DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment r and CAD

DIOPT Version :9

Sequence 1:	NP_001285343.1	Gene:	r / 32640	FlyBaseID:	FBgn0003189	Length:	2224	Species:	Drosophila melanogaster
Sequence 2:	NP_004332.2	Gene:	CAD / 790	HGNCID:	1424	Length:	2225	Species:	Homo sapiens

Alignment Length:	2269	Identity:	1430/2269 - (63%)
Similarity:	1707/2269 - (75%)	Gaps:	107/2269 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNYG 72
            |.||||:||.|..||       :.|...||||||||||||.|||||.||..||||||||||||||
Human     4 LVLEDGSVLRGQPFG-------AAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYG 61

  Fly    73 VPAPDEDEHGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQDIDTRAL 137
            :|..:.||.||...||  ...:...||||||......||...:||.:||:||.:||:|.:|||.|
Human    62 IPPDEMDEFGLCKWFE--SSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDTREL 124

  Fly   138 TKKLREQGSMLGKIVYEKPPVEGLPKSSFVDPNVRNLAKECSVKERQVYGNPNGKGPRIAILDCG 202
            |||||||||:|||:|........||   |:|||.|.|..|.|:|..:|:.  .|..|||..||||
Human   125 TKKLREQGSLLGKLVQNGTEPSSLP---FLDPNARPLVPEVSIKTPRVFN--TGGAPRILALDCG 184

  Fly   203 LKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGPGNPESCDQIVQQVRKVIEE-GQKPVF 266
            ||.||:|||.||||.||::||...|:.::::.||||||||:|.|...:|..:.:|:.| ..:|||
Human   185 LKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLSEPNPRPVF 249

  Fly   267 GICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDLEQLPDGWSELFVN 331
            ||||||||||.|||..||||:|||||||.|||...:|||.:||||||:||:.:.||..|:.||.|
Human   250 GICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVETDSLPADWAPLFTN 314

  Fly   332 ANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQQKDLTIP--QLIEQRLR---- 390
            ||||:||||||.|.|:|||||||||.|||.|.|.|||:|:|::::.....|  |.:.:||.
Human   315 ANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEATAGNPGGQTVRERLTERLC 379

  Fly   391 -PTTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIATVQTSK 454
             |..|...|....||||||||||||||||||||||||||||||::|.||||:||||||||||||:
Human   380 PPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQ 444

  Fly   455 GMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVQLERAGVFSKYNVRILGTPIQSI 519
            |:|||.||||:|||||.|||::|||:||||||||||||||||:|.:|||.::|.||:||||:::|
Human   445 GLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETI 509

  Fly   520 IETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYPVMARAAFSLGGLGSGFANNEEEL 584
            ..||||:.||.|:.||||.||||||..|:.||..||.||||||:.||||:|||||||||:|.|||
Human   510 ELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREEL 574

  Fly   585 QSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCITVCNMENFDPLGIHTGESIVVAPSQT 649
            .:|...|.||:||::||||||||||:|||||||||.||:|||||||.||||||||||||||||||
Human   575 SALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQT 639

  Fly   650 LSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKATGYPLAY 714
            |:|||||:||.||:||.:|.|:|||||:||||.|.||||||||||||||||||||||||||||||
Human   640 LNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAY 704

  Fly   715 VAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSVGEVMAI 779
            ||||||||:|||:::|||||. ||.||||:||||||||||||:||:|||..|||.||||||||.|
Human   705 VAAKLALGIPLPELRNSVTGG-TAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGI 768

  Fly   780 GRNFEEAFQKALRMVDSDVLGFDPDVVPLNKEQLAEQLSEPTDRRPFVIAAALQLGMSLRELHQL 844
            ||:|||||||||||||.:.:|||..|.|::.    .:|..|||:|.||:||||..|.|:..|::|
Human   769 GRSFEEAFQKALRMVDENCVGFDHTVKPVSD----MELETPTDKRIFVVAAALWAGYSVDRLYEL 829

  Fly   845 TNIDYWFLEKLERIILLQSLLTRN-GSRTDAALLLKAKRFGFSDKQIAKYIKSTELAVRHQRQEF 908
            |.||.|||.:::|||....||.:: |......||.:||..||||||||..:.|||||||..|||.
Human   830 TRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQEL 894

  Fly   909 GIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDFPGGHTIVVGSGVYRIGSSVEFDWCAVGCL 973
            ||.|.||||||||.||||.|||||.||.|:.||:.|...|.:|:||||||||||||||||||||:
Human   895 GICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCI 959

  Fly   974 RELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILSMGGQLPNNIA 1038
            ::|||:...|||:|||||||||||||||||||:||||||||||||:||.||:|||||||||||:|
Human   960 QQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMA 1024

  Fly  1039 MDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCEEVGYPCLVRP 1103
            |.|||||.:|||||||:||.|||||||||:||..||.||:|:||::|:||.:||:.|||||:|||
Human  1025 MALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRP 1089

