DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment r and Cad

DIOPT Version :9

Sequence 1:NP_001285343.1 Gene:r / 32640 FlyBaseID:FBgn0003189 Length:2224 Species:Drosophila melanogaster
Sequence 2:XP_006504154.1 Gene:Cad / 69719 MGIID:1916969 Length:2321 Species:Mus musculus


Alignment Length:2272 Identity:1424/2272 - (62%)
Similarity:1710/2272 - (75%) Gaps:96/2272 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNYG 72
            |.||||:||.|..||       :.|...||||||||||||.|||||.||..||||||||||||||
Mouse    83 LVLEDGSVLQGRPFG-------AAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYG 140

  Fly    73 VPAPDEDEHGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQDIDTRAL 137
            :|:.:|||.||...||  ...:....|||||......||....||.:||:|..:||:|.:|||.|
Mouse   141 IPSDEEDEFGLSKWFE--SSEIHVAGLVVGECCPTPSHWSANCTLHEWLQQRGIPGLQGVDTREL 203

  Fly   138 TKKLREQGSMLGKIVYEKPPVEGLPKSSFVDPNVRNLAKECSVKERQVYGNPNGKGPRIAILDCG 202
            |||||||||:|||:|.:......||   |||||.|.||.|.|:|..:|:.  .|..|||..||||
Mouse   204 TKKLREQGSLLGKLVQKGTEPSALP---FVDPNARPLAPEVSIKTPRVFN--AGGAPRICALDCG 263

  Fly   203 LKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGPGNPESCDQIVQQVRKVIEE-GQKPVF 266
            ||.||:|||.|.||.||::||...|:.:::|.||||||||:|.|...:|..:.:|:.| ..:|||
Mouse   264 LKYNQIRCLCQLGAEVTVVPWDHELDSQKYDGLFLSNGPGDPASYPGVVSTLSRVLSEPNPRPVF 328

  Fly   267 GICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDLEQLPDGWSELFVN 331
            ||||||||||.|||..||||:|||||||.|||...||||.:||||||:|||.:.||.||:.||.|
Mouse   329 GICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGTGRCFLTSQNHGFAVDADSLPAGWAPLFTN 393

  Fly   332 ANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQQK------DLTIPQLIEQRL- 389
            |||.:||||||.|.|:|||||||||.|||.|.|.|||||:|::::.      ..|:.:.:.||| 
Mouse   394 ANDCSNEGIVHDSLPFFSVQFHPEHRAGPSDMELLFDVFLETVREAAAGNIGGQTVRERLAQRLC 458

  Fly   390 RPTTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIATVQTSK 454
            .|..|...|....||||||||||||||||||||||||||||||::|.||||:||||||||||||:
Mouse   459 PPELPIPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQ 523

  Fly   455 GMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVQLERAGVFSKYNVRILGTPIQSI 519
            |:|||.||||:|.|||.|||::|||:||||||||||||||||:|.:|||.::|.||:||||:::|
Mouse   524 GLADKVYFLPITLHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETI 588

  Fly   520 IETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYPVMARAAFSLGGLGSGFANNEEEL 584
            ..||||:.||.|:.||||.||||||..|:.||..||.||||||:.||||:|||||||||:.:|||
Mouse   589 ELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASTKEEL 653

  Fly   585 QSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCITVCNMENFDPLGIHTGESIVVAPSQT 649
            .:|...|.||:||:::|||||||||:|||||||||.||:|||||||.||||||||||||||||||
Mouse   654 SALVAPAFAHTSQVLIDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQT 718

  Fly   650 LSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKATGYPLAY 714
            |:|||||:||.||:||.:|.|:|||||:||||.|.||||||||||||||||||||||||||||||
Mouse   719 LNDREYQLLRRTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAY 783

  Fly   715 VAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSVGEVMAI 779
            ||||||||:|||:::|||||. ||.|||||||||||||||||:||:|||..|||.||||||||.|
Mouse   784 VAAKLALGIPLPELRNSVTGG-TAAFEPSLDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGI 847

  Fly   780 GRNFEEAFQKALRMVDSDVLGFDPDVVPLNKEQLAEQLSEPTDRRPFVIAAALQLGMSLRELHQL 844
            ||:|||||||||||||.:.:|||..|.|::.    .:|..|||:|.||:||||..|.|:..|::|
Mouse   848 GRSFEEAFQKALRMVDENCVGFDHTVKPVSD----MELETPTDKRIFVVAAALWAGYSVERLYEL 908

  Fly   845 TNIDYWFLEKLERIILLQSLLTRN-GSRTDAALLLKAKRFGFSDKQIAKYIKSTELAVRHQRQEF 908
            |.||.|||.:::||:....||.:: |......||.:||..||||||||..:.|||||||..|||.
Mouse   909 TRIDCWFLHRMKRIVTHAQLLEQHRGQALPQDLLHQAKCLGFSDKQIALAVLSTELAVRKLRQEL 973

