DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment r and Cps1

DIOPT Version :9

Sequence 1:	NP_001285343.1	Gene:	r / 32640	FlyBaseID:	FBgn0003189	Length:	2224	Species:	Drosophila melanogaster
Sequence 2:	NP_058768.1	Gene:	Cps1 / 497840	RGDID:	2395	Length:	1500	Species:	Rattus norvegicus

Alignment Length:	1477	Identity:	749/1477 - (50%)
Similarity:	1008/1477 - (68%)	Gaps:	72/1477 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YLALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNY 71
            ::.|||||.:.|||||: ||      ...|||||.||:.||:|||||.:|.||||.:..|:|||.
  Rat    47 HIVLEDGTKMKGYSFGH-PS------SVAGEVVFNTGLGGYSEALTDPAYKGQILTMANPIIGNG 104

  Fly    72 GVPAPD---EDEHGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQDID 133
            |  |||   .||.||..:.|  ...::...|:|...:.:..||...|:|..||::.|||.|..:|
  Rat   105 G--APDTTARDELGLNKYME--SDGIKVAGLLVLNYSHDYNHWLATKSLGQWLQEEKVPAIYGVD 165

  Fly   134 TRALTKKLREQGSMLGKIVYEKPPVEGLPKSSFVDPNVRNLAKECSVKERQVYGNPNGKGPRIAI 198
            ||.|||.:|::|:|||||.:|...|:      |||||.:||..|.|.|:.:|:|  .|...::..
  Rat   166 TRMLTKIIRDKGTMLGKIEFEGQSVD------FVDPNKQNLIAEVSTKDVKVFG--KGNPTKVVA 222

  Fly   199 LDCGLKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGPGNPESCDQIVQQVRKVIEEGQK 263
            :|||:|.|.:|.|::|||.|.|:||:.......:|.|.::.|||||.....::|.|:|::|..:|
  Rat   223 VDCGIKNNVIRLLVKRGAEVHLVPWNHDFTQMDYDGLLIAGGPGNPALAQPLIQNVKKILESDRK 287

  Fly   264 -PVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDLEQLPDGWSE 327
             |:|||..|:.:...|.|..:|||...|||.|.|.|:....:..:|:||||||:| ..||.||..
  Rat   288 EPLFGISTGNIITGLAAGAKSYKMSMANRGQNQPVLNITNRQAFITAQNHGYALD-NTLPAGWKP 351

  Fly   328 LFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQQ-KDLTIPQLIEQRLRP 391
            ||||.||.|||||:|.|||:|:||||||...||.|||:|||.|...|:: |..||..::.:
  Rat   352 LFVNVNDQTNEGIMHESKPFFAVQFHPEVSPGPTDTEYLFDSFFSLIKKGKGTTITSVLPK---- 412

  Fly   392 TTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIATVQTSK-G 455
              ||:.::.|...|||||||||||||||||||||||||:|||:|.|::|||:|||||:|||:: |
  Rat   413 --PALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVG 475

  Fly   456 M--ADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVQLERAGVFSKYNVRILGTPIQS 518
            :  ||..||||:||.:|.:|||:|||:|::|..||||||||||:|.:.||..:|.|::|||.::|
  Rat   476 LKQADAVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVES 540

  Fly   519 IIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYPVMARAAFSLGGLGSGFANNEEE 583
            |:.||||:||::::|||.|::|||.||.|:..||.||..:|||||.|:|::|||||||...|:|.
  Rat   541 IMATEDRQLFSDKLNEINEKIAPSFAVESMEDALKAADTIGYPVMIRSAYALGGLGSGICPNKET 605

  Fly   584 LQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCITVCNMENFDPLGIHTGESIVVAPSQ 648
            |..|..:|.|.::|::|::|:.||||:||||||||.:||:|||||||.|.:|:|||:|:||||:|
  Rat   606 LMDLGTKAFAMTNQILVERSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQ 670

  Fly   649 TLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKATGYPLA 713
            |||:.|:||||.|::.|:||.|:|||||||:||.|.|.:|.||||||||||||||||||||||||
  Rat   671 TLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLA 735

  Fly   714 YVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSVGEVMA 778
            ::|||:|||:|||:|||.|:|.|:|||||||||.|.|||||||.:|...|..|||||||||||||
  Rat   736 FIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMA 800

  Fly   779 IGRNFEEAFQKALRMVDSDVLGFDPDVVPLNKE-----QLAEQLSEPTDRRPFVIAAALQLGMSL 838
            |||.|||:|||||||....|.||.|. :|:|||     .|.::||||:..|.:.||.||:..|||
  Rat   801 IGRTFEESFQKALRMCHPSVDGFTPR-LPMNKEWPANLDLRKELSEPSSTRIYAIAKALENNMSL 864

