DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment r and cps1

DIOPT Version :9

Sequence 1:	NP_001285343.1	Gene:	r / 32640	FlyBaseID:	FBgn0003189	Length:	2224	Species:	Drosophila melanogaster
Sequence 2:	XP_004917905.1	Gene:	cps1 / 100158506	XenbaseID:	XB-GENE-1010206	Length:	1494	Species:	Xenopus tropicalis

Alignment Length:	1487	Identity:	761/1487 - (51%)
Similarity:	1025/1487 - (68%)	Gaps:	87/1487 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNYG 72
            |.|||||.|.|||||:..|       ..|||||.||:.||.||:||..|.||||.||.|:|||.|
Frog    41 LVLEDGTKLKGYSFGHPTS-------VAGEVVFNTGLAGYVEAITDPGYRGQILTLTNPIIGNGG 98

  Fly    73 VPAPDE---DEHGLPLHFEWMKGV----VQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQ 130
              |||.   |.:||      ||.:    :|.:.|:|.:...|..|||..|:|.:||.:.|||.:.
Frog    99 --APDTKALDSYGL------MKFIESEHIQVSGLLVLDYTNEHSHWRAVKSLSEWLHEEKVPALC 155

  Fly   131 DIDTRALTKKLREQGSMLGKIVYEKPPVEGLPKSSFVDPNVRNLAKECSVKERQVYGNPNGKGPR 195
            .||||.|.||:|::|::||||.:|..|||      .||||.|||..|.|.||.:|||  .|...:
Frog   156 GIDTRMLAKKIRDKGTVLGKIEFEGKPVE------LVDPNKRNLIDEVSTKEIKVYG--KGNPVK 212

  Fly   196 IAILDCGLKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGPGNPESCDQIVQQVRKVIEE 260
            |..:|||:|.|.:|.|:||||.|:|:||:......::|.|||:|||||||....::|.:|||...
Frog   213 IVAVDCGVKHNTIRQLVQRGAEVSLVPWNHDFSKMEYDGLFLTNGPGNPELAQPLIQNLRKVFNS 277

  Fly   261 GQ-KPVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDLEQLPDG 324
            .: :||||:.:|:::.|.|.|..||::...|||.|.|.::...|:..:|:|||.|.||...||:|
Frog   278 DRPEPVFGVSMGNEIAALAAGARTYRLPMANRGQNQPVMNTMNGQAFITAQNHAYGVDSNSLPEG 342

  Fly   325 WSELFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQQ-KDLTIPQLIEQR 388
            |..||||.||.:||||:|.:||.|:.|||||...||.||||||||||..|:: |..|:..::.:
Frog   343 WKPLFVNINDHSNEGIMHETKPIFTAQFHPEGSPGPADTEFLFDVFMSMIKKGKGTTLASVMPK- 406

  Fly   389 LRPTTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIATVQTS 453
                 ||:.|..:...|||||||||||||||||||||||||:|||:|.|::|||:|||||:|||:
Frog   407 -----PALQSKRIEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTN 466

  Fly   454 K-GM--ADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVQLERAGVFSKYNVRILGTP 515
            : |:  ||..||||:||.:|.:|||:|||:|::|..||||||||||:|.:.||..:|.|::|||.
Frog   467 EIGLKQADSVYFLPVTPQFVTEVIKAERPDGIILGMGGQTALNCGVELFKRGVLKEYGVKVLGTS 531

  Fly   516 IQSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYPVMARAAFSLGGLGSGFANN 580
            ::||:.||||:||::::.||.|.:|||.||.::..|:|||.::|||||.|:|::|||||||...:
Frog   532 VESIMATEDRQLFSDKLMEINEPIAPSFAVETIKDAVDAADKIGYPVMIRSAYALGGLGSGLCPD 596

  Fly   581 EEELQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCITVCNMENFDPLGIHTGESIVVA 645
            :|.|..|..:|||.|:|::|::|:.||||:||||||||.:||:|||||||.|.:|:|||:|||||
Frog   597 KETLMDLGTKALAMSNQILVERSVVGWKEIEYEVVRDAADNCVTVCNMENMDAMGVHTGDSIVVA 661

  Fly   646 PSQTLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKATGY 710
            ||||||:.|:|||||.|:||:||.|:|||||||:||.|.|.:|.|||||||||||||||||||||
Frog   662 PSQTLSNEEFQMLRSCAIKVVRHLGIVGECNIQFALHPTSLEYVIIEVNARLSRSSALASKATGY 726

  Fly   711 PLAYVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSVGE 775
            |||::|||:|||:|||:|||.|:|.|||||||||||.|.|||||||.:|...|..||||||||||
Frog   727 PLAFIAAKIALGIPLPEIKNVVSGKTTACFEPSLDYMVTKIPRWDLDRFHGTSGVIGSSMKSVGE 791

  Fly   776 VMAIGRNFEEAFQKALRMVDSDVLGFDPDVVPLNKE-----QLAEQLSEPTDRRPFVIAAALQLG 835
            ||||||||||:|||||||....|.||..: :|:||.     .|.::::|||..|.:.:|..|:.|
Frog   792 VMAIGRNFEESFQKALRMCHPSVDGFTAN-LPMNKSWAADANLRKEMAEPTSTRVYSMAKGLETG 855