  Fly   909 GIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDFPGGHTIVVGSGVYRIGSSVEFDWCAVGCL 973
            ||.|.||||||||.||||.|||||.||.|:.||:||...|.:|:||||||||||||||||||||:
Mouse   974 GICPAVKQIDTVAAEWPAQTNYLYLTYWGNTHDLDFRAPHVLVLGSGVYRIGSSVEFDWCAVGCI 1038

  Fly   974 RELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILSMGGQLPNNIA 1038
            ::|||:...|||:|||||||||||||||||||:||||||||||||:||.||:|||||||||||:|
Mouse  1039 QQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMA 1103

  Fly  1039 MDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCEEVGYPCLVRP 1103
            |.|||||.:|||||||:||.|||||||||:||..||.||:|:||::|:||.:||..|||||:|||
Mouse  1104 MALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCHTVGYPCVVRP 1168

  Fly  1104 SYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVASDGRILCMAVSEH 1168
            |||||||||||||::.|||.:|::|:.||:|||||||||:.|||||||||||.||.:..:|:|||
Mouse  1169 SYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVACDGIVSAIAISEH 1233

  Fly  1169 VENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAKNNELKVIECNVRV 1233
            |||||||||||||||||||:..:|||.||.|...:...|.||||||:|||||:::||||||||||
Mouse  1234 VENAGVHSGDATLVTPPQDITPKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRV 1298

  Fly  1234 SRSFPFVSKTLDHDFVATATRAIVGLDVEPLDVLHGVGKVGVKVPQFSFSRLAGADVQLGVEMAS 1298
            |||||||||||..|.||.|||.|:|..|||:.::.|.|.||||||||||||||||||.|||||.|
Mouse  1299 SRSFPFVSKTLGVDLVALATRIIMGEKVEPVGLMTGSGVVGVKVPQFSFSRLAGADVVLGVEMTS 1363

  Fly  1299 TGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSIGSFKHKMELLPSIRDLAKMGYKLYASMGTG 1363
            |||||.||::|.|||||||:||||:||:..:||:|||:|:|.||||::|.|..:||.||||:||.
Mouse  1364 TGEVAGFGESRCEAYLKAMLSTGFKIPEKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTA 1428

  Fly  1364 DFYAEHGVNVESVQWTFDKTTPDDINGEL---RHLAEFLANKQFDLVINLPMSGGGARRVSSFMT 1425
            |||.||||.|.:|.|.|::.    ::||.   |.:.:.||...|:|||||.|.|.|.||:|||:|
Mouse  1429 DFYTEHGVKVTAVDWHFEEA----VDGECPPQRSILDQLAENHFELVINLSMRGAGGRRLSSFVT 1489

  Fly  1426 HGYRTRRLAVDYSIPLVTDVKCTKLLVESMRMNGGKPPMKTHTDCMTSRRIVKLPGFIDVHVHLR 1490
            .||||||||.|:|:||:.|:|||||.||::...|..||:|.|.|||||:::|:|||.||||||||
Mouse  1490 KGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLR 1554

  Fly  1491 EPGATHKEDFASGTAAALAGGVTLVCAMPNTNPSIVDRETFTQFQELAKAGARCDYALYVGASDD 1555
            |||.|||||||||||||||||||:|||||||.|.|:|.......|:||:||||||:.|::|||.:
Mouse  1555 EPGGTHKEDFASGTAAALAGGVTMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFTLFLGASSE 1619

  Fly  1556 NWAQVNELASHACGLKMYLNDTFGTLKLSDMTSWQRHLSHWPKRSPIVCHAERQSTAAVIMLAHL 1620
            |...:..:|..|.|||:|||:||..|:|..:..|..|...||...|||.||||||.|||:|:|.|
Mouse  1620 NAGTLGAVAGSAAGLKLYLNETFSELRLDSVAQWMEHFETWPAHLPIVAHAERQSVAAVLMVAQL 1684

  Fly  1621 LDRSVHICHVARKEEIQLIRSAKEKGVKVTCEVCPHHLFLSTKDVERLGHGMSEVRPLLCSPEDQ 1685
            ..|.||||||||||||.||::||.:|:.|||||.||||||:.:|:||||.|..||||.|.|.||.
Mouse  1685 TQRPVHICHVARKEEILLIKTAKAQGLPVTCEVAPHHLFLNREDLERLGPGKGEVRPELGSREDM 1749

  Fly  1686 EALWENIDYIDVFATDHAPHTLAEKRSERPPPGFPGVETILPLLLQAVHEGRLTMEDIKRKFHRN 1750
            ||||||:..||.||:|||||||.||...:|||||||:||:|||||.||.||||:::|:.::.|.|
Mouse  1750 EALWENMAVIDCFASDHAPHTLEEKCGPKPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHN 1814

