DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and mthl3

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	123/538 - (22%)
Similarity:	218/538 - (40%)	Gaps:	130/538 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 LKFLPNTR---PTCRKDQTTEIFRSRGANVMLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLND 166
            |..|.|:.   |.|....|.:|     :....|.||: |:.|..|:  |:....:::..::. :|
  Fly    13 LLLLQNSNAEIPGCDFFDTVDI-----SKAPRFSNGS-YLYEGLLI--PAHLTAEYDYKLLA-DD 68

  Fly   167 SQPINALEDPDYAAN--PLVQQEPPK-ASLRLSKCCGKWGSYNTQLQNCDLQPNHQAAVDGLLRL 228
            |:...|......|.:  |.::...|: ..::.|||.|            |:..:.....|..:.:
  Fly    69 SKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYG------------DMSEDELNKHDPFVNV 121

  Fly   229 SPQLPEGS-----------YQTSYGLPDCGQ--------PGGYSIAGDWQDAKLDRNTAMLQLPH 274
            :  |.:||           .|:....|.|.:        ||        .:..|..|.::|:...
  Fly   122 T--LSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPG--------NEFTLFENGSLLRHWD 176

  Fly   275 K-NLSAGQYCLEHTQ-REGEVKI------IACQHLFSSAAGAGIHDGSIGGTIEQANGQNLQKAV 331
            | .||..:||::|.. ::..::|      ::.:|                           .:..
  Fly   177 KVELSKREYCVQHLSFKDDSIRIAPHFCPLSSEH---------------------------SRTW 214

  Fly   332 LTGGILVSIVFLSATLVAGFLLPAVHHALHWRCQICYVTCLLFGKILLAIEELSSSLQPGSAACH 396
            .|..|::|::.:..| ::.:|.......||.:|.|||:..|..|...|.:.....|    |..|.
  Fly   215 KTVAIVISLICIILT-ISVYLYVEKLRNLHGKCFICYLASLFLGYFFLVLNVWKYS----SGFCV 274

  Fly   397 TLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYL-------YSLYAWGGPLL 454
            |......|..:||||||:.:...:|        :|...|...|.|:|       |:|||||..||
  Fly   275 TAGFLGYFSVIAAFFWLSVISLTLW--------NSFSGNSSWLNRFLPQNRFLSYNLYAWGMALL 331

  Fly   455 ITFVAACVDQLPETTLLRP--GFGQLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVSTTHQLTC 517
            :|.:....||:.:...|||  |.|: .||....::::..|||||:.|::..||.:||.|..::.
  Fly   332 LTAITYIADQVVKNEKLRPRVGVGK-NCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIM- 394

  Fly   518 GLWKRDDVKSSSEKSALGR---------VCLKLVVVMGVTWIADILSWLVGGPHGVW----FFTD 569
             ..|::....:.::....|         :.|:|.::||::|..:|:|:|: ..:..|    ...|
  Fly   395 -KVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLL-SKNQAWAKAFMVAD 457

  Fly   570 LINALQGVFIFIVVGCQP 587
            ..|..||..||::...:|
  Fly   458 YFNWSQGTVIFLLFVLRP 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	75/271 (28%)
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	40/208 (19%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	67/235 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.820