DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and mthl6

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	121/475 - (25%)
Similarity:	187/475 - (39%)	Gaps:	114/475 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LNDSQPINALEDPD-----YAANPLV--QQEPPKASLRLSKCCGKWGSYNTQLQNC--------D 213
            ||||.....|..|.     |....|.  .|||.|:.||...|         :|:.|        .
  Fly    39 LNDSYAYEELIIPAHLTGLYTFRQLADGSQEPVKSHLRACIC---------KLKPCIRFCCPRNK 94

  Fly   214 LQPNHQAAVDGLL----RLSP----QLPEGSYQTSYGLPD----------CGQPGGYSIAGDWQD 260
            :.||.:.: |||.    |::|    .|.:|:....|.|.|          |.:.  .|:..|  .
  Fly    95 MMPNSRCS-DGLTENLKRINPYLKITLEDGTIGKYYLLTDMIVLRYEFRYCEKV--VSVQED--Q 154

  Fly   261 AKLDRNTAMLQLPHKN--LSAGQYCLEHTQREGEVKIIACQHLFSSAAGAGIHDGSIGGTIEQAN 323
            .||..|.:.:..|..|  ||...||| |.:.|....|...:|::...:...:..   .|||.
  Fly   155 YKLYENGSFMIKPDVNWTLSKQWYCL-HPRLEDPNSIWILEHVYIPKSMPAVPQ---VGTIS--- 212

  Fly   324 GQNLQKAVLTGGILVSIVFLSATLVAGFLLPAVHHALHWRCQICYVTCLLFGKILLAIEELSSSL 388
                    :.|.||...|:|....:...|         .:|.||||.|.....::.|    ...|
  Fly   213 --------MVGCILTIAVYLYIKKLRNLL---------GKCFICYVFCKFVQYLIWA----GGDL 256

  Fly   389 QPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYLYSLYAWGGPL 453
            ...:..|.....|..||.||:.|||:.|...||...|     .:.|::.:....:|::|.||.|.
  Fly   257 NLWNNICSLAGYTNYFFALASHFWLSVMSHQIWKNLR-----LINRDERSYHFLIYNIYGWGTPA 316

  Fly   454 LITFVAACVD----QLPETTLLRPGFGQLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVSTTHQ 514
            ::|.:...||    ..|:.....||.|...||.:..:.|...|.|||:.:|...|:..|:.|.:.
  Fly   317 IMTAITYLVDWAWEDRPDKLNWIPGVGLYRCWINTYDWSAMIYLYGPMLILSLFNVVTFILTVNH 381

  Fly   515 LTCGLWKRDDVKSSSEKSALGRVC---------LKLVVVMGVTWIADILSWLVGGPHGVW----- 565
            :   :..:..||||:::.   |.|         |:|.|:||||.|::::::.| ..|..|
  Fly   382 I---MKIKSSVKSSTQQQ---RKCIQNNDFLLYLRLSVMMGVTGISEVITYFV-KRHKFWRQVLR 439

  Fly   566 ---FFTDLINALQGVFIFIV 582
               ||    :...|:.:|::
  Fly   440 VPNFF----HLGSGIVVFVL 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	71/270 (26%)
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	46/172 (27%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	56/221 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462213
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.750