Protein Alignment mthl1 and Adgrf1

DIOPT Version :9

• Sequence 1: NP_001285340.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: XP_006525183.1
• Gene: Adgrf1 / 77596
• MGIID: 1924846
• Length: 927
• Species: Mus musculus
• Alignment Length: 561
• Identity: 118/561 - (21%)
• Similarity: 208/561 - (37%)
• Gaps: 180/561 - (32%)

  Fly   128 GANVMLFPN-------GTLYVRERALM--VQPSDYCVD------WEVAVVCLND--SQPINALED 175
            |:.|.|..|       .:|.|....||  :..:|:.:|      |.:.:....|  ||.:..||
Mouse   364 GSVVSLLSNISSLSLANSLTVSNLTLMNVINIADHILDSASITNWTILLQDAKDASSQLLKTLE- 427

  Fly   176 PDYAANPLVQQEPPKASLRLSKCCGK---W-GSYNTQLQN-------CDLQPNHQAAVDGLLRLS 229
               :.:.|:    |..:|.|: ..||   | |:..||:|:       .:::.|....:.|.:.:.
Mouse   428 ---SISSLI----PSMALPLN-FSGKFIDWKGTPVTQIQSTRGYNYQMEMRQNASLPIRGHVFIE 484

  Fly   230 PQLPEGSY--------QTSYG--LPDCGQPG--------------GYSIA----------GD--- 257
            |...:.|:        ..::|  || ..|.|              .|||:          |:
Mouse   485 PDQFQKSHPKTIISMASLTFGDILP-ITQRGNAWVNGPVISTLIQNYSISEIFLNFSKIKGNLTQ 548

  Fly   258 -----WQDAKLDRNTAMLQLPHKNLSAGQYCLEHTQREGEVKIIACQHLFSSAAGAGIHDGSIGG 317
                 |..::|..:.|..||.::.|              :..:..|.||.|.:.
Mouse   549 PRCVFWDFSQLQWSNAGCQLVNETL--------------DTVLCRCSHLTSFSM----------- 588

  Fly   318 TIEQANGQNLQKAVLTGGIL-----VSIVFLSATLVAGFLLPAVHHALHW----RCQICYV--TC 371
                     |....:...::     ::.:.||.: :|..:|..:..:|.|    |.|..|.  .|
Mouse   589 ---------LMSPFVPSSVVPVVKWITYIGLSIS-IASLILCLIIESLFWKQTKRSQTSYTRNIC 643

  Fly   372 LLFGKILLAIEE----LSSSLQPG---SAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRP 429
            |:...:.|.|.:    :::::.|.   |..|........||:||.|||:  :...|...:|..
Mouse   644 LVNIAVSLLIADVWFIIAATVDPSVSPSGVCVAAVFFTHFFYLAVFFWM--LVLGILLAYRII-- 704

  Fly   430 SSLERNQEALRRYL---YSLYAWGGPLLITFVAACVDQLPETTLLRPGFGQLYCW--FDNRNLSI 489
              |..:..||...:   :.| .:|.||||:.:...|.| |..:..|..    .||  :.:::..:
Mouse   705 --LVFHHMALTTMMAIGFCL-GYGCPLLISIITLAVTQ-PSNSYKRND----VCWLNWSDKSKPL 761

  Fly   490 FAYFYGPIGLLLCANIALFVSTTHQLTCGLWK-------RDDVKSSSEKSALGRVCLKLVVVMGV 547
            .| |..|...::..|:.:.:....:    ||:       ..|.|:::.:  :|:..|.|..::|:
Mouse   762 LA-FVVPALTIVAVNLVVVLLVLRK----LWRPAVGERLNQDDKATAIR--MGKSLLVLTPLLGL 819

  Fly   548 TWIADI--------LSWLVGGPHGVWFFTDLINALQGVFIF 580
            ||...|        |:|.|       .|. |:||.||.|||
Mouse   820 TWGFGIGTMANSHNLAWHV-------LFA-LLNAFQGFFIF 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	64/287 (22%)
Adgrf1	XP_006525183.1	SEA	172..258	CDD:366610
		GPS	549..590	CDD:197639	10/74 (14%)
		7tm_GPCRs	603..866	CDD:391938	67/278 (24%)
		TM helix 1	603..626	CDD:341315	4/23 (17%)
		TM helix 2	641..663	CDD:341315	4/21 (19%)
		TM helix 3	675..702	CDD:341315	8/28 (29%)
		TM helix 4	716..736	CDD:341315	6/20 (30%)
		TM helix 5	757..786	CDD:341315	4/33 (12%)
		TM helix 6	803..829	CDD:341315	7/27 (26%)
		TM helix 7	834..859	CDD:341315	12/27 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900