  Fly   839 RELHQLTNIDYWFLEKLERIILL-QSLLTRNGSRTDAALLLKAKRFGFSDKQIAKYIKSTELAVR 902
            .|:.:||:||.|||.|:..|:.: ::|...|........|.:||..|||||||:|.:..||...|
  Rat   865 DEIVKLTSIDKWFLYKMRDILNMDKTLKGLNSESVTEETLRQAKEIGFSDKQISKCLGLTEAQTR 929

  Fly   903 HQRQEFGIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDFPGGHTIVVGSGVYRIGSSVEFDW 967
            ..|.:..|.|.||||||:|.|:|:.|||||.||||.|||:.|.....:|:|.|.|.|||||||||
  Rat   930 ELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDIKFDEHGIMVLGCGPYHIGSSVEFDW 994

  Fly   968 CAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILSMGGQ 1032
            |||..:|.||:|.:.|:::|.||||||||:|.||:|||||:|.|.::|||..|...|.|:|:|||
  Rat   995 CAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACNGCIISVGGQ 1059

  Fly  1033 LPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCEEVGY 1097
            :|||:|:.|::...|::||||..||.||:|..||.:||...:.|..||.:..|..|:||...|||
  Rat  1060 IPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFANSVGY 1124

  Fly  1098 PCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVASDGRILC 1162
            |||:||||||||:||||.:|..:::.:|..|:.||:|||||::||:..|:|:::|||..:||::.
  Rat  1125 PCLLRPSYVLSGSAMNVVFSEDEMKRFLEEATRVSQEHPVVLTKFIEGAREVEMDAVGKEGRVIS 1189

  Fly  1163 MAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAKNNELKVI 1227
            .|:|||||:||||||||||:.|.|.::...:|.:|..|..:|....::||||:|.:.|.|::.||
  Rat  1190 HAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVI 1254

  Fly  1228 ECNVRVSRSFPFVSKTLDHDFVATATRAIVGLDVE------------PLDVLHGVGKVGVKVPQF 1280
            |||:|.|||||||||||..||:..||:.::|..|:            |.|.      |.:|.|.|
  Rat  1255 ECNLRASRSFPFVSKTLGVDFIDVATKVMIGESVDEKHLPTLEQPIIPSDY------VAIKAPMF 1313

  Fly  1281 SFSRLAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSI-GSFKHKMELLP 1344
            |:.||..||..|..||||||||||||:..:.|:||||:||||:||:..:|:.| .||:.:  .|.
  Rat  1314 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR--FLG 1376

  Fly  1345 SIRDLAKMGYKLYASMGTGDFYAEHGVNVESVQWTFDKTTPDDINGELRHLAEFLANKQFDLVIN 1409
            ....|...|:||:|:..|.|:...:.|....|.|    .:.:..|..|..:.:.:.:...|||||
  Rat  1377 VAEQLHNEGFKLFATEATSDWLNANNVPATPVAW----PSQEGQNPSLSSIRKLIRDGSIDLVIN 1437

  Fly  1410 LPMSGGGARRVSSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMR 1456
            ||.:.      :.|:...|..||.|||..|.|:|:.:.|||..|:::
  Rat  1438 LPNNN------TKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAVQ 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_001285343.1	CPSaseIIsmall	7..376	CDD:273580	170/372 (46%)
		CPSase_sm_chain	7..151	CDD:279346	67/146 (46%)
		GATase1_CPSase	196..371	CDD:153215	84/175 (48%)
		CPSaseII_lrg	403..1455	CDD:273581	573/1073 (53%)
		CPSase_L_D2	524..726	CDD:280881	129/201 (64%)
		CPSase_L_D3	815..935	CDD:280882	55/120 (46%)
		P-loop_NTPase	947..>1149	CDD:304359	107/201 (53%)
		ATP-grasp_4	1084..1265	CDD:302634	94/192 (49%)
		MGS_CPS_I_III	1327..1453	CDD:238711	37/126 (29%)
		CAD_DHOase	1475..1821	CDD:238641
		PLN02527	1918..2220	CDD:178142
		OTCace_N	1919..2060	CDD:280825
		OTCace	2067..2216	CDD:278609
Cps1	NP_058768.1	Anthranilate phosphoribosyltransferase homolog	39..218		84/189 (44%)
		CPSaseIIsmall	46..400	CDD:273580	170/372 (46%)
		CPSase_sm_chain	46..183	CDD:279346	67/146 (46%)
		GATase1_CPSase	220..395	CDD:153215	84/175 (48%)
		CPSaseII_lrg	419..1477	CDD:273581	574/1076 (53%)
		CPSase_L_D2	546..748	CDD:280881	129/201 (64%)
		CPSase_L_D3	839..962	CDD:198164	56/122 (46%)
		ATP-grasp_4	1088..1289	CDD:302634	100/200 (50%)
		MGS_CPS_I_III	1360..1475	CDD:238711	37/126 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0458
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55291
OrthoDB	1	1.010	-	-		D15670at33208
OrthoFinder	1	1.000	-	-		FOG0001016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100435
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1225
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730