DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl1 and adgrg4a

DIOPT Version :9

Sequence 1:NP_001285340.1 Gene:mthl1 / 32637 FlyBaseID:FBgn0030766 Length:676 Species:Drosophila melanogaster
Sequence 2:XP_021336868.1 Gene:adgrg4a / 793963 ZFINID:ZDB-GENE-121129-2 Length:1201 Species:Danio rerio


Alignment Length:351 Identity:78/351 - (22%)
Similarity:135/351 - (38%) Gaps:67/351 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   335 GILVSIVFLSATLVAGFLLPAVHHALHWRCQICYVTCLLFGKILLAIEELSSSLQPGSAACHTLA 399
            |..:|.:||..||:.......:......:..|.....||...:|..:....:|.. .:|.|.|:|
Zfish   881 GCGISSIFLGVTLLTYLAFEKLRRDYPSKILINLCMALLGLNMLFLVNSWFASFN-SNALCITVA 944

  Fly   400 ITMQFFFLAAFFWLNTMCFNIWW----TFRDFRPSSLERNQEALRRYLYSLYAWGGPLLITFVAA 460
            ....:||||.|.|:.....|::.    .|..:.||.:.:         :....||.||.:..:..
Zfish   945 AFQHYFFLATFTWMGLGAINMYLALVKVFNSYVPSYILK---------FCAVGWGIPLSVVILVL 1000

  Fly   461 CV-----------DQLPETTLLRPGFGQLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVST--- 511
            .:           |.|.|:|        .:|||.| :::.:........|::..||.:||..   
Zfish  1001 AIDFNSYGTSLSTDLLQEST--------AFCWFKN-DVTFYVTVVSFAILIMVCNIIVFVVVLVQ 1056

  Fly   512 THQLTCGLWKRDDVKSSSEKSALG--RVCLKLVVVMGVTWIADILSWLVGGP--HGVWFFTDLIN 572
            .|::      |.:..|||.|..|.  ||...|..::|:|||.....|   ||  ..:.:...::|
Zfish  1057 IHKM------RVNKPSSSRKGFLHDLRVVASLTFLLGLTWILVFFGW---GPAKTPLMYLFSILN 1112

  Fly   573 ALQGVFIFIVVGCQP----QVWTACRRIFCPRLRHDITNTTNGVQHSSSSQGLP---SMAGGTEI 630
            :|||.|||:......    :.|.  ..:.|.|.|..        ::|..|:.:|   ...||.::
Zfish  1113 SLQGFFIFLFYCLMKDNVRKQWR--MHLCCGRFRES--------EYSDWSRSVPKGDKGKGGLQV 1167

  Fly   631 TQNTTTTTTTTNTTATHMPSNPAEDE 656
            :.:..:..|:....:....:..:.||
Zfish  1168 SSSMKSEITSERKISDTSNTGTSNDE 1193

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl1NP_001285340.1 7tm_4 329..579 CDD:304433 63/265 (24%)
adgrg4aXP_021336868.1 LamG 50..210 CDD:328935
HsdR <637..>729 CDD:333053
GPS 815..858 CDD:307782
7tmB2_GPR112 871..1138 CDD:320663 67/286 (23%)
TM helix 1 873..898 CDD:320663 6/16 (38%)
TM helix 2 908..930 CDD:320663 4/21 (19%)
TM helix 3 941..968 CDD:320663 9/26 (35%)
TM helix 4 983..999 CDD:320663 4/24 (17%)
TM helix 5 1028..1051 CDD:320663 3/22 (14%)
TM helix 6 1073..1098 CDD:320663 9/27 (33%)
TM helix 7 1102..1127 CDD:320663 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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