  Fly  1104 SYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVASDGRILCMAVSEH 1168
            |||||||||||||::.|||.:|::|:.||:|||||||||:.||||||||||||||.:..:|:|||
Human  1090 SYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEH 1154

  Fly  1169 VENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAKNNELKVIECNVRV 1233
            |||||||||||||||||||:.|:|||.||.|...:...|.||||||:|||||:::||||||||||
Human  1155 VENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRV 1219

  Fly  1234 SRSFPFVSKTLDHDFVATATRAIVGLDVEPLDVLHGVGKVGVKVPQFSFSRLAGADVQLGVEMAS 1298
            |||||||||||..|.||.|||.|:|.:|||:.::.|.|.||||||||||||||||||.|||||.|
Human  1220 SRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKVPQFSFSRLAGADVVLGVEMTS 1284

  Fly  1299 TGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSIGSFKHKMELLPSIRDLAKMGYKLYASMGTG 1363
            |||||.||::|.|||||||:||||:|||..:||:|||:|:|.||||::|.|..:||.||||:||.
Human  1285 TGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTA 1349

  Fly  1364 DFYAEHGVNVESVQWTFDKTTPDDINGEL---RHLAEFLANKQFDLVINLPMSGGGARRVSSFMT 1425
            |||.||||.|.:|.|.|::.    ::||.   |.:.|.||.|.|:|||||.|.|.|.||:|||:|
Human  1350 DFYTEHGVKVTAVDWHFEEA----VDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVT 1410

  Fly  1426 HGYRTRRLAVDYSIPLVTDVKCTKLLVESMRMNGGKPPMKTHTDCMTSRRIVKLPGFIDVHVHLR 1490
            .||||||||.|:|:||:.|:|||||.||::...|..||:|.|.|||||:::|:|||.||||||||
Human  1411 KGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLR 1475

  Fly  1491 EPGATHKEDFASGTAAALAGGVTLVCAMPNTNPSIVDRETFTQFQELAKAGARCDYALYVGASDD 1555
            |||.|||||||||||||||||:|:|||||||.|.|:|.......|:||:||||||:||::|||.:
Human  1476 EPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSE 1540

  Fly  1556 NWAQVNELASHACGLKMYLNDTFGTLKLSDMTSWQRHLSHWPKRSPIVCHAERQSTAAVIMLAHL 1620
            |...:..:|..|.|||:|||:||..|:|..:..|..|...||...|||.|||:|:.|||:|:|.|
Human  1541 NAGTLGTVAGSAAGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQL 1605

  Fly  1621 LDRSVHICHVARKEEIQLIRSAKEKGVKVTCEVCPHHLFLSTKDVERLGHGMSEVRPLLCSPEDQ 1685
            ..||||||||||||||.||::||.:|:.|||||.|||||||..|:||||.|..||||.|.|.:|.
Human  1606 TQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDV 1670

  Fly  1686 EALWENIDYIDVFATDHAPHTLAEKRSERPPPGFPGVETILPLLLQAVHEGRLTMEDIKRKFHRN 1750
            ||||||:..||.||:|||||||.||...||||||||:||:|||||.||.||||:::|:.::.|.|
Human  1671 EALWENMAVIDCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHN 1735

  Fly  1751 PKIIFNLPDQAQTYVEVDLDEEWTITGNEMKSKSGWTPFEGTKVKGRVHRVVLRGEVAFVDGQVL 1815
            |:.||:||.|..|||||||:.||||..:...||:.||||||.||||.|.|||||||||::|||||
Human  1736 PRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVL 1800

  Fly  1816 VQPGFGQNVR----------PKQSPLASEASQDLLPSDNDANDTFTRLLTSEGPGGGVHGISTKV 1870
            |.||:||:||          |..:|..||.:                 .|.|.|..|:.|:.
Human  1801 VPPGYGQDVRKWPQGAVPQLPPSAPATSEMT-----------------TTPERPRRGIPGLP--- 1845

  Fly  1871 HFVDGANFLRPN------------------------------------SPSPRIRLDSASNTTLR 1899
               ||...|.|.                                    .|.|..|..|..|....
Human  1846 ---DGRFHLPPRIHRASDPGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTP 1907

  Fly  1900 EYLQRTTNSNPVAHSLMGKHILAVDMFNKDHLNDIFNLAQLLKLRGTKDRPVDELLPGKIMASVF 1964
            ..|...|  :|:.|||:|:|||:|..|.||.::.:||:|..|::...|:|.:| :|.||:|||:|
Human  1908 GLLHPQT--SPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLD-ILKGKVMASMF 1969

  Fly  1965 YEVSTRTQCSFAAAMLRLGGRVISMDNITSSVKKGESLEDSIKVVSSYADVVVLRHPSPGAVARA 2029
            |||||||..||||||.||||.|:|....||||:|||||.||::.:|.||||||||||.||||..|
Human  1970 YEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELA 2034

