Protein Alignment mthl1 and Adgrf2

DIOPT Version :9

• Sequence 1: NP_001285340.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: XP_017173054.1
• Gene: Adgrf2 / 435529
• MGIID: 2182728
• Length: 673
• Species: Mus musculus
• Alignment Length: 471
• Identity: 90/471 - (19%)
• Similarity: 149/471 - (31%)
• Gaps: 186/471 - (39%)

  Fly   264 DRNTA--MLQLPHKNLSAGQYCLEHTQREGEVKIIACQHLFSSAAGAGIHDGSIG---------- 316
            |||::  :||..| :.::..:..||        :|...|:|....|..:..||:|
Mouse   193 DRNSSCVLLQSIH-SFASKLFMKEH--------LINISHVFIHTLGTVVSRGSLGKNFTFSMRIN 248

  Fly   317 GTIEQANG------QNLQK----------AVLTGGILVSIVFLSATLVAGFLLPAV--------- 356
            .|.::..|      :.|||          |..|.|.::....|....|.|.:|..:
Mouse   249 ETSDKVTGRLLLSPEELQKVPSAFQVISIAFPTLGAILEASLLENVTVNGLVLSVILPEELKNIS 313

  Fly   357 ------------------HHALH----WR-CQ---------IC---------------------- 367
                              .|:|.    || |:         :|
Mouse   314 LIFEKIRKSGERKSQCVGWHSLESRWDWRACKTIQENSRQAVCRCRPNKLYTSFSILMSPNTLES 378

  Fly   368 ----YVT--------CLLFGKILLAIE---------------------ELSSSLQPGSA------ 393
                |:|        |.|.  |.||||                     .::::|....|
Mouse   379 PVLTYITYIGLGISICSLI--ICLAIEVLVWSQVTKTEISYLRHLCIANIAATLLMADAWFIVAS 441

  Fly   394 ----------ACHTLAITMQFFFLAAFFWLNT----MCFNIWWTFRDFRPSSLERNQEALRRYLY 444
                      .|......:.||:|:.|||:..    :.:.|...|.....|.|..:       |:
Mouse   442 FLSGPVLHHNGCVAATFFVHFFYLSVFFWMLAKALLILYGILIVFHTLPKSCLVAS-------LF 499

  Fly   445 SLYAWGGPLLITFVAACVDQLPETTLLRPGFGQL---YCWFDNRNLSIFAYFYGPIGLLLCAN-- 504
            |: .:|.||:|..:...|.:        ||.|.|   .||.:.........|..|...::..|
Mouse   500 SV-GYGCPLVIAIITLAVTE--------PGKGYLRPEACWLNWDMTKALLAFVVPALAIVVVNLI 555

  Fly   505 -IALFVSTTHQLTCGLWKRDDVKSSSEKSALGRVCLKLVV---VMGVTWIADILSWLVGGPHGVW 565
             :.:.:..|.:...|.....:|:      |:.|:|..:.:   ::|:||...|.:.:.|......
Mouse   556 TVTMVIIKTQRAAIGSSMFQEVR------AIVRICKNIAILTPLLGLTWGFGIATVINGHSLAFH 614

  Fly   566 FFTDLINALQGVFIFI 581
            ....|:|||||.||.:
Mouse   615 IIFSLLNALQGFFILL 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	69/384 (18%)
Adgrf2	XP_017173054.1	GPS	326..373	CDD:383024	6/46 (13%)
		7tmB2_GPR111_115	378..644	CDD:320660	57/277 (21%)
		TM helix 1	381..405	CDD:320660	9/25 (36%)
		TM helix 2	420..441	CDD:320660	2/20 (10%)
		TM helix 3	454..476	CDD:320660	6/21 (29%)
		TM helix 4	497..513	CDD:320660	6/23 (26%)
		TM helix 5	535..558	CDD:320660	3/22 (14%)
		TM helix 6	581..606	CDD:320660	6/24 (25%)
		TM helix 7	611..636	CDD:320660	8/20 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810