DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment r and CARA

DIOPT Version :9

Sequence 1:	NP_001285343.1	Gene:	r / 32640	FlyBaseID:	FBgn0003189	Length:	2224	Species:	Drosophila melanogaster
Sequence 2:	NP_566824.1	Gene:	CARA / 822396	AraportID:	AT3G27740	Length:	430	Species:	Arabidopsis thaliana

Alignment Length:	391	Identity:	140/391 - (35%)
Similarity:	210/391 - (53%)	Gaps:	37/391 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 STDCYLALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPL 67
            |.:..|.||||::.|..||| .|....:      |:||.|.:.||.|.|||.||:||.:::|.|.
plant    55 SYNARLVLEDGSIWPAKSFG-APGTRIA------ELVFNTSLTGYQEILTDPSYAGQFVLMTNPQ 112

  Fly    68 IGNYGVPAPDEDEHGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQDI 132
            |||.|| .||::|          .|....|.||:..::....:||..|||.|:|.:..:.|:.|:
plant   113 IGNTGV-NPDDEE----------SGQCFLTGLVIRNLSISTSNWRCTKTLADYLTERDIMGVYDL 166

  Fly   133 DTRALTKKLREQGSMLGKIVYE--KPPVEGLPKSSFVDPNVRNLAKECSVKERQVY--------- 186
            ||||:|::|||.||::|.:..|  |...|.|..|...|....:|..:.|.|....:
plant   167 DTRAITRRLREDGSLIGVLSTEQSKTDDELLQMSRSWDIVGIDLISDVSCKSPYEWVDKTNAEWD 231

  Fly   187 ---GNPNGKGPRIAILDCGLKLNQLRCLLQRGASVTLLPW---SARLEDEQFDALFLSNGPGNPE 245
               .:.:||..::...|.|:|.|.||.|...|..:|::|.   :|.......|.:..|||||:|.
plant   232 FNTNSRDGKSYKVIAYDFGIKQNILRRLSSYGCQITVVPSTFPAAEALKMNPDGILFSNGPGDPS 296

  Fly   246 SCDQIVQQVRKVIEEGQKPVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQ 310
            :....|:.|::::  |:.||:|||:|||||.:|:|..|:|||:|:.|.|.|..:..||:..:::|
plant   297 AVPYAVETVKELL--GKVPVYGICMGHQLLGQALGGKTFKMKFGHHGGNHPVRNNRTGQVEISAQ 359

  Fly   311 NHGYAVDLEQLPDGWSELFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQ 375
            ||.||||...||.|.....||.|||:..|:........|:|:|||...||.|::..|..|:|.::
plant   360 NHNYAVDPASLPGGVEVTHVNLNDGSCAGLSFPEMNVMSLQYHPEASPGPHDSDNAFREFIELMK 424

  Fly   376 Q 376
            :
plant   425 R 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_001285343.1	CPSaseIIsmall	7..376	CDD:273580	139/385 (36%)
		CPSase_sm_chain	7..151	CDD:279346	58/143 (41%)
		GATase1_CPSase	196..371	CDD:153215	68/177 (38%)
		CPSaseII_lrg	403..1455	CDD:273581
		CPSase_L_D2	524..726	CDD:280881
		CPSase_L_D3	815..935	CDD:280882
		P-loop_NTPase	947..>1149	CDD:304359
		ATP-grasp_4	1084..1265	CDD:302634
		MGS_CPS_I_III	1327..1453	CDD:238711
		CAD_DHOase	1475..1821	CDD:238641
		PLN02527	1918..2220	CDD:178142
		OTCace_N	1919..2060	CDD:280825
		OTCace	2067..2216	CDD:278609
CARA	NP_566824.1	PLN02771	1..416	CDD:178370	137/380 (36%)
		CPSase_sm_chain	58..185	CDD:279346	58/144 (40%)
		GATase1_CPSase	244..420	CDD:153215	68/177 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	131	1.000	Domainoid score	I1675
eggNOG	1	0.900	-	-		E1_COG0458
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810