Protein Alignment r and cps1

DIOPT Version :10

• Sequence 1: NP_523377.1
• Gene: r / 32640
• FlyBaseID: FBgn0003189
• Length: 2224
• Species: Drosophila melanogaster
• Sequence 2: XP_004917905.1
• Gene: cps1 / 100158506
• XenbaseID: XB-GENE-1010206
• Length: 1494
• Species: Xenopus tropicalis
• Alignment Length: 1487
• Identity: 761/1487 - (51%)
• Similarity: 1025/1487 - (68%)
• Gaps: 87/1487 - (5%)

  Fly     8 LALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNYG 72
            |.|||||.|.|||||:..|       ..|||||.||:.||.||:||..|.||||.||.|:|||.|
 Frog    41 LVLEDGTKLKGYSFGHPTS-------VAGEVVFNTGLAGYVEAITDPGYRGQILTLTNPIIGNGG 98

  Fly    73 VPAPDE---DEHGLPLHFEWMKGV----VQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQ 130
              |||.   |.:||      ||.:    :|.:.|:|.:...|..|||..|:|.:||.:.|||.:.
 Frog    99 --APDTKALDSYGL------MKFIESEHIQVSGLLVLDYTNEHSHWRAVKSLSEWLHEEKVPALC 155

  Fly   131 DIDTRALTKKLREQGSMLGKIVYEKPPVEGLPKSSFVDPNVRNLAKECSVKERQVYGNPNGKGPR 195
            .||||.|.||:|::|::||||.:|..|||      .||||.|||..|.|.||.:|||  .|...:
 Frog   156 GIDTRMLAKKIRDKGTVLGKIEFEGKPVE------LVDPNKRNLIDEVSTKEIKVYG--KGNPVK 212

  Fly   196 IAILDCGLKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGPGNPESCDQIVQQVRKVIEE 260
            |..:|||:|.|.:|.|:||||.|:|:||:......::|.|||:|||||||....::|.:|||...
 Frog   213 IVAVDCGVKHNTIRQLVQRGAEVSLVPWNHDFSKMEYDGLFLTNGPGNPELAQPLIQNLRKVFNS 277

  Fly   261 GQ-KPVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDLEQLPDG 324
            .: :||||:.:|:::.|.|.|..||::...|||.|.|.::...|:..:|:|||.|.||...||:|
 Frog   278 DRPEPVFGVSMGNEIAALAAGARTYRLPMANRGQNQPVMNTMNGQAFITAQNHAYGVDSNSLPEG 342

  Fly   325 WSELFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQQ-KDLTIPQLIEQR 388
            |..||||.||.:||||:|.:||.|:.|||||...||.||||||||||..|:: |..|:..::.:
 Frog   343 WKPLFVNINDHSNEGIMHETKPIFTAQFHPEGSPGPADTEFLFDVFMSMIKKGKGTTLASVMPK- 406

  Fly   389 LRPTTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIATVQTS 453
                 ||:.|..:...|||||||||||||||||||||||||:|||:|.|::|||:|||||:|||:
 Frog   407 -----PALQSKRIEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTN 466

  Fly   454 K-GM--ADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVQLERAGVFSKYNVRILGTP 515
            : |:  ||..||||:||.:|.:|||:|||:|::|..||||||||||:|.:.||..:|.|::|||.
 Frog   467 EIGLKQADSVYFLPVTPQFVTEVIKAERPDGIILGMGGQTALNCGVELFKRGVLKEYGVKVLGTS 531

  Fly   516 IQSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYPVMARAAFSLGGLGSGFANN 580
            ::||:.||||:||::::.||.|.:|||.||.::..|:|||.::|||||.|:|::|||||||...:
 Frog   532 VESIMATEDRQLFSDKLMEINEPIAPSFAVETIKDAVDAADKIGYPVMIRSAYALGGLGSGLCPD 596

  Fly   581 EEELQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCITVCNMENFDPLGIHTGESIVVA 645
            :|.|..|..:|||.|:|::|::|:.||||:||||||||.:||:|||||||.|.:|:|||:|||||
 Frog   597 KETLMDLGTKALAMSNQILVERSVVGWKEIEYEVVRDAADNCVTVCNMENMDAMGVHTGDSIVVA 661

  Fly   646 PSQTLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKATGY 710
            ||||||:.|:|||||.|:||:||.|:|||||||:||.|.|.:|.|||||||||||||||||||||
 Frog   662 PSQTLSNEEFQMLRSCAIKVVRHLGIVGECNIQFALHPTSLEYVIIEVNARLSRSSALASKATGY 726

  Fly   711 PLAYVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSVGE 775
            |||::|||:|||:|||:|||.|:|.|||||||||||.|.|||||||.:|...|..||||||||||
 Frog   727 PLAFIAAKIALGIPLPEIKNVVSGKTTACFEPSLDYMVTKIPRWDLDRFHGTSGVIGSSMKSVGE 791

