Protein Alignment mthl1 and Adgrf4

DIOPT Version :9

• Sequence 1: NP_001285340.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_001276428.1
• Gene: Adgrf4 / 78249
• MGIID: 1925499
• Length: 698
• Species: Mus musculus
• Alignment Length: 497
• Identity: 107/497 - (21%)
• Similarity: 167/497 - (33%)
• Gaps: 156/497 - (31%)

  Fly   143 ERALMVQPSDYCVDWEVAVVCLNDSQPINALEDPDYAANPLVQQEPPKASLRLSKCCGKWGSYNT 207
            |.:|.:....|....:|.||.   ..|..||::..:.|:..:....|.....|.:.    ...||
Mouse   257 EHSLSLSVPRYNATEDVLVVI---EIPRQALQELSFNASQAIVVAFPTLGAILKEV----HRPNT 314

  Fly   208 QLQNCDLQPNHQAAVDGLLRLSPQLPEG-------------SYQTSYGLPDCGQPGGYSIAGDWQ 259
            .||.         .:|.|: ||..||||             |..||            |....|.
Mouse   315 NLQK---------PIDDLI-LSLVLPEGLNEIILTFDKINKSQSTS------------SQCVSWD 357

  Fly   260 DAKLDRNTAMLQLPHKNLSAGQY----CLEHTQREGEVKIIACQHLFSSAAGAGIHDGSIGGTIE 320
            .|                 .||:    |...:.....|| ..|:|
Mouse   358 PA-----------------TGQWDESPCTVMSDINSTVK-CRCRH-------------------- 384

  Fly   321 QANGQNLQKAVLTGGILVS-----------IVFLSATL-VAGFLLPAVHHALHWR---------- 363
                   .|||.:..||:|           |.|:..:: :...:|..|..|:.|.
Mouse   385 -------TKAVTSFSILMSSKPVKNTILNHITFIGLSISIFSLVLCLVIEAIVWSRVVVTEISYM 442

  Fly   364 ---CQICYVTCLLFGKILLAI-EELSSSLQPGSAACHTLAITMQFFFLAAFFWL----NTMCFNI 420
               |.:.....||...:...| ...|:::|.....|..:.....||||:.|||:    ..:.:.|
Mouse   443 RHVCIVNIAVSLLTANVWFIIGSNFSANVQEDHKWCVAVTFLCHFFFLSLFFWMLFKALLIVYGI 507

  Fly   421 WWTFRDFRPSSLERNQEALRRYLYSLYAWGGPLLITFVAACVDQLPETTLLRPGFGQL---YCWF 482
            ...||....|.:.....|:        .:|.||:|..:.        .|:..||.|..   .||.
Mouse   508 LVVFRRMMKSRMMAIGFAI--------GYGCPLVIAVIT--------VTVTEPGEGYTRKDACWL 556

  Fly   483 D-NRNLSIFAYFYGPIGLL---LCANIALFVSTTHQLTCGLWKRDD---VKSSSEKSALGRVCLK 540
            : |:..::||:....:.::   |...:|:.::|...| .|..|..|   |...|:..|:
Mouse   557 NWNQTKALFAFAIPALAIVAVNLLVVLAVAINTQRPL-IGSSKSQDMAIVFRISKNVAI------ 614

  Fly   541 LVVVMGVTWIADILSWLVGGPHGVW-FFTDLINALQGVFIFI 581
            |..::|:|| ...|:.|:.|.|.|: ....|:||.||.||.:
Mouse   615 LTPLLGLTW-GFGLTTLLEGVHLVFHIIFALLNAFQGFFILL 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	68/290 (23%)
Adgrf4	NP_001276428.1	GPS	351..394	CDD:366827	13/87 (15%)
		7tm_GPCRs	402..669	CDD:391938	64/278 (23%)
		TM helix 1	405..429	CDD:341315	4/23 (17%)
		TM helix 2	444..465	CDD:341315	4/20 (20%)
		TM helix 3	479..501	CDD:341315	7/21 (33%)
		TM helix 4	522..538	CDD:341315	5/23 (22%)
		TM helix 5	560..583	CDD:341315	3/22 (14%)
		TM helix 6	606..631	CDD:341315	7/31 (23%)
		TM helix 7	636..661	CDD:341315	8/20 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810