Protein Alignment mthl1 and ADGRE3

DIOPT Version :10

• Sequence 1: NP_573140.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_115960.2
• Gene: ADGRE3 / 84658
• HGNCID: 23647
• Length: 652
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 135/690 - (19%)
• Similarity: 237/690 - (34%)
• Gaps: 202/690 - (29%)

  Fly    52 SPPPTV--KLNKCCHSGEYLNDGTCIAGSEALWLPMVYLVQQQRFFEPHGASPRFLKFLPNTRPT 114
            :||.:|  ..|..|::.|......|:.|                 :..|..:.:|.....||...
Human    72 TPPYSVYCGFNAVCYNVEGSFYCQCVPG-----------------YRLHSGNEQFSNSNENTCQD 119

  Fly   115 CRKDQTTE----------IFRSRGANVMLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLNDSQP 169
            ....:|||          .|.|      |..|.||:..|....:.        ..|...|.|.:.
Human   120 TTSSKTTEGRKELQKIVDKFES------LLTNQTLWRTEGRQEIS--------STATTILRDVES 170

  Fly   170 ---INALEDPDYAANPLVQQEPPKASLRLSKCCG---KWGSYNTQLQNCDLQPNHQAAVDGLLRL 228
               ..||:||:.....:........:..::..|.   |..:.|.|:.:.|::      ...:::.
Human   171 KVLETALKDPEQKVLKIQNDSVAIETQAITDNCSEERKTFNLNVQMNSMDIR------CSDIIQG 229

  Fly   229 SPQLPEGSYQTSYGLPDCGQPGGYSIAGDWQDA----KLDR------NTAMLQL---PHKNLSAG 280
            ..|.|......|           ||..|:..:|    ::|:      |:.::..   |.:|:|..
Human   230 DTQGPSAIAFIS-----------YSSLGNIINATFFEEMDKKDQVYLNSQVVSAAIGPKRNVSLS 283

  Fly   281 Q---YCLEHTQREGEVKIIACQHLFSSAAGA-GIHDG----SIGGTIEQANGQNLQK-AVLTG-- 334
            :   ...:|.:.....|.:.|.:..|:..|: ...||    .:..:....|..:|.. |||..
Human   284 KSVTLTFQHVKMTPSTKKVFCVYWKSTGQGSQWSRDGCFLIHVNKSHTMCNCSHLSSFAVLMALT 348

  Fly   335 --------------GILVSIVFLSATLVAGFLLPAVHH---ALHWRCQIC-YVTCLLFGKILLAI 381
                          |:.||::.|....:...|..|:.:   :||.:..:| ::..|||   |:.|
Human   349 SQEEDPVLTVITYVGLSVSLLCLLLAALTFLLCKAIRNTSTSLHLQLSLCLFLAHLLF---LVGI 410

  Fly   382 EELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDF---RPSSLERNQEALRRYL 443
            :.....:     .|..:|..:.:.:||||.|:.....:::.|.|:.   ..||:.|    |.:::
Human   411 DRTEPKV-----LCSIIAGALHYLYLAAFTWMLLEGVHLFLTARNLTVVNYSSINR----LMKWI 466

  Fly   444 YSLYAWGGPLLITFVAACVDQLPETTLLRPGFGQLY-----CWFDNRNLSIFAYFYGPIGLLLCA 503
            .....:|.|.:...::|.            .:..||     ||. :.:......|.||:..:..|
Human   467 MFPVGYGVPAVTVAISAA------------SWPHLYGTADRCWL-HLDQGFMWSFLGPVCAIFSA 518

  Fly   504 NIALFVSTTHQLTCGLWKRDDVKSSSEKSALGRV------CLKLVVVMGVTWIADILSWLVGGPH 562
            |:.||:     |...:.||.....:||.|.:...      ....:.::|.||   .|..|..||.
Human   519 NLVLFI-----LVFWILKRKLSSLNSEVSTIQNTRMLAFKATAQLFILGCTW---CLGLLQVGPA 575

  Fly   563 G---VWFFTDLINALQGVFIFIV-------VGCQPQVWTACRRIFCPRLRHDITNTTNGVQHSSS 617
            .   .:.|| :||:|||.|||:|       |..|.|.|.
Human   576 AQVMAYLFT-IINSLQGFFIFLVYCLLSQQVQKQYQKWF-------------------------- 613

  Fly   618 SQGLPSMAGGTEITQNTTTTTTTTNTTATHMPSNPAEDEV 657
                      .||.::.:.:.|.|.::.....|.|:|.:|
Human   614 ----------REIVKSKSESETYTLSSKMGPDSKPSEGDV 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_573140.1	7tmB3_Methuselah-like	326..598	CDD:410632	73/316 (23%)
		TM helix 1	327..352	CDD:410632	8/41 (20%)
		TM helix 2	362..384	CDD:410632	6/22 (27%)
		TM helix 3	396..423	CDD:410632	6/26 (23%)
		TM helix 4	441..461	CDD:410632	2/19 (11%)
		TM helix 5	485..515	CDD:410632	7/29 (24%)
		TM helix 6	530..557	CDD:410632	6/32 (19%)
		TM helix 7	562..587	CDD:410632	12/34 (35%)
ADGRE3	NP_115960.2	EGF_CA	67..104	CDD:238011	8/48 (17%)
		GPS	304..344	CDD:460350	8/39 (21%)
		7tm_GPCRs	353..614	CDD:475119	69/330 (21%)
		TM helix 1	356..380	CDD:410628	4/23 (17%)
		TM helix 2	389..410	CDD:410628	7/23 (30%)
		TM helix 3	420..442	CDD:410628	6/21 (29%)
		TM helix 4	466..482	CDD:410628	2/15 (13%)
		TM helix 5	501..524	CDD:410628	6/22 (27%)
		TM helix 6	551..573	CDD:410628	5/24 (21%)
		TM helix 7	577..602	CDD:410628	11/25 (44%)