DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment r and CARB

DIOPT Version :9

Sequence 1:	NP_001285343.1	Gene:	r / 32640	FlyBaseID:	FBgn0003189	Length:	2224	Species:	Drosophila melanogaster
Sequence 2:	NP_564338.1	Gene:	CARB / 839868	AraportID:	AT1G29900	Length:	1187	Species:	Arabidopsis thaliana

Alignment Length:	1167	Identity:	454/1167 - (38%)
Similarity:	660/1167 - (56%)	Gaps:	91/1167 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 FDVFMESIQQK-DLT-----IPQLIEQRLRPTTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYS 425
            |..|...:.:| .||     :.:|.:...:|.:|.|.......:|::|||:|.:.||||.|||||
plant    56 FSTFPPCLNRKSSLTHVLKPVSELADTTTKPFSPEIVGKRTDLKKIMILGAGPIVIGQACEFDYS 120

  Fly   426 GSQAIKAMRESNIQTVLINPNIATVQTSKGMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQT 490
            |:||.||:||...:.:|||.|.||:.|....|::.|..|:||..|||||:.|||:.:|.|.||||
plant   121 GTQACKALREEGYEVILINSNPATIMTDPETANRTYIAPMTPELVEQVIEKERPDALLPTMGGQT 185

  Fly   491 ALNCGVQLERAGVFSKYNVRILGTPIQSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAA 555
            |||..|.|..:|...||.|.::|..:.:|.:.|||:||.:.:..||.:..||....::.:..|.|
plant   186 ALNLAVALAESGALEKYGVELIGAKLGAIKKAEDRELFKDAMKNIGLKTPPSGIGTTLDECFDIA 250

  Fly   556 SRLG-YPVMARAAFSLGGLGSGFANNEEELQSLAQQALAHS--SQLIVDKSLKGWKEVEYEVVRD 617
            .::| :|::.|.||:|||.|.|.|.|:||.:|:.:..||.|  ||::|:|||.||||.|.||:||
plant   251 EKIGEFPLIIRPAFTLGGTGGGIAYNKEEFESICKSGLAASATSQVLVEKSLLGWKEYELEVMRD 315

  Fly   618 AYNNCITVCNMENFDPLGIHTGESIVVAPSQTLSDREYQMLRSTALKVIRHFGVVGEC---NIQY 679
            ..:|.:.:|::||.||:|:|||:||.|||:|||:|||||.||..::.:||..||  ||   |:|:
plant   316 LADNVVIICSIENIDPMGVHTGDSITVAPAQTLTDREYQRLRDYSIAIIREIGV--ECGGSNVQF 378

  Fly   680 ALCPHSEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGLPLPDIKNSVTGNTTACFEPSL 744
            |:.|...:..|||:|.|:||||||||||||:|:|.:||||::|..|..|.|.:|..|.|.||||:
plant   379 AVNPVDGEVMIIEMNPRVSRSSALASKATGFPIAKMAAKLSVGYTLDQIPNDITRKTPASFEPSI 443

  Fly   745 DYCVVKIPRWDLAKFVRVSKHIGSSMKSVGEVMAIGRNFEEAFQKALRMVDSDVLGF-------- 801
            ||.|.||||:...||......:.:.||||||.||:||.|:|:||||||.::....|:
plant   444 DYVVTKIPRFAFEKFPGSQPLLTTQMKSVGESMALGRTFQESFQKALRSLECGFSGWGCAKIKEL 508

  Fly   802 DPDVVPLNKEQLAEQLSEPTDRRPFVIAAALQLGMSLRELHQLTNIDYWFLEKLERII-LLQSLL 865
            |.|     .:||...|..|...|...|.||::.||.:.|:::|:.:|.|||.:|:.:: :.|.|:
plant   509 DWD-----WDQLKYSLRVPNPDRIHAIYAAMKKGMKIDEIYELSMVDKWFLTQLKELVDVEQYLM 568

  Fly   866 TRNGSRTDAALLLKAKRFGFSDKQIAKYIKSTELAVRHQRQEFGIRPHVKQIDTVAGEWPASTNY 930
            :...|......|.:.|:.||||||||...|:||..||.:|...|:.|..|::||.|.|:.|.|.|
plant   569 SGTLSEITKEDLYEVKKRGFSDKQIAFATKTTEEEVRTKRISLGVVPSYKRVDTCAAEFEAHTPY 633

  Fly   931 LYHTYNGSEHDVDFPGG-----HTIVVGSGVYRIGSSVEFDWCAVGCLRELRKLQRPTIMINYNP 990
            :|.:|     ||:....     ..:::|.|..|||..:|||:|.......|:.....|||:|.||
plant   634 MYSSY-----DVECESAPNNKKKVLILGGGPNRIGQGIEFDYCCCHTSFALQDAGYETIMLNSNP 693