  Fly   776 VMAIGRNFEEAFQKALRMVDSDVLGFDPDVVPLNKE-----QLAEQLSEPTDRRPFVIAAALQLG 835
            ||||||||||:|||||||....|.||..: :|:||.     .|.::::|||..|.:.:|..|:.|
 Frog   792 VMAIGRNFEESFQKALRMCHPSVDGFTAN-LPMNKSWAADANLRKEMAEPTSTRVYSMAKGLETG 855

  Fly   836 MSLRELHQLTNIDYWFLEKLERIILLQSLL--TRNGSRTDAALLLKAKRFGFSDKQIAKYIKSTE 898
            :.:.|:|:||:||.|||.|::.|:.::..|  ||:.|..:.. |.:||:.||||:.|.|.:..:|
 Frog   856 IHMDEIHKLTSIDKWFLHKMQGILNMEKTLRSTRSESVPEET-LRRAKQIGFSDRYIGKCLGLSE 919

  Fly   899 LAVRHQRQEFGIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDFPGGHTIVVGSGVYRIGSSV 963
            ...|..|....::|.||||||:|.|:||.|||||.||||.|||:.|.....:|:|.|.|.|||||
 Frog   920 AQTRELRLNKNVKPWVKQIDTLAAEYPAITNYLYLTYNGQEHDIKFDDQGMMVLGCGPYHIGSSV 984

  Fly   964 EFDWCAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILS 1028
            |||||||..:|.||:|.:.|:::|.||||||||:|.||||||||:|.|.::|:::.|:.:|.|:|
 Frog   985 EFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDRLYFEELSQERILDVFQQEHCDGCIIS 1049

  Fly  1029 MGGQLPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCE 1093
            :|||:|||:|:.|::...|::||||..||.||:|..||.:||...|.|..||.:.:|..|::|..
 Frog  1050 VGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSTFSAILDELQIAQAPWKAVNSLDDALQFTN 1114

  Fly  1094 EVGYPCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVASDG 1158
            .||||||:||||||||:||||.:..::|:.:|..|:.||:||||||:||:..|:|:::||||.:|
 Frog  1115 TVGYPCLLRPSYVLSGSAMNVVHGEEELKNFLAEATRVSQEHPVVITKFIQGAREVEMDAVAKEG 1179

  Fly  1159 RILCMAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAKNNE 1223
            |::|.|:|||||:||||||||||:.|.|.::...||.:|..|..:|:...::||||||.:.:.|:
 Frog  1180 RVICHAISEHVEDAGVHSGDATLMIPTQTISQGALEKVKIATKKIANAFAISGPFNMQFLVRGND 1244

  Fly  1224 LKVIECNVRVSRSFPFVSKTLDHDFVATATRAIVGLDVE------------PLDVLHGVGKVGVK 1276
            :.|||||:|.|||||||||||..||:..||:.:.|..|:            |.|.      ||:|
 Frog  1245 VLVIECNLRASRSFPFVSKTLGVDFIDVATKVMTGEKVDEAALPTLASPIIPADY------VGIK 1303

  Fly  1277 VPQFSFSRLAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSIGSFKHKME 1341
            .|.||:.||.|||..|..||||||||||||:|.|.|:||||:||||::|:..:|:.| ....:..
 Frog  1304 APMFSWPRLRGADPVLRCEMASTGEVACFGENIYSAFLKAMISTGFKLPQKGILIGI-QHSFRPH 1367

  Fly  1342 LLPSIRDLAKMGYKLYASMGTGDFYAEHGVNVESVQWTFDK----TTPDDINGELRHLAEFLANK 1402
            .|.:.:.|.:.||||||:..|.|:...:.|....|.|...:    ::|.        :.:.:...
 Frog  1368 FLGTAQQLKEEGYKLYATEATADWLNANDVPATHVAWPSQEGKSSSSPS--------IYKLIKEG 1424

  Fly  1403 QFDLVINLPMSGGGARRVSSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMRMNG 1459
            ..|:|||||.:.      :..:...|..||.|.|..|.|:|:.:..||..|:|:.:|
 Frog  1425 NIDMVINLPNNN------TKHVRDNYLIRRTAADCGIALLTNFQVVKLFAEAMKYSG 1475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_523377.1	CPSaseIIsmall	7..376	CDD:273580	182/375 (49%)
		CPSaseII_lrg	403..1455	CDD:273581	572/1077 (53%)
		CAD_DHOase	1475..1821	CDD:238641
		PyrB	1913..2221	CDD:440306
cps1	XP_004917905.1	CPSaseIIsmall	39..394	CDD:273580	182/375 (49%)
		CPSaseII_lrg	411..1471	CDD:273581	573/1082 (53%)