Protein Alignment mthl1 and ADGRE5

DIOPT Version :9

• Sequence 1: NP_001285340.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_510966.1
• Gene: ADGRE5 / 976
• HGNCID: 1711
• Length: 835
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 131/611 - (21%)
• Similarity: 224/611 - (36%)
• Gaps: 155/611 - (25%)

  Fly    79 EALWLPMVYLVQQQRFFEPHGASPRFLKFLPNTRPTCRKDQTTEIFRSRGANVMLFPNGTLYVRE 143
            |||..|:.:|:..|.............|.||....|......||:              ||.::|
Human   316 EALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTEL--------------TLMIQE 366

  Fly   144 R----ALMVQPSDYC-VDWEVAVVCLNDSQPINALEDPDYAANPLVQQEP-----PKASLRL-SK 197
            |    ..|.|.|... ::|.||.          ..|||..|...::..:.     ..|||.| ||
Human   367 RGDKNVTMGQSSARMKLNWAVAA----------GAEDPGPAVAGILSIQNMTTLLANASLNLHSK 421

  Fly   198 CCGKWGSYNTQLQNCDLQPNHQAAVDG--LLRLSPQLPEGSYQTSYGLPDCGQPGGYSIAG-DWQ 259
                        :..:|:..:::::.|  |.|||  .....:.:.....:...|..::.:. :..
Human   422 ------------KQAELEEIYESSIRGVQLRRLS--AVNSIFLSHNNTKELNSPILFAFSHLESS 472

  Fly   260 DAKLDRNTAMLQLPHKNLSAG-------QYCLEHTQREGEVKIIACQHLFS---SAAGAGIHDGS 314
            |.:..|:.     |.|::..|       .:....:.|.|......||.|.|   |......|..|
Human   473 DGEAGRDP-----PAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSS 532

  Fly   315 IGGTIEQANGQNLQKAVLTGGILVSIVFLSATLVAGFLL--------PAVHHALHWRCQICYVTC 371
            ....:...:.::.:..::|...|...:|.....:..|||        ..:|  ||    :|  .|
Human   533 FAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIH--LH----LC--IC 589

  Fly   372 LLFGK--ILLAIEELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWW-TFRDFRPSSLE 433
            |..|.  .|..||.....:   ...|..:|..:.:.|||||.|::.....::: ..|.|:...|.
Human   590 LFVGSTIFLAGIENEGGQV---GLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLS 651

  Fly   434 RNQEALRRYLYSLYAWGGPLLITFVAACVDQLPETTLLRPGFGQ-LYCWFDNRNLSIFAYFYGPI 497
                  .|:| .|..:|.||||..|:|.:        ...|:|: .|||.|.....::: |.||:
Human   652 ------TRWL-CLIGYGVPLLIVGVSAAI--------YSKGYGRPRYCWLDFEQGFLWS-FLGPV 700

  Fly   498 GLLLCANIALFVSTTHQLTCGLWK-RDDVKSSSEKSALGRVCLKLVVVMGVTWIADILSWLVGGP 561
            ..::..|..:||:|..:||....: ..|:|...:..||....:..:.::|.||:
Human   701 TFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWV----------- 754

  Fly   562 HGVWFFTD----------LINALQGVFIFIVVGC--QPQVWTACRRIFCPRLRHDITNTTNGVQH 614
            .|::.|.|          ::|.|||.|::: :.|  ..:|....|:..|
Human   755 FGLFIFDDRSLVLTYVFTILNCLQGAFLYL-LHCLLNKKVREEYRKWAC---------------- 802

  Fly   615 SSSSQGLPSMAGGTEITQNTTTTTTT 640
                    .:|||::.::.|:||:.|
Human   803 --------LVAGGSKYSEFTSTTSGT 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	66/272 (24%)
ADGRE5	NP_510966.1	EGF_CA	64..99	CDD:284955
		EGF_CA	116..>148	CDD:214542
		EGF_CA	160..207	CDD:284955
		EGF_CA	209..243	CDD:284955
		GPS	493..536	CDD:280071	9/42 (21%)
		7tm_2	544..782	CDD:278432	66/275 (24%)
		ProP	608..>785	CDD:223553	51/207 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	814..835		4/7 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810