  Fly  1751 PKIIFNLPDQAQTYVEVDLDEEWTITGNEMKSKSGWTPFEGTKVKGRVHRVVLRGEVAFVDGQVL 1815
            |:.||:||.|..|||||||:.|||:..:...||:.||||||.||||.|.|||||||||::|||||
Mouse  1815 PRRIFHLPLQEDTYVEVDLEHEWTVPSHMPFSKARWTPFEGQKVKGTVRRVVLRGEVAYIDGQVL 1879

  Fly  1816 VQPGFGQNVRPKQSPLASEASQDLLPSDNDANDTFTRLLTSEG---------PGGGVHGISTKVH 1871
            |.||:||:||        :..|.::|....:....|.:.|:..         |.|..| :..::|
Mouse  1880 VPPGYGQDVR--------KWPQGVVPQPPPSTPATTEITTTPERPRRVIPGLPDGRFH-LPPRIH 1935

  Fly  1872 FVDG----ANFLRPNS-----------------------------------PSPRI-RLDSASNT 1896
            ....    |.:|||.:                                   |:|.: |..|..|.
Mouse  1936 RASDPGLPALYLRPGAGISWGSRAWAEEPKEKPPRKVVEPELMGTPDGPCYPAPPVPRQASPQNL 2000

  Fly  1897 TLREYLQRTTNSNPVAHSLMGKHILAVDMFNKDHLNDIFNLAQLLKLRGTKDRPVDELLPGKIMA 1961
            .....|.  ...:|:.|||:|:|||:|..|.||.::.:||:|..|::...|:|.:| :|.||:||
Mouse  2001 GSSGLLH--PQMSPLLHSLVGQHILSVKQFTKDQMSHLFNVAHTLRMMVQKERSLD-ILKGKVMA 2062

  Fly  1962 SVFYEVSTRTQCSFAAAMLRLGGRVISMDNITSSVKKGESLEDSIKVVSSYADVVVLRHPSPGAV 2026
            |:||||||||..||||||.||||.|:|....||||:|||||.||::.:|.||||:|||||.||||
Mouse  2063 SMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVIVLRHPQPGAV 2127

  Fly  2027 ARAATFSRKPLINAGDGVGEHPTQALLDIFTIREEFGTVNGLTITMVGDLKNGRTVHSLARLLTL 2091
            ..||...|:|:||||||||||||||||||||||||.|||||:|||||||||:||||||||.|||.
Mouse  2128 ELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQ 2192

  Fly  2092 YNVNLQYVAPNSLQMPDEVVQFVHQRGVKQLFARDLKNVLPDTDVLYMTRIQRERFDNVEDYEKC 2156
            |.|:|:||||.||:||..|..||..||.||.....::..|||||||||||||:|||.:|::||.|
Mouse  2193 YRVSLRYVAPPSLRMPPSVRDFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSVQEYEAC 2257

  Fly  2157 CGHLVLTPEHMMRAKKRSIVLHPLPRLNEISREIDSDPRAAYFRQAEYGMYIRMALLAMVVG 2218
            .|..:|||..|.||||:.:|:||:||:||||.|:|||||||||||||.||||||||||.|:|
Mouse  2258 FGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLG 2319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rNP_001285343.1 CPSaseIIsmall 7..376 CDD:273580 216/368 (59%)
CPSase_sm_chain 7..151 CDD:279346 82/142 (58%)
GATase1_CPSase 196..371 CDD:153215 113/175 (65%)
CPSaseII_lrg 403..1455 CDD:273581 744/1055 (71%)
CPSase_L_D2 524..726 CDD:280881 156/201 (78%)
CPSase_L_D3 815..935 CDD:280882 68/120 (57%)
P-loop_NTPase 947..>1149 CDD:304359 153/201 (76%)
ATP-grasp_4 1084..1265 CDD:302634 128/180 (71%)
MGS_CPS_I_III 1327..1453 CDD:238711 70/128 (55%)
CAD_DHOase 1475..1821 CDD:238641 220/345 (64%)
PLN02527 1918..2220 CDD:178142 200/301 (66%)
OTCace_N 1919..2060 CDD:280825 90/140 (64%)
OTCace 2067..2216 CDD:278609 101/148 (68%)
CadXP_006504154.1 PRK12564 79..434 CDD:237139 215/364 (59%)
CPSaseII_lrg 470..1519 CDD:273581 744/1057 (70%)
CAD_DHOase 1539..1885 CDD:238641 220/345 (64%)
pyrB 2016..2320 CDD:234849 203/305 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846122
Domainoid 1 1.000 367 1.000 Domainoid score I919
eggNOG 1 0.900 - - E1_COG0458
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1412
Inparanoid 1 1.050 2741 1.000 Inparanoid score I25
Isobase 1 0.950 - 0 Normalized mean entropy S533
OMA 1 1.010 - - QHG55291
OrthoDB 1 1.010 - - D15670at33208
OrthoFinder 1 1.000 - - FOG0001016
OrthoInspector 1 1.000 - - oto95400
orthoMCL 1 0.900 - - OOG6_100435
Panther 1 1.100 - - LDO PTHR11405
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1046
SonicParanoid 1 1.000 - - X1225
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1716.750

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