DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment r and ura1

DIOPT Version :9

Sequence 1:	NP_001285343.1	Gene:	r / 32640	FlyBaseID:	FBgn0003189	Length:	2224	Species:	Drosophila melanogaster
Sequence 2:	NP_593055.1	Gene:	ura1 / 2541544	PomBaseID:	SPAC22G7.06c	Length:	2244	Species:	Schizosaccharomyces pombe

Alignment Length:	2261	Identity:	1112/2261 - (49%)
Similarity:	1482/2261 - (65%)	Gaps:	123/2261 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNYG 72
            |.|||.:||.|||||       :.....||:|||||||||.|:|||.||.|||||.|:|.:||||
pombe    61 LELEDKSVLQGYSFG-------ADHSVSGELVFQTGMVGYPESLTDPSYRGQILVFTFPTVGNYG 118

  Fly    73 VPAPDE---DE-HGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQDID 133
            |  ||.   || .|||.:||  ...:...|:::...::...|:....:|.:|||:..:|||..||
pombe   119 V--PDRRILDEISGLPKYFE--SNQIHVAAIIISSYSQNYSHFLAHSSLGEWLKEQGIPGIFGID 179

  Fly   134 TRALTKKLREQGSMLGKIVYEK-------PPVEGLPK---SSFVD-----PNVRNLAKECSVKER 183
            |||||||:|:||||||:::.:|       ..:.||.|   ::|.|     ||..||..:.|:||.
pombe   180 TRALTKKIRDQGSMLGRLLIQKDESPINPSSITGLGKDWSTAFEDIPWKNPNTENLTSQVSIKEP 244

  Fly   184 QVY--------GNPNGKGPRIAILDCGLKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNG 240
            ::|        ...:||..||.::|.|:|.||:||.|.||..:.::||......|.:|.||:|||
pombe   245 KLYEPHPTTAIKKADGKIIRILVIDVGMKYNQIRCFLNRGVELLVVPWDYDFTKETYDGLFISNG 309

  Fly   241 PGNPESCDQIVQQVRKVIEEGQKPVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRC 305
            ||:|...|.:|.:|::|:|....||||||.|||::|:|.|.||.|||:||||||:||....:|||
pombe   310 PGDPSLMDLVVDRVKRVLESKTVPVFGICFGHQIMARAAGASTTKMKFGNRGHNIPCTCMISGRC 374

  Fly   306 LMTSQNHGYAVDLEQLPDGWSELFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVF 370
            .:||||||||||...|.:||.|||||||||:||||.:...|:||||||||...||:|||||||||
pombe   375 YITSQNHGYAVDASSLSNGWKELFVNANDGSNEGIYNTEYPFFSVQFHPESTPGPRDTEFLFDVF 439

  Fly   371 MESIQQ-------KDLTIPQLIEQRLRPTTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQ 428
            ::.:::       :...:|....:..|...|.:|:     ::|||||||||||||||||||||||
pombe   440 IDVVKRSADAKSLQPFKLPGGTIEENRSRHPLVDA-----KRVLILGSGGLSIGQAGEFDYSGSQ 499

  Fly   429 AIKAMRESNIQTVLINPNIATVQTSKGMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALN 493
            ||||:||..|.|:||||||||:|||||:|||.||||:...:|.:|||.|||:.:.:|||||||||
pombe   500 AIKALREEGIYTILINPNIATIQTSKGLADKVYFLPVNADFVRKVIKQERPDSIYVTFGGQTALN 564

  Fly   494 CGVQLERAGVFSKYNVRILGTPIQSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRL 558
            .|::|:  ..|.:..|::|||||.:||.||||:|||..::||.|:.|.|.:..|:.:|:..:..:
pombe   565 VGIELK--DEFEQLGVKVLGTPIDTIITTEDRELFARAMDEINEKCAKSASASSIEEAIKVSKDI 627

  Fly   559 GYPVMARAAFSLGGLGSGFANNEEELQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCI 623
            .:||:.|||::|||||||||:||.||..|...|.|.|.|:::::|:|||||:||||||||::|||
pombe   628 SFPVIVRAAYALGGLGSGFADNEAELIDLCTLAFATSPQVLIERSMKGWKEIEYEVVRDAFDNCI 692

  Fly   624 TVCNMENFDPLGIHTGESIVVAPSQTLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQY 688
            ||||||||||||||||:||||||||||:|.:|.|||:||:.||||.||||||||||||.|.:::|
pombe   693 TVCNMENFDPLGIHTGDSIVVAPSQTLTDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFTKEY 757

