DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment r and CPS1

DIOPT Version :9

Sequence 1:	NP_001285343.1	Gene:	r / 32640	FlyBaseID:	FBgn0003189	Length:	2224	Species:	Drosophila melanogaster
Sequence 2:	NP_001356185.1	Gene:	CPS1 / 1373	HGNCID:	2323	Length:	1511	Species:	Homo sapiens

Alignment Length:	1477	Identity:	751/1477 - (50%)
Similarity:	1013/1477 - (68%)	Gaps:	72/1477 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YLALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNY 71
            ::.|||||.:.|||||: ||      ...|||||.||:.||.||:||.:|.||||.:..|:|||.
Human    58 HIVLEDGTKMKGYSFGH-PS------SVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNG 115

  Fly    72 GVPAPDE---DEHGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQDID 133
            |  |||.   ||.||..:.|  ...::.:.|:|.:.:::..||...|:|..||::.|||.|..:|
Human   116 G--APDTTALDELGLSKYLE--SNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVD 176

  Fly   134 TRALTKKLREQGSMLGKIVYEKPPVEGLPKSSFVDPNVRNLAKECSVKERQVYGNPNGKGPRIAI 198
            ||.|||.:|::|:|||||.:|..||:      |||||.:||..|.|.|:.:|||  .|...::..
Human   177 TRMLTKIIRDKGTMLGKIEFEGQPVD------FVDPNKQNLIAEVSTKDVKVYG--KGNPTKVVA 233

  Fly   199 LDCGLKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGPGNPESCDQIVQQVRKVIEEGQK 263
            :|||:|.|.:|.|::|||.|.|:||:......::|.:.::.|||||...:.::|.|||::|..:|
Human   234 VDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRK 298

  Fly   264 -PVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDLEQLPDGWSE 327
             |:|||..|:.:...|.|..||||...|||.|.|.|:....:..:|:||||||:| ..||.||..
Human   299 EPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALD-NTLPAGWKP 362

  Fly   328 LFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQQ-KDLTIPQLIEQRLRP 391
            ||||.||.|||||:|.|||:|:||||||...||.|||:|||.|...|:: |..||..::.:
Human   363 LFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPK---- 423

  Fly   392 TTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIATVQTSK-G 455
              ||:.::.|...|||||||||||||||||||||||||:|||:|.|::|||:|||||:|||:: |
Human   424 --PALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVG 486

  Fly   456 M--ADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVQLERAGVFSKYNVRILGTPIQS 518
            :  ||..||||:||.:|.:|||:|:|:|::|..||||||||||:|.:.||..:|.|::|||.::|
Human   487 LKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVES 551

  Fly   519 IIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYPVMARAAFSLGGLGSGFANNEEE 583
            |:.||||:||::::|||.|::|||.||.|:..||.||..:|||||.|:|::|||||||...|.|.
Human   552 IMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRET 616

  Fly   584 LQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCITVCNMENFDPLGIHTGESIVVAPSQ 648
            |..|:.:|.|.::|::|:||:.||||:||||||||.:||:|||||||.|.:|:|||:|:||||:|
Human   617 LMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQ 681

  Fly   649 TLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKATGYPLA 713
            |||:.|:||||.|::.|:||.|:|||||||:||.|.|.:|.||||||||||||||||||||||||
Human   682 TLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLA 746

  Fly   714 YVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSVGEVMA 778
            ::|||:|||:|||:|||.|:|.|:|||||||||.|.|||||||.:|...|..|||||||||||||
Human   747 FIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMA 811

  Fly   779 IGRNFEEAFQKALRMVDSDVLGFDPDVVPLNKE-----QLAEQLSEPTDRRPFVIAAALQLGMSL 838
            |||.|||:|||||||....:.||.|. :|:|||     .|.::||||:..|.:.||.|:...|||
Human   812 IGRTFEESFQKALRMCHPSIEGFTPR-LPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSL 875

