DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment r and cad

DIOPT Version :9

Sequence 1:	NP_001285343.1	Gene:	r / 32640	FlyBaseID:	FBgn0003189	Length:	2224	Species:	Drosophila melanogaster
Sequence 2:	XP_009293160.1	Gene:	cad / 266992	ZFINID:	ZDB-GENE-021030-4	Length:	2256	Species:	Danio rerio

Alignment Length:	2292	Identity:	1421/2292 - (61%)
Similarity:	1735/2292 - (75%)	Gaps:	115/2292 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASTDCYLALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTY 65
            |||    |.|||||...|..||.|.|       ..||||||||||||.|||||.||..|||.|||
Zfish     5 MAS----LVLEDGTTFKGRLFGAVSS-------VSGEVVFQTGMVGYPEALTDPSYKSQILTLTY 58

  Fly    66 PLIGNYGVPAPDEDEHGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQ 130
            |:|||||:|..::.|.||...||  ...:.|.||:||||:|...||...|:|.:||::..:||:|
Zfish    59 PMIGNYGIPKDEDGEFGLSKWFE--SSQIHAAALIVGEVSENPSHWSAAKSLDEWLREQGIPGLQ 121

  Fly   131 DIDTRALTKKLREQGSMLGKIVYEKPPVEGLPKSSFVDPNVRNLAKECSVKERQVYGNPNGKGPR 195
            .:|||.||||:||:|:||||:|.|..|.:.:|   |.:|:.|||.||.|:|..:|: ||.|. .|
Zfish   122 GVDTRCLTKKIREKGTMLGKLVVEGTPADNIP---FDNPDARNLVKEVSMKAPKVF-NPEGT-VR 181

  Fly   196 IAILDCGLKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGPGNPESCDQIVQQVRKV-IE 259
            |..:|||:|.||:|||.||||.||::||...|:...||.||:||||||||.|.:.|:.:||| ..
Zfish   182 ITAIDCGIKYNQIRCLCQRGARVTVVPWDQPLDSNDFDGLFISNGPGNPEYCKETVENIRKVACV 246

  Fly   260 EGQKPVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDLEQLPDG 324
            |..||:||||||||||:..||..||||||||||||.||:|:.|.||.:||||||:|||.|.||..
Zfish   247 ENPKPIFGICLGHQLLSLVIGAKTYKMKYGNRGHNQPCIHKGTSRCYITSQNHGFAVDPETLPKD 311

  Fly   325 WSELFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQQ-KDLTIPQLIEQR 388
            |..||.||||.|:|||||..||.|||||||||.|||.|...|||||:::::. |:....:.::||
Zfish   312 WDVLFTNANDQTSEGIVHNHKPLFSVQFHPEHMAGPTDLVGLFDVFLDTVRDVKENKAGKSVKQR 376

  Fly   389 LR-----PTTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIA 448
            |.     |.:|. .:|.|.|||||:|||||||||||||||||||||||||:|.||||:|||||||
Zfish   377 LMEHLTFPGSPD-PNAFVRPRKVLVLGSGGLSIGQAGEFDYSGSQAIKAMKEENIQTILINPNIA 440

  Fly   449 TVQTSKGMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVQLERAGVFSKYNVRILG 513
            |||||||:|||.||||:||.||.||||:|||:||||||||||||||||:|::.||..||.||:||
Zfish   441 TVQTSKGLADKVYFLPITPEYVTQVIKNERPDGVLLTFGGQTALNCGVELKKQGVLEKYKVRVLG 505

  Fly   514 TPIQSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYPVMARAAFSLGGLGSGFA 578
            ||:.||..|||||:|.|::.||.|.||||||..||.||:.||.||||||:.|:||:|||||||||
Zfish   506 TPVASIEMTEDRKIFVEKMEEINEHVAPSEAAMSVEQAVAAAERLGYPVLVRSAFALGGLGSGFA 570

  Fly   579 NNEEELQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCITVCNMENFDPLGIHTGESIV 643
            ||.:|:.:|..||.||:||::||||||||||:|||||||||:||:|||||||.||||||||||||
Zfish   571 NNRDEMITLVTQAFAHTSQVLVDKSLKGWKEIEYEVVRDAYDNCVTVCNMENIDPLGIHTGESIV 635

