLREPGATH----KEDFASGTAAALAGGVTLVCAM 1518
            |....  .:..|..||.|.:.|||.|::..::  |.|:|    ..:....|...|..|.|....|
Yeast  1488 NITLD--VSERDAQTSHRTITLPGLINIATYV--PNASHVIKGPAELKETTRLFLESGFTYCQLM 1548

  Fly  1519 PN--TNPSIVDRETFTQFQELAKAGARCDYALYVGASDDNWAQVNELASHACGLKMYLNDTFGTL 1581
            |.  :.|.|.|..:......:::..:..|::..:..:..|...|.:.||....|.:.|.:    |
Yeast  1549 PRSISGPVITDVASLKAANSVSQDSSYTDFSFTIAGTAHNAHSVTQSASKVTALFLPLRE----L 1609

  Fly  1582 KLSDMTSWQRHLSHWPKRSPIVCHAERQSTAAVIMLAHLLDRSVHICHVARKEEIQLIRSAKEKG 1646
            | :.:|:....|:.||....::..|:....|:|::|..|.:||:||..|:.||::.||.:.|.|.
Yeast  1610 K-NKITAVAELLNQWPTEKQVIAEAKTADLASVLLLTSLQNRSIHITGVSNKEDLALIMTVKAKD 1673

  Fly  1647 VKVTCEVCPHHLFLSTKDVERLGHGMSEVRPLLCSPEDQEALWENIDYIDVFATDHAPHTLAEKR 1711
            .:|||:|..:.||::..|...        ...|.:.||||..|.|:|.||.|:....|..||...
Yeast  1674 PRVTCDVNIYSLFIAQDDYPE--------AVFLPTKEDQEFFWNNLDSIDAFSVGALPVALANVT 1730

  Fly  1712 SERPPPGFPGVETILPLLLQAVHEGRLTMEDIKRKFHRNPKIIFNLPDQAQTYVEVDLDEEWTIT 1776
            ..:...|. |::..|||||.||.||:||::||..:.|.||..|||:|.| .:.||:|||..:
Yeast  1731 GNKVDVGM-GIKDSLPLLLAAVEEGKLTIDDIVLRLHDNPAKIFNIPTQ-DSVVEIDLDYSF--- 1790

  Fly  1777 GNEMKSKSGWTPFEGTKVKGRVHRVVLRGEVAFVDGQVLVQPGFGQNVRPKQSPLASEASQDLLP 1841
                :....|:|| ...:.|.:.|||..||...:.|: ||.||.........||.:..||.:|
Yeast  1791 ----RRNKRWSPF-NKDMNGGIERVVYNGETLVLSGE-LVSPGAKGKCIVNPSPASITASAEL-- 1847

  Fly  1842 SDNDANDTFTRLLTSEGPGGGVHGISTKVHFVDGANFLRPNSPSPRIRLDSASNTTLREY----- 1901
            ....|...|:  :|.|.....          :|.|....|..|   :.....|:...||.
Yeast  1848 QSTSAKRRFS--ITEEAIADN----------LDAAEDAIPEQP---LEQKLMSSRPPRELVAPGA 1897

  Fly  1902 LQRTTNSNPVAHSLMGKHILAVDMFNKDHLNDIFNLAQLLKLRGTKDRPVDELLPGKIMASVFYE 1966
            :|....||   :...|:|||::..|.:...:.:|.:||.|:....::..:| |:.|.::.::|:|
Yeast  1898 IQNLIRSN---NPFRGRHILSIKQFKRSDFHVLFAVAQELRAAVAREGVLD-LMKGHVITTIFFE 1958

  Fly  1967 VSTRTQCSFAAAMLRLGGRVISMDNITSSVKKGESLEDSIKVVSSYADVVVLRHPSPGAVARAAT 2031
            .||||..||.|||.|||||:::::.:.|||||||:|:|:|:.::.|:|.:|:||....:|..||.
Yeast  1959 PSTRTCSSFIAAMERLGGRIVNVNPLVSSVKKGETLQDTIRTLACYSDAIVMRHSEEMSVHIAAK 2023

  Fly  2032 FSRKPLINAGDGVGEHPTQALLDIFTIREEFGTVNGLTITMVGDLKNGRTVHSLARLLTLYNVNL 2096
            :|..|:||.|:|..||||||.||:||||||.|||||:|:|.:||||:|||||||.|||..|.|.:
Yeast  2024 YSPVPIINGGNGSREHPTQAFLDLFTIREEIGTVNGITVTFMGDLKHGRTVHSLCRLLMHYQVRI 2088

  Fly  2097 QYVAPNSLQMPDEVVQFVHQRGVKQLFARDL-KNVLPDTDVLYMTRIQRERFDNVEDYEKCCGHL 2160
            ..|:|..|::|:.:.:.:.:.|:..:.:.:| .:::..|||||.||:|.|||::.|:|.:.....
Yeast  2089 NLVSPPELRLPEGLREELRKAGLLGVESIELTPHIISKTDVLYCTRVQEERFNSPEEYARLKDTY 2153

  Fly  2161 VLTPEHMMRAKKRSIVLHPLPRLNEISREIDSDPRAAYFRQAEYGMYIRMALLAMVVG 2218
            ::..:.:..||:...::|||||:|||..|:|.|.|||||||.:||:::||||||||:|
Yeast  2154 IVDNKILAHAKENMAIMHPLPRVNEIKEEVDYDHRAAYFRQMKYGLFVRMALLAMVMG 2211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_001285343.1	CPSaseIIsmall	7..376	CDD:273580	188/393 (48%)
		CPSase_sm_chain	7..151	CDD:279346	70/145 (48%)
		GATase1_CPSase	196..371	CDD:153215	99/174 (57%)
		CPSaseII_lrg	403..1455	CDD:273581	645/1062 (61%)
		CPSase_L_D2	524..726	CDD:280881	143/201 (71%)
		CPSase_L_D3	815..935	CDD:280882	54/122 (44%)
		P-loop_NTPase	947..>1149	CDD:304359	135/201 (67%)
		ATP-grasp_4	1084..1265	CDD:302634	108/180 (60%)
		MGS_CPS_I_III	1327..1453	CDD:238711	65/125 (52%)
		CAD_DHOase	1475..1821	CDD:238641	109/351 (31%)
		PLN02527	1918..2220	CDD:178142	138/302 (46%)
		OTCace_N	1919..2060	CDD:280825	62/140 (44%)
		OTCace	2067..2216	CDD:278609	66/149 (44%)
URA2	NP_012405.2	CPSaseIIsmall	23..409	CDD:273580	188/393 (48%)
		CPSaseII_lrg	439..1485	CDD:273581	645/1061 (61%)
		metallo-dependent_hydrolases	1503..1830	CDD:412281	109/352 (31%)
		PyrB	1904..2212	CDD:223614	141/312 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I235
eggNOG	1	0.900	-	-		E1_COG0458
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1412
Inparanoid	1	1.050	2018	1.000	Inparanoid score	I2
Isobase	1	0.950	-	0	Normalized mean entropy	S533
OMA	1	1.010	-	-		QHG55291
OrthoFinder	1	1.000	-	-		FOG0001016
OrthoInspector	1	1.000	-	-		oto100381
orthoMCL	1	0.900	-	-		OOG6_100435
Panther	1	1.100	-	-	O	PTHR11405
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1046
SonicParanoid	1	1.000	-	-		X1225
TreeFam	1	0.960	-	-
	15	14.810