  Fly   689 YIIEVNARLSRSSALASKATGYPLAYVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPR 753
            .||||||||||||||||||||||||:.||||.|.:||.::|||||..|.|||||||||.||||||
pombe   758 CIIEVNARLSRSSALASKATGYPLAFTAAKLGLNIPLNEVKNSVTKVTCACFEPSLDYVVVKIPR 822

  Fly   754 WDLAKFVRVSKHIGSSMKSVGEVMAIGRNFEEAFQKALRMVDSDVLGFDPDVVPLNKEQLAE--- 815
            |||.||.|||..:.|:||||||||:|||.||||.|||:|.:|....||:.      |:.|..
pombe   823 WDLKKFTRVSTQLSSAMKSVGEVMSIGRTFEEAIQKAIRAIDYSNTGFNV------KDALMSIDT 881

  Fly   816 QLSEPTDRRPFVIAAALQLGMSLRELHQLTNIDYWFLEKLERIILLQSLLTRNG-SRTDAALLLK 879
            :|..|:|:|.|.||.|:..|.|:..:.:||.||.||||||..:|....|::::. |....:||..
pombe   882 ELQTPSDQRLFAIANAMASGYSVDRIWELTRIDKWFLEKLMGLIRTSQLISKHDISSLPISLLKT 946

  Fly   880 AKRFGFSDKQIAKYIKSTELAVRHQRQEFGIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDF 944
            ||:.||:|.|||.::.|||||||..|.|.||||.||||||||.|:||.|||||.|||..|||:.|
pombe   947 AKQLGFADVQIAAFMNSTELAVRRIRTEAGIRPFVKQIDTVAAEFPAFTNYLYTTYNAVEHDIHF 1011

  Fly   945 PGGHTIVVGSGVYRIGSSVEFDWCAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEIS 1009
            .....:|:||||||||||||||||||..:|.||.....|||:||||||||||||..||||||.|.
pombe  1012 NDKGVMVLGSGVYRIGSSVEFDWCAVRAVRTLRDRGVKTIMVNYNPETVSTDYDEADRLYFENIG 1076

  Fly  1010 FEVVMDIYEMENSEGIILSMGGQLPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGI 1074
            .|.|:||||.|:|.|||::||||..||||:.|||:..|:||||||.||.||||||||||||..|:
pombe  1077 LETVLDIYEQESSSGIIIAMGGQTANNIALPLHRENVKILGTSPEMIDGAENRFKFSRMLDDIGV 1141

  Fly  1075 LQPRWKELTNLQSAIEFCEEVGYPCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVI 1139
            .||:|||||:...|.:||:.||||.||||||||||||||..||..||.:||..|..::::|||||
pombe  1142 DQPKWKELTSFDEADKFCDTVGYPVLVRPSYVLSGAAMNTVYSQSDLHSYLQQAVAINKDHPVVI 1206

  Fly  1140 SKFLTEAKEIDVDAVASDGRILCMAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLA 1204
            ||::..||||::||||.:|:::...:|||||||||||||||||.|||||...|:|.|......:.
pombe  1207 SKYIENAKEIELDAVAREGKMVMHVISEHVENAGVHSGDATLVLPPQDLAPTTIERIVDAAAKIG 1271

  Fly  1205 SVLDVTGPFNMQLIAKNNELKVIECNVRVSRSFPFVSKTLDHDFVATATRAIVGLDVEPL-DVLH 1268
            ..|::|||:|:|.|||:||:||||||||.|||||||||.:..|.::.||..|:|..::|. ||..
pombe  1272 EALNITGPYNIQFIAKDNEIKVIECNVRASRSFPFVSKVIGVDMISMATDVIMGNPIQPYPDVDL 1336

  Fly  1269 GVGKVGVKVPQFSFSRLAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSI 1333
            ....|.|||||||||||:|||..|||||||||||||||.|::|||||||:||||::||..:|:||
pombe  1337 PRDYVAVKVPQFSFSRLSGADPVLGVEMASTGEVACFGHNKFEAYLKAMISTGFRLPKKNILISI 1401