  Fly   644 VAPSQTLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKAT 708
            |||||||:|.||.|||:||:|||||.||||||||||||.|.||||||||||||||||||||||||
Zfish   636 VAPSQTLNDYEYNMLRNTAIKVIRHLGVVGECNIQYALNPESEQYYIIEVNARLSRSSALASKAT 700

  Fly   709 GYPLAYVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSV 773
            |||||||||||:||:|||.:|||||.:|||.|||||||||||:|||||:||:|||..||||||||
Zfish   701 GYPLAYVAAKLSLGIPLPVLKNSVTNSTTANFEPSLDYCVVKVPRWDLSKFLRVSTKIGSSMKSV 765

  Fly   774 GEVMAIGRNFEEAFQKALRMVDSDVLGFDPDVVPLNKEQLAEQLSEPTDRRPFVIAAALQLGMSL 838
            ||||||||:|||||||||||||.:.:|||..:.|    :..|:|..|||:|.||:||||..|.::
Zfish   766 GEVMAIGRSFEEAFQKALRMVDENCVGFDHTIKP----ESEEELQTPTDKRIFVLAAALHAGYTV 826

  Fly   839 RELHQLTNIDYWFLEKLERIILLQSLL---TRNGSRTDAALLLKAKRFGFSDKQIAKYIKSTELA 900
            ..|::||.||:|||.|::.|...:.||   .::.|.....::.|||:.||||||||:.::|||||
Zfish   827 ERLYELTKIDHWFLHKMKNIADHKKLLETYKQDESAMPPEIMRKAKQLGFSDKQIAQAVQSTELA 891

  Fly   901 VRHQRQEFGIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDFPGGHTIVVGSGVYRIGSSVEF 965
            ||..|:::.|.|.||||||||.||||.|||||.||:|||.||.|...|.:|:|||||||||||||
Zfish   892 VRKLRRDWKIFPVVKQIDTVAAEWPAQTNYLYLTYHGSESDVVFEQPHVMVIGSGVYRIGSSVEF 956

  Fly   966 DWCAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILSMG 1030
            |||||||:.||||:...|||:|||||||||||||||||||:|||||||||||||||.||:|||||
Zfish   957 DWCAVGCIMELRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYEMENPEGVILSMG 1021

  Fly  1031 GQLPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCEEV 1095
            |||||||||.|||||.::||||||.||.||||||||||||..||.|||||||::.:||:.|||.|
Zfish  1022 GQLPNNIAMSLHRQQCRILGTSPEFIDNAENRFKFSRMLDTIGISQPRWKELSDTESAVNFCETV 1086

  Fly  1096 GYPCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVASDGRI 1160
            ||||||||||||||||||||||:.|:|.:|::|..||:|||||||||:.|||||||||||.||.:
Zfish  1087 GYPCLVRPSYVLSGAAMNVAYSDTDMEKFLSSAVAVSKEHPVVISKFIQEAKEIDVDAVACDGEV 1151

  Fly  1161 LCMAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAKNNELK 1225
            :.:||||||||||||||||||||||||:|.:|:|.||.|...:...|.||||||:|||||:::||
Zfish  1152 IAIAVSEHVENAGVHSGDATLVTPPQDINQKTMERIKMIVHAIGQELQVTGPFNLQLIAKDDQLK 1216

  Fly  1226 VIECNVRVSRSFPFVSKTLDHDFVATATRAIVGLDVEPLDVLHGVGKVGVKVPQFSFSRLAGADV 1290
            |||||||||||||:|||||..|.||.|||.|:|.:||.:.::.|.|.||||||||||||||||||
Zfish  1217 VIECNVRVSRSFPYVSKTLGVDLVALATRVILGEEVEAVGLMRGNGIVGVKVPQFSFSRLAGADV 1281

  Fly  1291 QLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSIGSFKHKMELLPSIRDLAKMGYK 1355
            .|||||.|||||||||:||||||||||:||||:|||..:||||||:|:|.||||:::.|..:||.
Zfish  1282 VLGVEMTSTGEVACFGENRYEAYLKAMLSTGFKIPKKNILLSIGSYKNKSELLPTVQTLESLGYN 1346

  Fly  1356 LYASMGTGDFYAEHGVNVESVQWTFDKTTPDDINGELRHLAEFLANKQFDLVINLPMSGGGARRV 1420
            ||||:||.|||.||||.|.:|.|.|::.:......:.|::.::|....|||||||.|...|.||:
Zfish  1347 LYASLGTADFYTEHGVKVMAVDWPFEEESDCPNKDKQRNIMDYLEENHFDLVINLSMRNSGGRRL 1411