  Fly   991 ETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILSMGGQLPNNIA------MDLHRQQA--- 1046
            ||||||||..||||||.::.|.|:::.::|..:|||:..|||.|..:|      :|.|...:
plant   694 ETVSTDYDTSDRLYFEPLTIEDVLNVIDLEKPDGIIVQFGGQTPLKLALPIKHYLDKHMPMSLSG 758

  Fly  1047 ----KVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCEEVGYPCLVRPSYVL 1107
                ::.||||:|||.||:|.:|:.:||...|.||:.....:...|:...:|||||.:|||||||
plant   759 AGPVRIWGTSPDSIDAAEDRERFNAILDELKIEQPKGGIAKSEADALAIAKEVGYPVVVRPSYVL 823

  Fly  1108 SGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVA-SDGRILCMAVSEHVEN 1171
            .|.||.:.|.:..|.|||..|.:|..|.||::.|:|::|.|||||.:. |.|.::...:.||:|.
plant   824 GGRAMEIVYDDSRLITYLENAVQVDPERPVLVDKYLSDAIEIDVDTLTDSYGNVVIGGIMEHIEQ 888

  Fly  1172 AGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQ-LIAKNNELKVIECNVRVSR 1235
            |||||||:..:.|.|.:.|..|:.|:..|..||..|:|.|..|.| .|..:.::.::|.|.|.||
plant   889 AGVHSGDSACMLPTQTIPASCLQTIRTWTTKLAKKLNVCGLMNCQYAITTSGDVFLLEANPRASR 953

  Fly  1236 SFPFVSKTLDHDFVATATRAIVGLDVEPLDVLHGV--GKVGVKVPQFSFSRLAGADVQLGVEMAS 1298
            :.|||||.:.|.....|...:.|..::.|:....|  ..|.||...|.|.:..|.||.||.||.|
plant   954 TVPFVSKAIGHPLAKYAALVMSGKSLKDLNFEKEVIPKHVSVKEAVFPFEKFQGCDVILGPEMRS 1018

  Fly  1299 TGEVACFGDNRYEAYLKAMMSTGFQIP-KNAVLLSIGSFKHKMELLPSIRDLA----KMGYKLYA 1358
            ||||.........|:..|.::.|.::| ...|.||:.....     |.:..:|    ::|:|:.|
plant  1019 TGEVMSISSEFSSAFAMAQIAAGQKLPLSGTVFLSLNDMTK-----PHLEKIAVSFLELGFKIVA 1078

  Fly  1359 SMGTGDFYAEHGVNVESVQWTFDKTTPDDINGELRHLAEFLANKQFDLVINLPMSGGGARRVSSF 1423
            :.||..|....|:.||.|.         .::....|.|:.:||.|..|:  |..|.|.|..
plant  1079 TSGTAHFLELKGIPVERVL---------KLHEGRPHAADMVANGQIHLM--LITSSGDALD---- 1128

  Fly  1424 MTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMRMNGGKPPMKTHTDCMTSRRIVKLPGFIDV 1485
            ...|.:.|::|:.|.:|::|.|.......|.::      .:|:....||:     |..|.:|
plant  1129 QKDGRQLRQMALAYKVPVITTVAGALATAEGIK------SLKSSAIKMTA-----LQDFFEV 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_001285343.1	CPSaseIIsmall	7..376	CDD:273580	2/8 (25%)
		CPSase_sm_chain	7..151	CDD:279346
		GATase1_CPSase	196..371	CDD:153215	1/3 (33%)
		CPSaseII_lrg	403..1455	CDD:273581	439/1093 (40%)
		CPSase_L_D2	524..726	CDD:280881	102/207 (49%)
		CPSase_L_D3	815..935	CDD:280882	45/120 (38%)
		P-loop_NTPase	947..>1149	CDD:304359	88/219 (40%)
		ATP-grasp_4	1084..1265	CDD:302634	73/182 (40%)
		MGS_CPS_I_III	1327..1453	CDD:238711	32/129 (25%)
		CAD_DHOase	1475..1821	CDD:238641	3/11 (27%)
		PLN02527	1918..2220	CDD:178142
		OTCace_N	1919..2060	CDD:280825
		OTCace	2067..2216	CDD:278609
CARB	NP_564338.1	PLN02735	77..1177	CDD:215391	447/1142 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	198	1.000	Domainoid score	I890
eggNOG	1	0.900	-	-		E1_COG0458
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55291
OrthoDB	1	1.010	-	-		D273358at2759
OrthoFinder	1	1.000	-	-		FOG0001016
OrthoInspector	1	1.000	-	-		oto3258
orthoMCL	1	0.900	-	-		OOG6_100435
Panther	1	1.100	-	-	O	PTHR11405
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1225
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.830