  Fly  1334 GSFKHKMELLPSIRDLAKMGYKLYASMGTGDFYAEHGVNVESVQWTFDKTTPDDINGELRHLAEF 1398
            ||:|.|.||||.::.|.:..|.::|:.||.|::.|.||..:.:.    ....::.|.|. .|:..
pombe  1402 GSYKEKAELLPYVKKLYENNYNIFATAGTSDYFMESGVPCKYLA----DLPAEEANNEY-SLSAH 1461

  Fly  1399 LANKQFDLVINLPMSGGGARRVSSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMRMNGGKPP 1463
            |||...|:.|||| |....||.:::::.||::||||:|||:||||:|||.||::|::..|  ...
pombe  1462 LANNMIDMYINLP-SNNRYRRPANYISSGYKSRRLAIDYSVPLVTNVKCAKLMIEAICRN--LDF 1523

  Fly  1464 MKTHTDCMTSRRIVKLPGFIDVHVHLREPGATHKEDFASGTAAALAGGVTLVCAMP-NTNPSIVD 1527
            ..:..|..:|.:...|||.|::...|.|..:....|:   |...:|.|.|:...:| :|:.::.|
pombe  1524 SLSTVDFQSSFQTANLPGLINISAFLPEFTSEAVSDY---TKECIASGFTMARFLPFSTSSTLAD 1585

  Fly  1528 RETFTQFQELAKAGARCDYALYVGASDDNWAQVNELASHA-CGLKMYLNDTFGTLKLSDMTSWQR 1591
            :::.:..::||...|.|||...|.||..|...::||.|.: |....:..|..|   :..:|:...
pombe  1586 KDSLSAVKKLALDHAHCDYNFSVIASSTNEVTISELTSESGCLFFHFEKDDSG---IDHVTAVAS 1647

  Fly  1592 HLSHWPKRSPIVCHAERQSTAAVIMLAHLLDRSVHICHVARKEEIQLIRSAKEKGVKVTCEVCPH 1656
            |.:.||....::..|:..:.|::::||.|.:|.:||.:|:.|:::.||..||::.:.||.:|..:
pombe  1648 HFNVWPDTQTVMTDAKSTTLASLLLLASLHNRRIHITNVSSKDDLNLIVLAKQRSLPVTFDVSVY 1712

  Fly  1657 HLFLSTKDVERLGHGMSEVRPLLCSPEDQEALWENIDYIDVFATDHAPHTLAEKRSERPPPGFPG 1721
            .|||:..|..    |.:    .|.:.:||..:|..:.|||.|:....|..||:........|| |
pombe  1713 SLFLNQNDYP----GAT----FLPTADDQVEIWNKLSYIDCFSIGSIPSRLAKFVGNTAFTGF-G 1768

  Fly  1722 VETILPLLLQAVHEGRLTMEDIKRKFHRNPKIIFNLPDQAQTYVEVDLDE--EWTITGNEMKSKS 1784
            |...:||||.||:|||||::|:..:|:.|||.||.|.||..:.|::::|.  .|        |..
pombe  1769 VREAIPLLLTAVNEGRLTLKDVVDRFYSNPKAIFRLHDQDDSGVQLEVDRSVSW--------SSK 1825

  Fly  1785 GWTPFEGTKVKGRVHRVVLRGEVAFVDGQVLVQPGFGQNVRPKQSPLASEASQDLLPSDNDANDT 1849
            .||||.|.|:.|.:..|...|...|.||::..:..:|::.        |.||   |...:.|...
pombe  1826 DWTPFNGKKLYGSIQSVQFDGHDVFFDGELNFEHTYGRDY--------SSAS---LADKSKATRK 1879

  Fly  1850 FTRLLTSEGPGGGVHGISTKVHFVDGANFLRPNSPSPRIRLDSASNTTLREYLQRTTNSNPVAHS 1914
            .:.|::...|    |...:   ..:.......|...|.|.|:...|......|.:..||:|
pombe  1880 VSALMSPGLP----HAAPS---LAEAFGQAPENKAHPDISLNMTPNFKPSHELVQLINSSP---- 1933

  Fly  1915 LMGKHILAVDMFNKDHLNDIFNLAQLLKLRGTKDRPVDELLPGKIMASVFYEVSTRTQCSFAAAM 1979
            ...|||::|....:..|:.:|.:|..:::...:...:| |..||::.::|:|.||||..||.|||
pombe  1934 FYRKHIISVHQVTRSDLHVLFAIAHQMRIIVERQGVID-LCYGKLLCTMFFEPSTRTSSSFDAAM 1997

