DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and ADGRE3

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_115960.2	Gene:	ADGRE3 / 84658	HGNCID:	23647	Length:	652	Species:	Homo sapiens

Alignment Length:	690	Identity:	135/690 - (19%)
Similarity:	237/690 - (34%)	Gaps:	202/690 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SPPPTV--KLNKCCHSGEYLNDGTCIAGSEALWLPMVYLVQQQRFFEPHGASPRFLKFLPNTRPT 114
            :||.:|  ..|..|::.|......|:.|                 :..|..:.:|.....||...
Human    72 TPPYSVYCGFNAVCYNVEGSFYCQCVPG-----------------YRLHSGNEQFSNSNENTCQD 119

  Fly   115 CRKDQTTE----------IFRSRGANVMLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLNDSQP 169
            ....:|||          .|.|      |..|.||:..|....:.        ..|...|.|.:.
Human   120 TTSSKTTEGRKELQKIVDKFES------LLTNQTLWRTEGRQEIS--------STATTILRDVES 170

  Fly   170 ---INALEDPDYAANPLVQQEPPKASLRLSKCCG---KWGSYNTQLQNCDLQPNHQAAVDGLLRL 228
               ..||:||:.....:........:..::..|.   |..:.|.|:.:.|::      ...:::.
Human   171 KVLETALKDPEQKVLKIQNDSVAIETQAITDNCSEERKTFNLNVQMNSMDIR------CSDIIQG 229

  Fly   229 SPQLPEGSYQTSYGLPDCGQPGGYSIAGDWQDA----KLDR------NTAMLQL---PHKNLSAG 280
            ..|.|......|           ||..|:..:|    ::|:      |:.::..   |.:|:|..
Human   230 DTQGPSAIAFIS-----------YSSLGNIINATFFEEMDKKDQVYLNSQVVSAAIGPKRNVSLS 283

  Fly   281 Q---YCLEHTQREGEVKIIACQHLFSSAAGA-GIHDG----SIGGTIEQANGQNLQK-AVLTG-- 334
            :   ...:|.:.....|.:.|.:..|:..|: ...||    .:..:....|..:|.. |||..
Human   284 KSVTLTFQHVKMTPSTKKVFCVYWKSTGQGSQWSRDGCFLIHVNKSHTMCNCSHLSSFAVLMALT 348

  Fly   335 --------------GILVSIVFLSATLVAGFLLPAVHH---ALHWRCQIC-YVTCLLFGKILLAI 381
                          |:.||::.|....:...|..|:.:   :||.:..:| ::..|||   |:.|
Human   349 SQEEDPVLTVITYVGLSVSLLCLLLAALTFLLCKAIRNTSTSLHLQLSLCLFLAHLLF---LVGI 410

  Fly   382 EELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDF---RPSSLERNQEALRRYL 443
            :.....:     .|..:|..:.:.:||||.|:.....:::.|.|:.   ..||:.|    |.:::
Human   411 DRTEPKV-----LCSIIAGALHYLYLAAFTWMLLEGVHLFLTARNLTVVNYSSINR----LMKWI 466

  Fly   444 YSLYAWGGPLLITFVAACVDQLPETTLLRPGFGQLY-----CWFDNRNLSIFAYFYGPIGLLLCA 503
            .....:|.|.:...::|.            .:..||     ||. :.:......|.||:..:..|
Human   467 MFPVGYGVPAVTVAISAA------------SWPHLYGTADRCWL-HLDQGFMWSFLGPVCAIFSA 518

  Fly   504 NIALFVSTTHQLTCGLWKRDDVKSSSEKSALGRV------CLKLVVVMGVTWIADILSWLVGGPH 562
            |:.||:     |...:.||.....:||.|.:...      ....:.::|.||   .|..|..||.
Human   519 NLVLFI-----LVFWILKRKLSSLNSEVSTIQNTRMLAFKATAQLFILGCTW---CLGLLQVGPA 575

  Fly   563 G---VWFFTDLINALQGVFIFIV-------VGCQPQVWTACRRIFCPRLRHDITNTTNGVQHSSS 617
            .   .:.|| :||:|||.|||:|       |..|.|.|.
Human   576 AQVMAYLFT-IINSLQGFFIFLVYCLLSQQVQKQYQKWF-------------------------- 613

  Fly   618 SQGLPSMAGGTEITQNTTTTTTTTNTTATHMPSNPAEDEV 657
                      .||.::.:.:.|.|.::.....|.|:|.:|
Human   614 ----------REIVKSKSESETYTLSSKMGPDSKPSEGDV 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	64/287 (22%)
ADGRE3	NP_115960.2	EGF_CA	67..104	CDD:238011	8/48 (17%)
		GPS	304..344	CDD:280071	8/39 (21%)
		7tm_4	353..594	CDD:304433	61/274 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810