DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment r and cps1

DIOPT Version :9

Sequence 1:NP_001285343.1 Gene:r / 32640 FlyBaseID:FBgn0003189 Length:2224 Species:Drosophila melanogaster
Sequence 2:XP_683282.4 Gene:cps1 / 555623 ZFINID:ZDB-GENE-081105-17 Length:1508 Species:Danio rerio


Alignment Length:1472 Identity:789/1472 - (53%)
Similarity:1034/1472 - (70%) Gaps:61/1472 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 YLALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNY 71
            :|.|||||.:.|||||:..|.       .||:||.||:|||.|||||.||.||||.||||::|||
Zfish    36 HLVLEDGTKMKGYSFGHDQSA-------AGELVFNTGLVGYPEALTDPSYRGQILTLTYPIVGNY 93

  Fly    72 GVPAPDE-DEHGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQDIDTR 135
            |||...| ||.||..:.|  ...:|.:.|:|.:.:.|..||...|:|..||::.|||.:..||||
Zfish    94 GVPNTQELDELGLKKNVE--SDRIQVSGLLVQDYSAEYSHWNSVKSLAQWLQEEKVPALFGIDTR 156

  Fly   136 ALTKKLREQGSMLGKIVYEKPPVEGLPKSSFVDPNVRNLAKECSVKERQVYGNPNGKGPRIAILD 200
            .|||.:|::|::||||.::..|||      ..|||.|||..|.|.|:.||:|  .|...::..:|
Zfish   157 MLTKIIRDKGTVLGKIEFDGQPVE------ITDPNQRNLVSEVSTKDIQVFG--KGNPVKVVAVD 213

  Fly   201 CGLKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGPGNPESCDQIVQQVRKVIEEGQ-KP 264
            ||:|.|.:|.|::|||.|.|:||...|...::|.||:|||||:|.....::|.||||:|..: :|
Zfish   214 CGIKHNIIRLLVKRGAEVHLVPWDQDLMSLEYDGLFISNGPGDPSLAKTLIQNVRKVLESDRPQP 278

  Fly   265 VFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDLEQLPDGWSELF 329
            |||||:|:|:.|.|.|..:||:..||||.|.|.::..||:..:|:|||||.:|.|.||.|||.||
Zfish   279 VFGICMGNQITALAAGAQSYKLPMGNRGQNQPVVNVMTGQAFITAQNHGYGIDSESLPPGWSPLF 343

  Fly   330 VNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQQ-KDLTIPQLIEQRLRPTT 393
            :||||||||||:|.:||.|:.|||||...||.|||||||.|:..|:: ::.:|..::     |..
Zfish   344 INANDGTNEGIMHNTKPVFTAQFHPEAKGGPTDTEFLFDAFISLIRKGREGSIASVM-----PKK 403

  Fly   394 PAIDSAPVMPR----KVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIATVQTSK 454
            ||     |.||    |||:|||||||||||||||||||||:|||||.|:||||||||||:|||::
Zfish   404 PA-----VPPRIQVSKVLVLGSGGLSIGQAGEFDYSGSQAVKAMREENLQTVLINPNIASVQTNE 463

  Fly   455 ---GMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVQLERAGVFSKYNVRILGTPI 516
               ..||..||||:||.:|.|||..|||:|:||:.||||||||||:|.::||..||.|::||||:
Zfish   464 VGTKQADSVYFLPVTPEFVTQVISVERPDGILLSMGGQTALNCGVELFQSGVLEKYGVKVLGTPV 528

  Fly   517 QSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYPVMARAAFSLGGLGSGFANNE 581
            :||:.||||:||::::.||.|::|||.||.:||.||.||..:|||||.|:|::|||||||...|:
Zfish   529 ESIMATEDRQLFSDKLMEINEKIAPSFAVKTVADALKAADEIGYPVMLRSAYALGGLGSGLCANK 593

  Fly   582 EELQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCITVCNMENFDPLGIHTGESIVVAP 646
            |:|:..|.:|||.|||::|:|||.||||||||||||..:||:||||||||||||||||:||||||
Zfish   594 EKLEDTAHKALAMSSQILVEKSLLGWKEVEYEVVRDIADNCVTVCNMENFDPLGIHTGDSIVVAP 658

  Fly   647 SQTLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKATGYP 711
            |||||:.||.|||.||:||:||.|:||||||||||.|.|.:|.||||||||||||||||||||||
Zfish   659 SQTLSNEEYHMLRETAIKVVRHLGIVGECNIQYALHPSSLEYCIIEVNARLSRSSALASKATGYP 723

  Fly   712 LAYVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSVGEV 776
            ||:||||||||:|||:|||:|:..|||||||||||.|.|||||||.:|..:|:.|||:|||||||
Zfish   724 LAFVAAKLALGIPLPEIKNAVSEQTTACFEPSLDYIVTKIPRWDLDRFHGMSREIGSAMKSVGEV 788

  Fly   777 MAIGRNFEEAFQKALRMVDSDVLGFDPDVVPLNK-----EQLAEQLSEPTDRRPFVIAAALQLGM 836
            ||:||:|||:.||||||....|.||.|. :||.|     :.|..:||.|:..|.|.:|.||..|:
Zfish   789 MAVGRSFEESIQKALRMCHPSVDGFVPR-LPLKKAWAEQQDLQRELSMPSSTRIFSLAQALHSGV 852

