Protein Alignment mthl1 and mthl2

DIOPT Version :10

• Sequence 1: NP_573140.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 365
• Identity: 101/365 - (27%)
• Similarity: 153/365 - (41%)
• Gaps: 63/365 - (17%)

  Fly   277 LSAGQYCLEH-TQREG---EVKIIACQHLFSSAAGAGIHDGSIGGTIEQANGQNLQKAVLTGGIL 337
            |...:|||:| |..||   .::||.             |:..|   :....||       |..::
  Fly   184 LDKSEYCLQHRTFGEGNNNSIRIIP-------------HNCLI---LPSRTGQ-------TVVMI 225

  Fly   338 VSIVFLSATLVAGFLLPAVHHALHWRCQICYVTCLLFGKILLAIE--ELSSSLQPGSAACHTLAI 400
            .|::.|..| :|.:|.......|..:|.|||:.||.||.:.|.::  |||...      |.....
  Fly   226 TSLICLVLT-IAVYLCVKKLMNLEGKCFICYMMCLFFGYLFLLLDLWELSLDF------CKAAGF 283

  Fly   401 TMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYLYSLYAWGGPLLITFVAACVDQL 465
            ...||.:||||||:.:..:.|....:...|...|::.|.  .|||.:||..||.:|.|....|.:
  Fly   284 LGYFFVMAAFFWLSIISRHYWKCLTNPCASMNIRSERAF--LLYSCFAWAMPLALTGVTYLADNV 346

  Fly   466 PETTLLRPGFG-QLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSSS 529
            ......:|..| :.:||...::.|...|||||:.||:..||.:||.|...:.       |.|.:.
  Fly   347 VNNEEWQPRVGDEGHCWIYTKSWSAMVYFYGPMVLLILFNITMFVLTAKHII-------DSKRTL 404

  Fly   530 EKSAL--GRV------------CLKLVVVMGVTWIADILSWLVGGPH---GVWFFTDLINALQGV 577
            .|.|.  ||:            .|.|..|||::|..:|.|:||....   .::...|..|..|||
  Fly   405 RKIARNEGRIQKLNSDKQNYTQFLLLFTVMGMSWSFEIFSYLVQREKLWVNIFLVADYFNWSQGV 469

  Fly   578 FIFIVVGCQPQVWTACRRIFCPRLRHDITNTTNGVQHSSS 617
            .||::...:.:.....::...|:.|....:.|.....|.|
  Fly   470 IIFVLFILRRKTLVLFKKQIFPKQRAFSRSATQSTIESIS 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_573140.1	7tmB3_Methuselah-like	326..598	CDD:410632	82/291 (28%)
		TM helix 1	327..352	CDD:410632	5/24 (21%)
		TM helix 2	362..384	CDD:410632	9/23 (39%)
		TM helix 3	396..423	CDD:410632	9/26 (35%)
		TM helix 4	441..461	CDD:410632	9/19 (47%)
		TM helix 5	485..515	CDD:410632	13/29 (45%)
		TM helix 6	530..557	CDD:410632	12/40 (30%)
		TM helix 7	562..587	CDD:410632	7/27 (26%)
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	11/39 (28%)
		7tmB3_Methuselah-like	215..489	CDD:410632	84/296 (28%)
		TM helix 1	215..240	CDD:410632	7/32 (22%)
		TM helix 2	249..269	CDD:410632	9/19 (47%)
		TM helix 3	279..306	CDD:410632	9/26 (35%)
		TM helix 4	322..342	CDD:410632	9/21 (43%)
		TM helix 5	367..397	CDD:410632	13/29 (45%)
		TM helix 6	419..446	CDD:410632	8/26 (31%)
		TM helix 7	454..479	CDD:410632	7/24 (29%)