  Fly   836 MSLRELHQLTNIDYWFLEKLERIILLQSLL--TRNGSRTDAALLLKAKRFGFSDKQIAKYIKSTE 898
            :.:.|:|:||:||.|||.|::.|:.::..|  ||:.|..:.. |.:||:.||||:.|.|.:..:|
Frog   856 IHMDEIHKLTSIDKWFLHKMQGILNMEKTLRSTRSESVPEET-LRRAKQIGFSDRYIGKCLGLSE 919

  Fly   899 LAVRHQRQEFGIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDFPGGHTIVVGSGVYRIGSSV 963
            ...|..|....::|.||||||:|.|:||.|||||.||||.|||:.|.....:|:|.|.|.|||||
Frog   920 AQTRELRLNKNVKPWVKQIDTLAAEYPAITNYLYLTYNGQEHDIKFDDQGMMVLGCGPYHIGSSV 984

  Fly   964 EFDWCAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILS 1028
            |||||||..:|.||:|.:.|:::|.||||||||:|.||||||||:|.|.::|:::.|:.:|.|:|
Frog   985 EFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDRLYFEELSQERILDVFQQEHCDGCIIS 1049

  Fly  1029 MGGQLPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCE 1093
            :|||:|||:|:.|::...|::||||..||.||:|..||.:||...|.|..||.:.:|..|::|..
Frog  1050 VGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSTFSAILDELQIAQAPWKAVNSLDDALQFTN 1114

  Fly  1094 EVGYPCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVASDG 1158
            .||||||:||||||||:||||.:..::|:.:|..|:.||:||||||:||:..|:|:::||||.:|
Frog  1115 TVGYPCLLRPSYVLSGSAMNVVHGEEELKNFLAEATRVSQEHPVVITKFIQGAREVEMDAVAKEG 1179

  Fly  1159 RILCMAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAKNNE 1223
            |::|.|:|||||:||||||||||:.|.|.::...||.:|..|..:|:...::||||||.:.:.|:
Frog  1180 RVICHAISEHVEDAGVHSGDATLMIPTQTISQGALEKVKIATKKIANAFAISGPFNMQFLVRGND 1244

  Fly  1224 LKVIECNVRVSRSFPFVSKTLDHDFVATATRAIVGLDVE------------PLDVLHGVGKVGVK 1276
            :.|||||:|.|||||||||||..||:..||:.:.|..|:            |.|.      ||:|
Frog  1245 VLVIECNLRASRSFPFVSKTLGVDFIDVATKVMTGEKVDEAALPTLASPIIPADY------VGIK 1303

  Fly  1277 VPQFSFSRLAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSIGSFKHKME 1341
            .|.||:.||.|||..|..||||||||||||:|.|.|:||||:||||::|:..:|:.| ....:..
Frog  1304 APMFSWPRLRGADPVLRCEMASTGEVACFGENIYSAFLKAMISTGFKLPQKGILIGI-QHSFRPH 1367

  Fly  1342 LLPSIRDLAKMGYKLYASMGTGDFYAEHGVNVESVQWTFDK----TTPDDINGELRHLAEFLANK 1402
            .|.:.:.|.:.||||||:..|.|:...:.|....|.|...:    ::|.        :.:.:...
Frog  1368 FLGTAQQLKEEGYKLYATEATADWLNANDVPATHVAWPSQEGKSSSSPS--------IYKLIKEG 1424

  Fly  1403 QFDLVINLPMSGGGARRVSSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMRMNG 1459
            ..|:|||||.:.      :..:...|..||.|.|..|.|:|:.:..||..|:|:.:|
Frog  1425 NIDMVINLPNNN------TKHVRDNYLIRRTAADCGIALLTNFQVVKLFAEAMKYSG 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_001285343.1	CPSaseIIsmall	7..376	CDD:273580	182/375 (49%)
		CPSase_sm_chain	7..151	CDD:279346	71/149 (48%)
		GATase1_CPSase	196..371	CDD:153215	87/175 (50%)
		CPSaseII_lrg	403..1455	CDD:273581	572/1077 (53%)
		CPSase_L_D2	524..726	CDD:280881	132/201 (66%)
		CPSase_L_D3	815..935	CDD:280882	50/121 (41%)
		P-loop_NTPase	947..>1149	CDD:304359	107/201 (53%)
		ATP-grasp_4	1084..1265	CDD:302634	97/192 (51%)
		MGS_CPS_I_III	1327..1453	CDD:238711	32/129 (25%)
		CAD_DHOase	1475..1821	CDD:238641
		PLN02527	1918..2220	CDD:178142
		OTCace_N	1919..2060	CDD:280825
		OTCace	2067..2216	CDD:278609
cps1	XP_004917905.1	CPSaseIIsmall	39..394	CDD:273580	182/375 (49%)
cps1	XP_004917905.1	CPSaseII_lrg	411..1471	CDD:273581	573/1082 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55291
OrthoDB	1	1.010	-	-		D15670at33208
OrthoFinder	1	1.000	-	-		FOG0001016
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1046
SonicParanoid	1	1.000	-	-		X1225
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960