  Fly   837 SLRELHQLTNIDYWFLEKLERIILLQSLLTRNGSRT-DAALLLKAKRFGFSDKQIAKYIKSTELA 900
            ::.::|.||.||.|||.||:.|..::..|.:..|.| ...||||||..||||:|:.:.:..:|..
Zfish   853 TVDQIHDLTAIDKWFLHKLKHITEMEQRLGQYKSATVPRDLLLKAKMDGFSDRQVGQAMDISEGE 917

  Fly   901 VRHQRQEFGIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDFPGGHTIVVGSGVYRIGSSVEF 965
            .|..|....|||.||||||:|.|:||:|||||.||:|.|||:||....|:|||.|.|.|||||||
Zfish   918 ARVLRLNQNIRPWVKQIDTLAAEYPAATNYLYCTYHGQEHDLDFKDHGTMVVGCGPYHIGSSVEF 982

  Fly   966 DWCAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILSMG 1030
            |||||..:|.||::.:.|:::|:||||||||:|.||||||||::.|.::||.:.|...|.|:|:|
Zfish   983 DWCAVSSIRALRQMGKRTVVVNHNPETVSTDFDECDRLYFEELTLERILDITQQEGCTGCIVSVG 1047

  Fly  1031 GQLPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCEEV 1095
            ||:|||:||.||....|:|||:|..||.||.|..||.:||..|:.|..|:.|::|:.|:.|...|
Zfish  1048 GQIPNNLAMPLHLNGVKILGTNPAQIDRAEERSVFSSILDDLGVGQAPWRALSSLEDAVSFASNV 1112

  Fly  1096 GYPCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVASDGRI 1160
            |||||:||||||||:||||.|...:::.:|..|::||::|||||:||:..|:|::|||||..|::
Zfish  1113 GYPCLLRPSYVLSGSAMNVVYGEDEMKRFLEEATQVSQDHPVVITKFIRGAREVEVDAVARMGKV 1177

  Fly  1161 LCMAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAKNNELK 1225
            |..|::||||:||||||||||:.|.|.::...||.:|..|..:|...:::||||.|.:.|.|::.
Zfish  1178 LAHAITEHVEDAGVHSGDATLMLPTQTISQGALEKVKTATQKIAKAFEISGPFNTQFLVKGNDVM 1242

  Fly  1226 VIECNVRVSRSFPFVSKTLDHDFVATATRAIVG--LDVEPLDVLHG----VGKVGVKVPQFSFSR 1284
            |||||:|.||||||||||:..||:..|||.:||  :|...|..|..    |..||:|.|.||:.|
Zfish  1243 VIECNLRASRSFPFVSKTIGVDFIDVATRVMVGERMDESRLPSLENPIIPVDFVGIKAPMFSWPR 1307

  Fly  1285 LAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSIGSFKHKMELLPSIRDL 1349
            |..||..|..||||||||||||.|.|.|:||||:||||::|:..:|:.| ....:...|.:...|
Zfish  1308 LREADPVLRCEMASTGEVACFGPNIYSAFLKAMLSTGFKLPQKGILIGI-QHSFRPNFLSTAHQL 1371

  Fly  1350 AKMGYKLYASMGTGDFYAEHGVNVESVQWTFDKTTPDDINGELRHLAEFLANKQFDLVINLPMSG 1414
            .:.|:||||:.||..:...:.|....|.|...:|.    ...|..::..::....|||:|||.:.
Zfish  1372 HEEGFKLYATEGTSAWLNANDVPTIPVAWPSVETN----TTHLPSISRLISEGHIDLVVNLPNNN 1432

  Fly  1415 GGARRVSSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMR 1456
                  |.|:...::.||:||||.:||:|:.:..||..|::|
Zfish  1433 ------SKFLKDNFQIRRMAVDYGVPLITNFQVVKLFAEAIR 1468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rNP_001285343.1 CPSaseIIsmall 7..376 CDD:273580 186/370 (50%)
CPSase_sm_chain 7..151 CDD:279346 72/144 (50%)
GATase1_CPSase 196..371 CDD:153215 94/175 (54%)
CPSaseII_lrg 403..1455 CDD:273581 597/1070 (56%)
CPSase_L_D2 524..726 CDD:280881 145/201 (72%)
CPSase_L_D3 815..935 CDD:280882 55/120 (46%)
P-loop_NTPase 947..>1149 CDD:304359 109/201 (54%)
ATP-grasp_4 1084..1265 CDD:302634 95/182 (52%)
MGS_CPS_I_III 1327..1453 CDD:238711 35/125 (28%)
CAD_DHOase 1475..1821 CDD:238641
PLN02527 1918..2220 CDD:178142
OTCace_N 1919..2060 CDD:280825
OTCace 2067..2216 CDD:278609
cps1XP_683282.4 CPSaseIIsmall 35..390 CDD:273580 186/370 (50%)
CPSase_sm_chain 35..172 CDD:279346 72/144 (50%)
GATase1_CPSase 209..385 CDD:153215 94/175 (54%)
CPSaseII_lrg 407..1467 CDD:273581 597/1071 (56%)
CPSase_L_D2 536..738 CDD:280881 145/201 (72%)
CPSase_L_D3 829..952 CDD:198164 56/122 (46%)
ATP-grasp_4 1078..1279 CDD:302634 103/200 (52%)
MGS_CPS_I_III 1350..1465 CDD:238711 35/125 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 155 1.000 Domainoid score I4181
eggNOG 1 0.900 - - E1_COG0458
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55291
OrthoDB 1 1.010 - - D15670at33208
OrthoFinder 1 1.000 - - FOG0001016
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100435
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1225
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
98.730

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