Protein Alignment Nemp and Nemp1

DIOPT Version :10

• Sequence 1: NP_573142.1
• Gene: Nemp / 32639
• FlyBaseID: FBgn0030768
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_001106682.1
• Gene: Nemp1 / 210035
• MGIID: 2446113
• Length: 437
• Species: Mus musculus
• Alignment Length: 426
• Identity: 122/426 - (28%)
• Similarity: 207/426 - (48%)
• Gaps: 59/426 - (13%)

  Fly     7 LMLTVAGYFTSGIPGNTASSDVAYLTPGTYINLSENILGLQTLRTFCYPGKRLTVSSLFET-VEF 70
            |:|.|||....|      |:||      ..:.|.|:.:.:.:.:.|||  |.:.:....:. ...
Mouse    31 LLLVVAGCVVCG------SADV------NVVMLQESQVDMNSSQQFCY--KNVLIPKWHDIWTRI 81

  Fly    71 VLAIGSDDYSQYGGKTPEEVLQH-------------YKDK--QSLFSITLFAQKRQLLQLSPFEQ 120
            .:.:.|....:......||.|:.             .|:|  .:..::.|::.| ..|::...|:
Mouse    82 QVRVNSSKLVRVTQVDNEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTK-TCLKVEMIEK 145

  Fly   121 QCIGISSRQAYTVILNSIPLDLWRLAQFAVGILILFSARRLAKNSVFYYLVGIVIGICASLLVVI 185
            .       ..|:|.:.. ..|......|.:|:.:.|....|:::.:|||..|:.:||.||||:||
Mouse   146 D-------TTYSVTVTR-RFDPKLFLVFLLGLTLFFCGDLLSRSQIFYYSTGMSVGIVASLLIVI 202

  Fly   186 YLAAKLFPRRTMMYGVLIGGWTIGFYVIKQLADNLRLILITYRDHVLGYLVITGLISFLICYRIG 250
            ::.:|..|:|:.:|.:|:|||:...|:|:.:..||:.|..:|..::|.|::..|.:||.:||:.|
Mouse   203 FMISKFMPKRSPIYVILVGGWSFSLYLIQLVFKNLQEIWRSYWHYLLSYILTVGFMSFAVCYKYG 267

  Fly   251 PPKNPRSQTIVMWVLQAIGAVMAYFSSW--HTSAVIFIMVLVFVAHYFPISWTNQIKFMYRRRF- 312
            |.:|.||..::.|.||.:|..:.|.|..  |.:..:.::.|......:||.|   :...|||..
Mouse   268 PLENERSINLLTWTLQLLGLGLMYSSIQIPHVAFALIVIALCTKNLEYPIHW---LCSTYRRMCK 329

  Fly   313 ----PLKRRMLTQEEYEQQTAVETSKSLADLRKYVNSPECKQWAVMGKLRDPLRFASFANGAPHL 373
                |:..|:||:|||..|..|||.|:|.:||::.|||||..|..:.:::.|.|||.|..|:.||
Mouse   330 ASGKPVPPRLLTEEEYRIQGEVETQKALQELREFCNSPECSAWKTISRIQSPKRFADFVEGSFHL 394

  Fly   374 DDEEIEDHSR--------TIEESMDAAPEEESVEEP 401
            ...|:..|.:        |.:|.:.:  |||..|.|
Mouse   395 TPNEVSVHEQEYGLGSIFTQDEELSS--EEEGSEYP 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nemp	NP_573142.1	NEMP	132..375	CDD:463008	87/249 (35%)
Nemp1	NP_001106682.1	NEMP	150..396	CDD:463008	87/249 (35%)
		A, required for its colocalization with lamins at the nuclear envelope. /evidence=ECO:0000269|PubMed:25946333	184..295		44/110 (40%)
		Required for nuclear localization. /evidence=ECO:0000269|PubMed:25946333	334..437		38/97 (39%)
		B, required for interaction with RAN-GTP. /evidence=ECO:0000269|PubMed:25946333	334..403		30/68 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..437		6/16 (38%)