  Fly  2030 ATFSRKPLINAGDGVGEHPTQALLDIFTIREEFGTVNGLTITMVGDLKNGRTVHSLARLLTLYNV 2094
            |...|:|:||||||||||||||||||||||||.|||||:|||||||||:||||||||.|||.|.|
Human  2035 AKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRV 2099

  Fly  2095 NLQYVAPNSLQMPDEVVQFVHQRGVKQLFARDLKNVLPDTDVLYMTRIQRERFDNVEDYEKCCGH 2159
            :|:||||.||:||..|..||..||.||.....::..|||||||||||||:|||.:.::||.|.|.
Human  2100 SLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEACFGQ 2164

  Fly  2160 LVLTPEHMMRAKKRSIVLHPLPRLNEISREIDSDPRAAYFRQAEYGMYIRMALLAMVVG 2218
            .:|||..|.||||:.:|:||:||:||||.|:|||||||||||||.||||||||||.|:|
Human  2165 FILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLG 2223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_001285343.1	CPSaseIIsmall	7..376	CDD:273580	212/368 (58%)
		CPSase_sm_chain	7..151	CDD:279346	83/142 (58%)
		GATase1_CPSase	196..371	CDD:153215	110/175 (63%)
		CPSaseII_lrg	403..1455	CDD:273581	751/1055 (71%)
		CPSase_L_D2	524..726	CDD:280881	158/201 (79%)
		CPSase_L_D3	815..935	CDD:280882	69/120 (58%)
		P-loop_NTPase	947..>1149	CDD:304359	153/201 (76%)
		ATP-grasp_4	1084..1265	CDD:302634	130/180 (72%)
		MGS_CPS_I_III	1327..1453	CDD:238711	72/128 (56%)
		CAD_DHOase	1475..1821	CDD:238641	221/345 (64%)
		PLN02527	1918..2220	CDD:178142	200/301 (66%)
		OTCace_N	1919..2060	CDD:280825	91/140 (65%)
		OTCace	2067..2216	CDD:278609	100/148 (68%)
CAD	NP_004332.2	PRK12564	1..355	CDD:237139	211/364 (58%)
		GATase (Glutamine amidotransferase). /evidence=ECO:0000250\|UniProtKB:P08955	2..365		212/374 (57%)
		CPSase_sm_chain	2..138	CDD:279346	83/142 (58%)
		GATase1_CPSase	178..354	CDD:153215	110/175 (63%)
		Linker. /evidence=ECO:0000250\|UniProtKB:P08955	366..394		6/27 (22%)
		CPSaseII_lrg	391..1440	CDD:273581	751/1057 (71%)
		CPSase (Carbamoyl-phosphate synthase). /evidence=ECO:0000250\|UniProtKB:P08955	395..1455		754/1068 (71%)
		CPSase A. /evidence=ECO:0000250\|UniProtKB:P08955	395..933		389/542 (72%)
		CPSase_L_D2	514..716	CDD:280881	158/201 (79%)
		CPSase_L_D3	801..921	CDD:280882	69/119 (58%)
		CPSase B. /evidence=ECO:0000250\|UniProtKB:P08955	934..1455		365/524 (70%)
		ATP-grasp_4	1048..1245	CDD:302634	141/196 (72%)
		MGS_CPS_I_III	1313..1438	CDD:238711	72/128 (56%)
		PRK09060	1429..1810	CDD:181632	241/380 (63%)
		DHOase (dihydroorotase). /evidence=ECO:0000250\|UniProtKB:P08955	1456..1788		209/331 (63%)
		CAD_DHOase	1460..1806	CDD:238641	221/345 (64%)
		Linker. /evidence=ECO:0000250\|UniProtKB:P08955	1789..1917		37/152 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1811..1899		16/110 (15%)
		ATCase (Aspartate transcarbamylase). /evidence=ECO:0000250\|UniProtKB:P08955	1918..2225		204/307 (66%)
		pyrB	1920..2224	CDD:234849	203/305 (67%)
		OTCace_N	1925..2065	CDD:280825	91/140 (65%)
		OTCace	2072..2221	CDD:278609	100/148 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155681
Domainoid	1	1.000	375	1.000	Domainoid score	I875
eggNOG	1	0.900	-	-		E1_COG0458
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1412
Inparanoid	1	1.050	2740	1.000	Inparanoid score	I25
Isobase	1	0.950	-	0	Normalized mean entropy	S533
OMA	1	1.010	-	-		QHG55291
OrthoDB	1	1.010	-	-		D15670at33208
OrthoFinder	1	1.000	-	-		FOG0001016
OrthoInspector	1	1.000	-	-		oto91821
orthoMCL	1	0.900	-	-		OOG6_100435
Panther	1	1.100	-	-	LDO	PTHR11405
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1046
SonicParanoid	1	1.000	-	-		X1225
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750