  Fly  1421 SSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMRMNGGKPPMKTHTDCMTSRRIVKLPGFIDV 1485
            |||:|.||||||:|:|:|:||:||:|||||.|::::..|..|.:|||.|.|||:::::|||.|||
Zfish  1412 SSFVTKGYRTRRMAIDFSVPLITDIKCTKLFVQALKQIGQAPRVKTHVDSMTSQKLIRLPGLIDV 1476

  Fly  1486 HVHLREPGATHKEDFASGTAAALAGGVTLVCAMPNTNPSIVDRETFTQFQELAKAGARCDYALYV 1550
            |||||||||||||||:||||||||||:|:|||||||||:|:|..:||..|:|||||.||||||:|
Zfish  1477 HVHLREPGATHKEDFSSGTAAALAGGITMVCAMPNTNPAIIDPNSFTMAQKLAKAGCRCDYALFV 1541

  Fly  1551 GASDDNWAQVNELASHACGLKMYLNDTFGTLKLSDMTSWQRHLSHWPKRSPIVCHAERQSTAAVI 1615
            |||.||.|.:..:||...|||||||||:.|||:.:::.|..|...|||..|||.|||:|:.||::
Zfish  1542 GASSDNAALLPSIASSTAGLKMYLNDTYSTLKMDNVSLWMEHFEKWPKHLPIVAHAEKQTVAAIL 1606

  Fly  1616 MLAHLLDRSVHICHVARKEEIQLIRSAKEKGVKVTCEVCPHHLFLSTKDVERLGHGMSEVRPLLC 1680
            ::|.|..|.|||||||:||||.:||:||:||::|||||.||||||...:|..:|...::|||:|.
Zfish  1607 LVAQLYQRPVHICHVAKKEEILIIRAAKQKGIQVTCEVAPHHLFLCEDNVPVIGKDKAQVRPMLG 1671

  Fly  1681 SPEDQEALWENIDYIDVFATDHAPHTLAEKRSERPPPGFPGVETILPLLLQAVHEGRLTMEDIKR 1745
            :.||.||||||:|.||.||||||||:..||.||:||||:||:||:||||..||.|||||::||.:
Zfish  1672 TREDMEALWENLDIIDCFATDHAPHSAEEKISEKPPPGYPGLETMLPLLFTAVSEGRLTVDDIIK 1736

  Fly  1746 KFHRNPKIIFNLPDQAQTYVEVDLDEEWTITGNEMKSKSGWTPFEGTKVKGRVHRVVLRGEVAFV 1810
            :.:.||:.||:||.|..|||||||::||.|..:...:||.||||||.||||:|.|||||||||::
Zfish  1737 RLYENPRKIFSLPAQEDTYVEVDLEQEWIIPKHMQFTKSKWTPFEGMKVKGKVMRVVLRGEVAYI 1801

  Fly  1811 DGQVLVQPGFGQNVRP-KQSPLASEASQDLLPSDNDANDTFTRLLTSEGPGGGVHGISTKVHFVD 1874
            ||||||.||:||:|:. ..:|.|:  ::.::    ||.......:|.|.|....
Zfish  1802 DGQVLVPPGYGQDVKSWSATPTAT--TEVIM----DAPKRVIEAMTPERPRQAA----------- 1849

  Fly  1875 GANFLRPNSPSPR-----------IRLDSASNTTLREYLQRTT---------------------- 1906
            ..:.:|..:||||           .|:..:|:..|....:|:|
Zfish  1850 PVDVVRSRAPSPRRSAGDGRFILPPRIHRSSDPGLPPGFKRSTMHPQKAFAEEEVSLRAPFDAEL 1914

  Fly  1907 ------------------------------NSNPVAHSLMGKHILAVDMFNKDHLNDIFNLAQLL 1941
                                          .::|:.|.|:|:|||:|..|:|:.::.:||:|..|
Zfish  1915 ALPAEAYAHPPPLARILSPQAGQPQILPHPQTSPLLHPLVGQHILSVRQFSKEQMSHLFNVAHTL 1979