  Fly  1980 LRLGGRVISMDNITSSVKKGESLEDSIKVVSSYADVVVLRHPSPGAVARAATFSRKPLINAGDGV 2044
            .||||:|:::....|||.|||||.|:|:.:..|.|.:||||||..:...||.||..|:||.|:|.
pombe  1998 QRLGGKVVAVTASASSVNKGESLADTIRTLGCYGDAIVLRHPSIESARIAANFSPVPIINGGNGS 2062

  Fly  2045 GEHPTQALLDIFTIREEFGTVNGLTITMVGDLKNGRTVHSLARLLTLYNVNLQYVAPNSLQMPDE 2109
            .||||||.||::|||||.|:|||||||.:||||.|||||||||||..::|.|..|:|..|.:||:
pombe  2063 KEHPTQAFLDLYTIREELGSVNGLTITFIGDLKYGRTVHSLARLLAFWHVELHLVSPEQLALPDD 2127

  Fly  2110 VVQFVHQRGVKQLFARDL-KNVLPDTDVLYMTRIQRERFDNVEDYEKCCGHLVLTPEHMMRAKKR 2173
            |...:...|:..:..|:| |.|:..:||||.||:|:|||.:|::|||.....::....:..||..
pombe  2128 VKDDIRANGLNFIEHRELTKEVVAQSDVLYCTRVQKERFASVDEYEKLKDSFIVDNSVLASAKSH 2192

  Fly  2174 SIVLHPLPRLNEISREIDSDP-RAAYFRQAEYGMYIRMALLAMVVGGRNTA 2223
            .||:|||||..|||.|:|.|. |||||||..||:||||||||.|:|....|
pombe  2193 CIVMHPLPRNREISEEVDFDQRRAAYFRQMRYGLYIRMALLACVMGATEVA 2243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_001285343.1	CPSaseIIsmall	7..376	CDD:273580	193/394 (49%)
		CPSase_sm_chain	7..151	CDD:279346	74/146 (51%)
		GATase1_CPSase	196..371	CDD:153215	101/174 (58%)
		CPSaseII_lrg	403..1455	CDD:273581	634/1056 (60%)
		CPSase_L_D2	524..726	CDD:280881	133/201 (66%)
		CPSase_L_D3	815..935	CDD:280882	62/123 (50%)
		P-loop_NTPase	947..>1149	CDD:304359	132/201 (66%)
		ATP-grasp_4	1084..1265	CDD:302634	103/181 (57%)
		MGS_CPS_I_III	1327..1453	CDD:238711	52/125 (42%)
		CAD_DHOase	1475..1821	CDD:238641	108/349 (31%)
		PLN02527	1918..2220	CDD:178142	151/303 (50%)
		OTCace_N	1919..2060	CDD:280825	63/140 (45%)
		OTCace	2067..2216	CDD:278609	79/150 (53%)
ura1	NP_593055.1	CarA	57..449	CDD:223579	193/398 (48%)
		CPSase_sm_chain	61..197	CDD:279346	74/146 (51%)
		GATase1_CPSase	265..440	CDD:153215	101/174 (58%)
		CPSaseII_lrg	473..1517	CDD:273581	635/1062 (60%)
		CPSase_L_D2	593..795	CDD:280881	133/201 (66%)
		CPSase_L_D3	882..1002	CDD:280882	62/119 (52%)
		ATP-grasp_4	1151..1328	CDD:302634	102/176 (58%)
		MGS_CPS_I_III	1395..1515	CDD:238711	52/125 (42%)
		CAD_DHOase	1535..1862	CDD:238641	108/349 (31%)
		PyrB	1931..2242	CDD:223614	153/315 (49%)
		OTCace_N	1938..2078	CDD:280825	63/140 (45%)
		OTCace	2085..2234	CDD:278609	77/148 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	232	1.000	Domainoid score	I496
eggNOG	1	0.900	-	-		E1_COG0458
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1412
Inparanoid	1	1.050	1915	1.000	Inparanoid score	I4
OMA	1	1.010	-	-		QHG55291
OrthoFinder	1	1.000	-	-		FOG0001016
OrthoInspector	1	1.000	-	-		oto102159
orthoMCL	1	0.900	-	-		OOG6_100435
Panther	1	1.100	-	-	O	PTHR11405
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1046
SonicParanoid	1	1.000	-	-		X1225
TreeFam	1	0.960	-	-
	14	13.860