Protein Alignment mthl1 and VIPR1

DIOPT Version :10

• Sequence 1: NP_573140.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_004615.2
• Gene: VIPR1 / 7433
• HGNCID: 12694
• Length: 457
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 109/479 - (22%)
• Similarity: 162/479 - (33%)
• Gaps: 147/479 - (30%)

  Fly   247 GQPGGYSIAGDWQDAKLDRN---TAMLQLPHKNLSAGQYCLEHTQRE------------------ 290
            |..||       |.|:|...   ..|:::.||.      |||..|.|
Human    24 GPAGG-------QAARLQEECDYVQMIEVQHKQ------CLEEAQLENETIGCSKMWDNLTCWPA 75

  Fly   291 ---GEVKIIACQ---HLFSSAAGAGIHDGSIG---------------GTIEQANGQNLQKAVLTG 334
               |:|.::||.   .||||..|..:......               |..::|...:.|:.:..|
Human    76 TPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYG 140

  Fly   335 ----GILVSIVFLSATLVAGFLLPAVHHALHWRCQICYVTCLLFGKILLA-----IEEL------ 384
                |..:......|||:....:.::...||  |...|:...||...:|.     |::|
Human   141 SVKTGYTIGYGLSLATLLVATAILSLFRKLH--CTRNYIHMHLFISFILRAAAVFIKDLALFDSG 203

  Fly   385 -SSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYL--YSL 446
             |.....||..|....:..|:..:|.||||......::        :.|..:..:.|:|.  |.|
Human   204 ESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLY--------TLLAVSFFSERKYFWGYIL 260

  Fly   447 YAWGGPLLITFVAACVDQLPETTLLRPGFGQLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVST 511
            ..||.|...|.|         .|:.|..|....|| |..|.|::....|||...:..|..||:..
Human   261 IGWGVPSTFTMV---------WTIARIHFEDYGCW-DTINSSLWWIIKGPILTSILVNFILFICI 315

  Fly   512 THQLTCGLWKRDDVKS-SSEKSALGRVCLKLVVVMGVTWIADILSWLVGGPHGVWFFTD------ 569
            ...|...|...|..|| ||..|.|.|..|.|:.:.||.:|.            ..||.|
Human   316 IRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIM------------FAFFPDNFKPEV 368

  Fly   570 ------LINALQGVFIFIVVGC------QPQVWTACRRI-------FCPRLRHD----------- 604
                  ::.:.|| |:..::.|      |.::....||.       :.|:.||.
Human   369 KMVFELVVGSFQG-FVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCST 432

  Fly   605 ----ITNTTNGVQHSSSSQGLPSM 624
                :|..:.|.:.|||.|...|:
Human   433 QVSMLTRVSPGARRSSSFQAEVSL 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_573140.1	7tmB3_Methuselah-like	326..598	CDD:410632	74/315 (23%)
		TM helix 1	327..352	CDD:410632	6/28 (21%)
		TM helix 2	362..384	CDD:410632	6/26 (23%)
		TM helix 3	396..423	CDD:410632	6/26 (23%)
		TM helix 4	441..461	CDD:410632	8/21 (38%)
		TM helix 5	485..515	CDD:410632	8/29 (28%)
		TM helix 6	530..557	CDD:410632	8/26 (31%)
		TM helix 7	562..587	CDD:410632	7/42 (17%)
VIPR1	NP_004615.2	HormR	59..128	CDD:214468	10/68 (15%)
		7tm_GPCRs	139..405	CDD:475119	71/298 (24%)
		TM helix 1	142..166	CDD:410628	4/23 (17%)
		TM helix 2	175..196	CDD:410628	5/20 (25%)
		TM helix 3	216..238	CDD:410628	6/21 (29%)
		TM helix 4	257..273	CDD:410628	7/24 (29%)
		TM helix 5	291..313	CDD:410628	6/21 (29%)
		TM helix 6	340..362	CDD:410628	8/33 (24%)
		TM helix 7	367..392	CDD:410628	4/25 (16%)