  Fly  1942 KLRGTKDRPVDELLPGKIMASVFYEVSTRTQCSFAAAMLRLGGRVISMDNITSSVKKGESLEDSI 2006
            :|...|:||:| :|.||:|||:||||||||..||||||.||||.|:.....|||.:|||||.||:
Zfish  1980 RLMVQKERPLD-ILKGKVMASMFYEVSTRTSSSFAAAMHRLGGSVVHFCESTSSTQKGESLVDSV 2043

  Fly  2007 KVVSSYADVVVLRHPSPGAVARAATFSRKPLINAGDGVGEHPTQALLDIFTIREEFGTVNGLTIT 2071
            ..:|.||||:|||||.||||..||...|:|:||||||||||||||||||||||||.|||||:|||
Zfish  2044 NTMSCYADVIVLRHPIPGAVESAARHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTIT 2108

  Fly  2072 MVGDLKNGRTVHSLARLLTLYNVNLQYVAPNSLQMPDEVVQFVHQRGVKQLFARDLKNVLPDTDV 2136
            ||||||:||||||||||||.|.:.|:||||.:|.||.|::.||..:|:||.....::..||||||
Zfish  2109 MVGDLKHGRTVHSLARLLTQYRITLRYVAPKNLSMPAEIIDFVASKGIKQEEFNSIEEALPDTDV 2173

  Fly  2137 LYMTRIQRERFDNVEDYEKCCGHLVLTPEHMMRAKKRSIVLHPLPRLNEISREIDSDPRAAYFRQ 2201
            |||||||:|||.:.::|..|.|..:|||..|..||::.:|:|||||:||||.|:|:|||||||||
Zfish  2174 LYMTRIQKERFSSEKEYNACFGQFILTPHIMTGAKRKMVVMHPLPRVNEISVEVDTDPRAAYFRQ 2238

  Fly  2202 AEYGMYIRMALLAMVVG 2218
            ||.||||||||||.|:|
Zfish  2239 AENGMYIRMALLATVLG 2255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_001285343.1	CPSaseIIsmall	7..376	CDD:273580	211/369 (57%)
		CPSase_sm_chain	7..151	CDD:279346	78/143 (55%)
		GATase1_CPSase	196..371	CDD:153215	113/175 (65%)
		CPSaseII_lrg	403..1455	CDD:273581	753/1054 (71%)
		CPSase_L_D2	524..726	CDD:280881	159/201 (79%)
		CPSase_L_D3	815..935	CDD:280882	64/122 (52%)
		P-loop_NTPase	947..>1149	CDD:304359	159/201 (79%)
		ATP-grasp_4	1084..1265	CDD:302634	128/180 (71%)
		MGS_CPS_I_III	1327..1453	CDD:238711	67/125 (54%)
		CAD_DHOase	1475..1821	CDD:238641	220/345 (64%)
		PLN02527	1918..2220	CDD:178142	193/301 (64%)
		OTCace_N	1919..2060	CDD:280825	89/140 (64%)
		OTCace	2067..2216	CDD:278609	95/148 (64%)
cad	XP_009293160.1	PRK12564	4..359	CDD:237139	214/371 (58%)
		CPSase_sm_chain	6..142	CDD:279346	80/148 (54%)
		GATase1_CPSase	182..358	CDD:153215	113/175 (65%)
		CPSaseII_lrg	395..1446	CDD:273581	753/1054 (71%)
		CPSase_L_D2	516..718	CDD:280881	159/201 (79%)
		CPSase_L_D3	803..926	CDD:280882	64/122 (52%)
		ATP-grasp_4	1074..1250	CDD:302634	125/175 (71%)
		MGS_CPS_I_III	1318..1444	CDD:238711	67/125 (54%)
		CAD_DHOase	1466..1812	CDD:238641	220/345 (64%)
		pyrB	1952..2256	CDD:234849	195/305 (64%)
		OTCace_N	1957..2097	CDD:280825	89/140 (64%)
		OTCace	2104..2253	CDD:278609	95/148 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590858
Domainoid	1	1.000	380	1.000	Domainoid score	I803
eggNOG	1	0.900	-	-		E1_COG0458
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1412
Inparanoid	1	1.050	2742	1.000	Inparanoid score	I24
OMA	1	1.010	-	-		QHG55291
OrthoDB	1	1.010	-	-		D15670at33208
OrthoFinder	1	1.000	-	-		FOG0001016
OrthoInspector	1	1.000	-	-		oto40565
orthoMCL	1	0.900	-	-		OOG6_100435
Panther	1	1.100	-	-	LDO	PTHR11405
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1225
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810