  Fly   839 RELHQLTNIDYWFLEKLERIILLQSLLT-RNGSRTDAALLLKAKRFGFSDKQIAKYIKSTELAVR 902
            .|:.:||.||.|||.|:..|:.::..|. .|........|.:||..|||||||:|.:..||...|
Human   876 DEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTR 940

  Fly   903 HQRQEFGIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDFPGGHTIVVGSGVYRIGSSVEFDW 967
            ..|.:..|.|.||||||:|.|:|:.|||||.||||.||||:|.....:|:|.|.|.|||||||||
Human   941 ELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDW 1005

  Fly   968 CAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILSMGGQ 1032
            |||..:|.||:|.:.|:::|.||||||||:|.||:|||||:|.|.::|||..|...|.|:|:|||
Human  1006 CAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQ 1070

  Fly  1033 LPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCEEVGY 1097
            :|||:|:.|::...|::||||..||.||:|..||.:||...:.|..||.:..|..|:||.:.|.|
Human  1071 IPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDY 1135

  Fly  1098 PCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVASDGRILC 1162
            |||:||||||||:||||.:|..:::.:|..|:.||:|||||::||:..|:|:::|||..|||::.
Human  1136 PCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVIS 1200

  Fly  1163 MAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAKNNELKVI 1227
            .|:|||||:||||||||||:.|.|.::...:|.:|..|..:|....::||||:|.:.|.|::.||
Human  1201 HAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVI 1265

  Fly  1228 ECNVRVSRSFPFVSKTLDHDFVATATRAIVGLDVE------------PLDVLHGVGKVGVKVPQF 1280
            |||:|.|||||||||||..||:..||:.::|.:|:            |.|.      |.:|.|.|
Human  1266 ECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADY------VAIKAPMF 1324

  Fly  1281 SFSRLAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSI-GSFKHKMELLP 1344
            |:.||..||..|..||||||||||||:..:.|:||||:||||:||:..:|:.| .||:.:  .|.
Human  1325 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR--FLG 1387

  Fly  1345 SIRDLAKMGYKLYASMGTGDFYAEHGVNVESVQWTFDKTTPDDINGELRHLAEFLANKQFDLVIN 1409
            ....|...|:||:|:..|.|:...:.|....|.|    .:.:..|..|..:.:.:.:...|||||
Human  1388 VAEQLHNEGFKLFATEATSDWLNANNVPATPVAW----PSQEGQNPSLSSIRKLIRDGSIDLVIN 1448

  Fly  1410 LPMSGGGARRVSSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMR 1456
            ||.:.      :.|:...|..||.|||..|||:|:.:.|||..|:::
Human  1449 LPNNN------TKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQ 1489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_001285343.1	CPSaseIIsmall	7..376	CDD:273580	172/372 (46%)
		CPSase_sm_chain	7..151	CDD:279346	66/146 (45%)
		GATase1_CPSase	196..371	CDD:153215	85/175 (49%)
		CPSaseII_lrg	403..1455	CDD:273581	573/1073 (53%)
		CPSase_L_D2	524..726	CDD:280881	130/201 (65%)
		CPSase_L_D3	815..935	CDD:280882	54/120 (45%)
		P-loop_NTPase	947..>1149	CDD:304359	106/201 (53%)
		ATP-grasp_4	1084..1265	CDD:302634	94/192 (49%)
		MGS_CPS_I_III	1327..1453	CDD:238711	38/126 (30%)
		CAD_DHOase	1475..1821	CDD:238641
		PLN02527	1918..2220	CDD:178142
		OTCace_N	1919..2060	CDD:280825
		OTCace	2067..2216	CDD:278609
CPS1	NP_001356185.1	CPSaseIIsmall	57..411	CDD:273580	172/372 (46%)
CPS1	NP_001356185.1	CPSaseII_lrg	430..1488	CDD:273581	574/1076 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55291
OrthoDB	1	1.010	-	-		D15670at33208
OrthoFinder	1	1.000	-	-		FOG0001016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100435
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1046
SonicParanoid	1	1.000	-	-		X1225
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860