DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and adgrg6

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001356058.1	Gene:	adgrg6 / 561970	ZFINID:	ZDB-GENE-041014-357	Length:	1208	Species:	Danio rerio

Alignment Length:	474	Identity:	105/474 - (22%)
Similarity:	176/474 - (37%)	Gaps:	126/474 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 KNLSAG---QYCLEHTQREGEVKIIACQHLFSSAAGAGIHDGSI------GGTIEQANGQNLQKA 330
            :|.|.|   ..|...:.......:..|.||        .|.|.:      ...|::.|.:
Zfish   766 QNYSGGWNSDGCKVGSDSNSNRTVCLCNHL--------THFGILMDVSRAAELIDEKNNR----- 817

  Fly   331 VLTG----GILVSIVFLSATLVAGFLLPAVHHALHWRCQICYVTCLLFGKILLAIEELSSSLQPG 391
            |||.    |..:|.:|.:|||:.......:......:..:...|.|||..::..::...:|.:.
Zfish   818 VLTFITYIGCGISAIFSAATLLTYIAFEKLRRDYPSKILMNLSTSLLFLNMVFLLDGWLASYEI- 881

  Fly   392 SAACHTLAITMQFFFLAAFFWLNTMCFNIW----WTFRDFRPSSLERNQEALRRYL--YSLYAWG 450
            ...|.|:|:.:.||.|.:|.|:.....:::    ..|..:           :|||:  :.:..||
Zfish   882 KELCVTVAVFLHFFLLTSFTWMGLESIHMYIALVKVFNTY-----------IRRYILKFCIVGWG 935

  Fly   451 GPLLITFVAACVDQLPETTLLRPGFGQLY-------------CWFDNR---NLSIFAYFYGPIGL 499
            .|..|..:...|.        :..:|:.|             ||..|.   .::..|||    .:
Zfish   936 VPAAIVGIVLAVS--------KDSYGKNYYGKGKDGQGTSEFCWILNPVVFYVTCVAYF----SI 988

  Fly   500 LLCANIALFVSTTHQLTCG-------LWKRDDVKSSSEKSALGRVCLKLVVVMGVTWIADILSWL 557
            :...|:|:|:....|: ||       ...|:|:..:.      |..:.|..::|:||.....:|
Zfish   989 IFLMNVAMFIVVMIQI-CGRNGKRSNRTLREDILRNL------RSVVSLTFLLGMTWGFAFFAW- 1045

  Fly   558 VGGPHGVWF---FTDLINALQGVFIFIVVGC------QPQVWTACRRIFCPRLR--------HDI 605
              ||..:.|   || :.|:|||:||| |..|      |.| |.  |.:.|.:||        ...
Zfish  1046 --GPVSLAFMYLFT-IFNSLQGLFIF-VFHCALKENVQKQ-WR--RYLCCGKLRLADNSDWSKTA 1103

  Fly   606 TNTTNGVQHSSSSQGLPSMAGGTEITQNTTTTTTTTNTTATHMPSNPAEDEVPEKAP-------- 662
            ||.|..|...:..:.|.|.:.|:.....|:....|.|..|.|  ||..:....:.:|
Zfish  1104 TNNTKKVSSDNLGKSLSSSSFGSTTANWTSKAKATLNPFARH--SNAGKSSSNQSSPKCSPSDGE 1166

  Fly   663 ----IAPVAPIV-KMETIC 676
                |.||..:: |::..|
Zfish  1167 PSSSILPVHQVLDKVKGYC 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	62/285 (22%)
adgrg6	NP_001356058.1	CUB	41..146	CDD:278839
		LamG	153..336	CDD:354964
		GPS	756..801	CDD:334696	9/42 (21%)
		7tmB2_GPR126	816..1086	CDD:320662	71/313 (23%)
		TM helix 1	818..843	CDD:320662	9/24 (38%)
		TM helix 2	853..875	CDD:320662	4/21 (19%)
		TM helix 3	886..913	CDD:320662	7/26 (27%)
		TM helix 4	928..944	CDD:320662	4/15 (27%)
		TM helix 5	975..998	CDD:320662	5/26 (19%)
		TM helix 6	1021..1046	CDD:320662	6/33 (18%)
		TM helix 7	1050..1075	CDD:320662	12/26 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810